Results 51 to 60 of about 107,687,715 (215)
BMC Infectious Diseases, 2023 Background With the emergence of coronavirus disease of 2019 (COVID-19), several blood biomarkers have been identified, including the endothelial biomarker syndecan-1, a surface proteoglycan.
Elina Ghondaghsaz +5 more
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Syndecan-1 as a severity biomarker for patients with trauma
Frontiers in Medicine, 2022 Tissue injury and hemorrhage induced by trauma lead to degradation of the endothelial glycocalyx, causing syndecan-1 (SDC-1) to be shed into the blood. In this study, we investigated whether serum SDC-1 is useful for evaluating trauma severity in patients.
Keiko Suzuki +26 more
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Antirheumatic treatment is associated with reduced serum Syndecan-1 in Rheumatoid Arthritis.
PLoS ONE, 2021 The endothelial glycocalyx (EG) is essential for proper function of the endothelium and for vascular integrity, but its role in premature atherogenesis in rheumatoid arthritis (RA) has not been studied yet.
Gia Deyab +10 more
doaj +1 more source
PLoS ONE, 2009 BackgroundLung injury promotes the expression of matrix metalloproteinase-7 (MMP7, matrilysin), which is required for neutrophil recruitment and re-epithelialization. MMP7 governs the lung inflammatory response through the shedding of syndecan-1. Because
Peter Chen +5 more
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Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells
Cell Communication and Signaling, 2020 Background Syndecans regulate cell migration thus having key roles in scarring and wound healing processes. Our previous results have shown that Thy-1/CD90 can engage both αvβ3 integrin and Syndecan-4 expressed on the surface of astrocytes to induce cell
Alejandra Valdivia +11 more
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Syndecan-1 in the Mouse Parietal Peritoneum Microcirculation in Inflammation
, 2016 To examine whether syndecan-1 co-localizes with chemokines in vivo, Alexa Fluor 568-labeled anti-syndecan-1 and Alexa Fluor 488-labeled anti-mouse macrophage inflammatory protein-2 (MIP-2; CXCL2) monoclonal rat antibody (40 µg, clone 40605; R&D Systems ...
Paulina M. Kowalewska1 Amanda L. Patrick,2 and Alison E. Fox-Robichaud2,* (2851181)
core +1 more source
PLoS ONE, 2021 Syndecan-1 is found in the endothelial glycocalyx and is released into the bloodstream during stressed conditions, including severe diseases such as acute kidney injury, chronic kidney disease, and cardiovascular disease.
Yuichiro Kitagawa +29 more
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Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1
Biomolecules, 2020 Syndecan-1 is a transmembrane heparan sulfate proteoglycan which is indispensable in the structural and functional integrity of epithelia. Normal hepatocytes display strong cell surface expression of syndecan-1; however, upon malignant transformation ...
Péter Hollósi +10 more
doaj +1 more source
Functional Characterization of Mouse Syndecan-1 Promoter [PDF]
Journal of Biological Chemistry, 1996 The members of the syndecan family are temporally and spatially expressed heparan sulfate proteoglycans of various tissues, where they mediate extracellular influences on cell morphology and behavior. Functional characterization of the mouse syndecan-1 promoter was carried out in order to elucidate the mechanisms involved in the maintenance of the high
T, Vihinen +4 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source