Results 71 to 80 of about 107,687,715 (215)

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

Syndecan-1: a dynamic regulator of the myeloma microenvironment [PDF]

Clinical & Experimental Metastasis, 2007
Emerging data in myeloma and other cancers indicates that heparan sulfate proteoglycans promote tumor progression by enhancing their growth and metastasis. By acting as key regulators of cell signaling via their interactions with multiple growth and angiogenic factors, heparan sulfates mediate a shift in the microenvironment that supports the tumor as ...
Ralph D, Sanderson, Yang, Yang
openaire   +2 more sources

Syndecan-1 and Syndecan-4 Are Independent Indicators in Breast Carcinoma

, 2011
Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because this four-member family of transmembrane receptors regulates cell adhesion, proliferation, and differentiation.
Maria E. Lendorf, Pauliina Kronqvist, Manon-Jensen, Tina, Tina Manon-Jensen, Lendorf, Maria E, Couchman, John R, Hinke A. B. Multhaupt, Kronqvist, Pauliina, Multhaupt, Hinke A B, John R. Couchman   +9 more
core   +1 more source

Physiological and anatomical aspects of the reproduction of mice with reduced Syndecan-1 expression

Reproductive Biology and Endocrinology, 2019
Background Syndecan-1 is a heparan sulfate proteoglycan acting as a co-receptor for cytokines and growth factors mediating developmental, immunological and angiogenic processes.
Christina Gougoula, Alexandra P. Bielfeld, Sarah J. Pour, Jan-S. Krüssel, Martin Götte, W. Peter M. Benten, Dunja M. Baston-Büst   +6 more
doaj   +1 more source

Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells

Mediators of Inflammation, 2017
Successful implantation of the embryo into the human receptive endometrium is substantial for the establishment of a healthy pregnancy. This study focusses on the role of Syndecan-1 at the embryo-maternal interface, the multitasking coreceptor ...
Dunja Maria Baston-Buest, Olga Altergot-Ahmad, Sarah Jean Pour, Jan-Steffen Krüssel, Udo Rudolf Markert, Tanja Natascha Fehm, Alexandra Petra Bielfeld   +6 more
doaj   +1 more source

Application of Force to a Syndecan-4 Containing Complex With Thy-1–αVβ3 Integrin Accelerates Neurite Retraction

Frontiers in Molecular Biosciences, 2020
Inflammation contributes to the genesis and progression of chronic diseases, such as cancer and neurodegeneration. Upregulation of integrins in astrocytes during inflammation induces neurite retraction by binding to the neuronal protein Thy-1, also known
Francesca Burgos-Bravo, Francesca Burgos-Bravo, Francesca Burgos-Bravo, Samuel Martínez-Meza, Samuel Martínez-Meza, Andrew F. G. Quest, Andrew F. G. Quest, Christian A. M. Wilson, Lisette Leyton, Lisette Leyton   +9 more
doaj   +1 more source

Syndecan-2 cytoplasmic domain regulates colon cancer cell migration via interaction with syntenin-1

, 2019
The cell surface heparan sulfate proteoglycan, syndecan-2, is crucial for the tumorigenic activity of colon cancer cells. However, the role played by the cytoplasmic domain of the protein remains unclear. Using colon cancer cells transfected with various
오억수
core   +1 more source

High molecular weight sodium hyaluronate improves survival of syndecan-1-deficient septic mice by inhibiting neutrophil migration.

PLoS ONE, 2021
MethodsSepsis was induced by cotton smoke inhalation followed by intranasal administration of Pseudomonas aeruginosa in female (> 6 months) Balb/c and syndecan-1 knockout mice. Survival of mice, lung capillary endothelial glycocalyx integrity, lung water
Tuvshintugs Baljinnyam, Enkhtuya Radnaa, Casey M Ouellette, Christina Nelson, Yosuke Niimi, Clark R Andersen, Vsevolod Popov, Jae-Woo Lee, Donald S Prough, Perenlei Enkhbaatar   +9 more
doaj   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

R-spondin(g) to syndecan-1 in myeloma [PDF]

Blood, 2018
In this issue of Blood , Ren et al investigate mechanisms underlying a novel strategy to block multiple myeloma (MM) cell proliferation by targeting the heparin sulfate (HS) proteoglycan syndecan-1 and identify the Wnt/β-catenin pathway as a critical mediator of this approach. If validated, these findings could lead to new therapeutic strategies in MM
openaire   +2 more sources