Results 121 to 130 of about 24,713 (214)

R-spondin(g) to syndecan-1 in myeloma [PDF]

Blood, 2018
In this issue of Blood , Ren et al investigate mechanisms underlying a novel strategy to block multiple myeloma (MM) cell proliferation by targeting the heparin sulfate (HS) proteoglycan syndecan-1 and identify the Wnt/β-catenin pathway as a critical mediator of this approach. If validated, these findings could lead to new therapeutic strategies in MM
openaire   +2 more sources

Remote Pancreatic Response to Severe Polytrauma Correlates With Clinical Outcome

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Acute pancreatic injury can result from blunt or sharp force trauma, often leading to serious complications. While direct pancreatic trauma is associated with high rates of infection, organ failure, and mortality, little is known about the pancreas as a potential secondary target and remote trauma organ and thereby as a booster of ...
Rebecca Halbgebauer, Lisa Wohlgemuth, Jonas Wrba, Sonja Braumüller, Enes Kumral, Ludmila Lupu, Clara Morgenstern, Lucas Bettac, Sebastian Wiese, Benjamin Mayer, Paolo Cinelli, Daniel Rittirsch, Hans‐Christoph Pape, Francesco Roselli, Thomas Seufferlein, Alexander Kleger, Markus Breunig, Markus Huber‐Lang   +17 more
wiley   +1 more source

Is Endothelial Nitric Oxide Synthase a Moonlighting Protein Whose Day Job is Cholesterol Sulfate Synthesis? Implications for Cholesterol Transport, Diabetes and Cardiovascular Disease [PDF]

, 2012
Theoretical inferences, based on biophysical, biochemical, and biosemiotic considerations, are related here to the pathogenesis of cardiovascular disease, diabetes, and other degenerative conditions.
Ali, Ann Lauritzen, Billecke, Brune, Cignarelli, Cordelier, Deniziak, Dimmeler, Drayer, Gajkowska, Girard, Gross, Hao, Hart, Ho, Hopwood, Hopwood, Ignarro, Jagger, Jakubowski, Joensuu, Laurie Lentz-Marino, McCully, Nakae, Pfennig, Pollack, Randriamboavonjy, Rearick, Robert Davidson, Seidel, Stephanie Seneff, Suzuki, Tedder, Teske, Tsai, Voeikov   +35 more
core   +4 more sources

Identification of SDC1 as a Key Regulator and Therapeutic Target in Rheumatoid Arthritis via JAK2‐STAT3 Pathway

International Journal of Rheumatic Diseases, Volume 29, Issue 2, February 2026.
ABSTRACT Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disorder with unclear molecular mechanisms, complicating early diagnosis and treatment. This study aimed to identify hub genes and pathways driving RA pathogenesis and assess their therapeutic potential.
Gan Cao, Zhihui Wu, Yatao Du, Dongxue Dai, Yang Sun, Xi Jia, Huixin Cai   +6 more
wiley   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Research Progress of Exosome‐Derived microRNA in Alcohol Use Disorders: A Critical Review

Addiction Biology, Volume 31, Issue 2, February 2026.
Exosome‐derived microRNAs represent stable and mechanistically active mediators of alcohol‐induced multi‐organ injury. This review summarizes how chronic alcohol exposure reshapes exosomal miRNA cargo across the liver, immune system, and brain, highlighting key miRNAs with diagnostic value and therapeutic potential.
Bo Zhang, Ting ting Xie, Qiang Ma, Ya ping Jiang, Yu mei Wang   +4 more
wiley   +1 more source

A tumorsejtek szabályozási zavarai - a diagnosis és a terápia alapja = Disturbances in cancer cell regulation - a basis to design diagnosis and therapy [PDF]

, 2009
A project a daganatok viselkedését befolyásoló olyan molekuláris történésekkel foglalkozott, amelyek felhasználhatók diagnosztikai markerként vagy terápiás célpontként. Ennek eredményeként mutattuk ki NSCLC-ben az EGFR mutációk jellegét és gyakoriságát,
Kopper, László, Kovalszky, Ilona, Matolcsy, András, Nagy, Péter, Paku, Sándor, Peták, István, Sebestyén, Anna   +6 more
core  

Syndecan-1 Regulates Vascular Smooth Muscle Cell Phenotype

PLoS ONE, 2014
We examined the role of syndecan-1 in modulating the phenotype of vascular smooth muscle cells in the context of endogenous inflammatory factors and altered microenvironments that occur in disease or injury-induced vascular remodeling.Vascular smooth muscle cells (vSMCs) display a continuum of phenotypes that can be altered during vascular remodeling ...
Chaterji, Somali, Lam, Christoffer H., Ho, Derek S., Proske, Daniel C., Baker, Aaron B.   +4 more
openaire   +5 more sources

CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression

The FEBS Journal, Volume 293, Issue 3, Page 709-728, February 2026.
CLEC18A is a previously poorly characterized C‐type lectin. We mapped the expression of CLEC18A to the proximal tubule of the kidney and found CLEC18A to interact with sulfated glycosaminoglycans on proteoglycans. Furthermore, we found that CLEC18A plays an important role in hindering the progression of clear cell renal cell carcinomas in humans and in
Gustav Jonsson, Maura Hofmann, Stefan Mereiter, Lauren Hartley‐Tassell, Masahiro Onji, Irma Sakic, Tiago Oliveira, David Hoffmann, Maria Novatchkova, Alexander Schleiffer, Josef M. Penninger   +10 more
wiley   +1 more source

Bacterial porphyrins in healthy skin: Microbiota components impact melanogenesis and age‐related processes leading to Porphyr'ageing

International Journal of Cosmetic Science, Volume 48, Issue 1, Page 186-199, February 2026.
Porphyrins, previously linked only to acne inflammation, are now implicated in skin ageing. Their presence correlates with increased melanin, inflammation, and oxidative stress, contributing to premature ageing signs. This study introduces the concept of “Porphyr'ageing,” highlighting the detrimental effects of bacterial metabolites on skin health and ...
Marie Meunier, Morgane De Tollenaere, Cyrille Jarrin, Emilie Chapuis, Marine Bracq, Laura Lapierre, Catherine Zanchetta, Jean Tiguemounine, Amandine Scandolera, Romain Reynaud   +9 more
wiley   +1 more source