Results 61 to 70 of about 107,687,715 (215)

Elevated plasma syndecan-1 as glycocalyx injury marker predicts unfavorable outcomes after rt-PA intravenous thrombolysis in acute ischemic stroke

Frontiers in Pharmacology, 2022
Purpose: We aimed to examine the prognostic value of syndecan-1 as a marker of glycocalyx injury in patients with acute ischemic stroke (AIS) receiving rt-PA intravenous thrombolysis.Methods: The study included 108 patients with AIS treated with rt-PA ...
Fangfang Zhao, Rongliang Wang, Rongliang Wang, Yuyou Huang, Yuyou Huang, Lingzhi Li, Lingzhi Li, Liyuan Zhong, Liyuan Zhong, Yue Hu, Yue Hu, Ziping Han, Ziping Han, Junfen Fan, Junfen Fan, Ping Liu, Yangmin Zheng, Yangmin Zheng, Yumin Luo, Yumin Luo, Yumin Luo   +20 more
doaj   +1 more source

Differential expression and distribution of syndecan-1 and -2 in periodontal wound healing of the rat

, 2002
The definitive version is available at www.blackwell-synergy.comCell-surface proteoglycans participate in several biological functions including interactions with adhesion molecules, growth factors and a variety of other effector molecules.
Worapamorn, W., Bartold, P. Mark, Xiao, Y., Li, Huika, Young, William G, Young, WG, Li, H, Xiao, Yin, Worapamorn, W, Bartold, PM, Young, W., Bartold, P., Li, H., Xiao, Y   +13 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Syndecan-1 [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2009
Objective— Arterial injury induces smooth muscle cell (SMC) proliferation, migration, and intimal accumulation of cells and extracellular matrix. These processes are regulated by the administration of the glycosaminoglycans heparin and heparan sulfate, but little is known about the role of endogenous
Nozomi, Fukai, Richard D, Kenagy, Lihua, Chen, Lu, Gao, Guenter, Daum, Alexander W, Clowes   +5 more
openaire   +2 more sources

Specific syndecan-1 domains regulate mesenchymal tumor cell adhesion, motility and migration. [PDF]

PLoS ONE, 2011
BackgroundSyndecans are proteoglycans whose core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan chains. Syndecans are involved in many important cellular processes.
Fang Zong, Eleni Fthenou, Filip Mundt, Tünde Szatmári, Ilona Kovalszky, László Szilák, David Brodin, George Tzanakakis, Anders Hjerpe, Katalin Dobra   +9 more
doaj   +1 more source

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

Cleavage of Syndecan-1 Promotes the Proliferation of the Basal-Like Breast Cancer Cell Line BT-549 Via Akt SUMOylation

Frontiers in Cell and Developmental Biology, 2021
Basal-like breast cancer is characterized by an aggressive clinical outcome and presence of metastasis, for which effective therapies are unavailable.
Satomi Nadanaka, Yaqiang Bai, Hiroshi Kitagawa   +2 more
doaj   +1 more source

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

The endothelial glycocalyx in syndecan-1 deficient mice [PDF]

Microvascular Research, 2013
The existence of a hydrodynamically relevant endothelial glycocalyx has been established in capillaries, venules, and arterioles in vivo. The glycocalyx is thought to consist primarily of membrane-bound proteoglycans with glycosaminoglycan side-chains, membrane-bound glypicans, and adsorbed plasma proteins.
Michele D, Savery, John X, Jiang, Pyong Woo, Park, Edward R, Damiano   +3 more
openaire   +2 more sources

Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection [PDF]

, 2010
Herpes simplex virus type 1 (HSV-1) is an important human pathogen and a leading cause of infectious blindness in the developed world. HSV-1 exploits heparan sulfate proteoglycans (HSPG) for attachment to cells. While the significance of heparan sulphate
T. Valyi-Nagy, J. Liu, Valyi-Nagy, Tibor, S. Bacsa, Liu, Jian, S. Dosa, Karasneh, Ghadah, Dosa, Sandor, G. Karasneh, D. Shukla, Bacsa, Sarolta, Shukla, Deepak   +11 more
core   +1 more source