Results 11 to 20 of about 23,981 (219)
Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis [PDF]
PLOS ONE, 2012 Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various ...
Adriana T. Larregina +7 more
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Syndecan-1 (CD138), Carcinomas and EMT [PDF]
International Journal of Molecular Sciences, 2021 Cell surface proteoglycans are known to be important regulators of many aspects of cell behavior. The principal family of transmembrane proteoglycans is the syndecans, of which there are four in mammals. Syndecan-1 is mostly restricted to epithelia, and bears heparan sulfate chains that are capable of interacting with a large array of polypeptides ...
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on SDC1 (syndecan 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Purushothaman, A, Sanderson, RD
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Syndecan-1 (CD138) modulates triple-negative breast cancer stem cell properties via regulation of LRP-6 and IL-6-mediated STAT3 signaling. [PDF]
PLoS ONE, 2013 Syndecan-1 (CD138), a heparan sulfate proteoglycan, acts as a coreceptor for growth factors and chemokines and is a molecular marker associated with epithelial-mesenchymal transition during development and carcinogenesis.
Sherif A Ibrahim +12 more
doaj +1 more source
Focus on Molecules: Syndecan-1 [PDF]
Experimental Eye Research, 2011 Syndecan-1 (NP_001006947.1) is a widely expressed cell surface heparan sulfate proteoglycan whose molecular cloning as ‘syndecan’ (Saunders et al, ’89), later known as syndecan-1, was the springboard for the discovery of syndecans-2 through -4. Expression in the eye has been documented in corneal, limbal (GDS2433) and conjunctival epithelial cells ...
Yinghui, Zhang +4 more
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Syndecan-1 in Liver Diseases [PDF]
Pathology & Oncology Research, 2019 Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on the surfaces of hepatocytes and cholangiocytes. Due to liver diseases the amount of syndecan-1 increases in the liver.
Eszter Regős +6 more
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Scientific Reports, 2020 The heparan sulfate proteoglycan Syndecan-1, a mediator of signals between the extracellular matrix and cells involved is able to interact with OPG, one of the major regulators of osteoclastogenesis.
Melanie Timmen +5 more
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Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies
Scientific Reports, 2021 Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction.
H. Hassani Lahsinoui +9 more
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Hypertension, 2010 Cardiac fibrosis is characterized by net accumulation of extracellular matrix in the myocardium and is an integral component of most cardiac pathological conditions. Fibrotic remodeling of the ventricle has profound consequences on cardiac function. Increased deposition of interstitial collagen in the perimysial space is initially associated with a ...
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Inhibition by the Soluble Syndecan-1 Ectodomains Delays Wound Repair in Mice Overexpressing Syndecan-1 [PDF]
Journal of Biological Chemistry, 2004 Wound repair is a tightly regulated process stimulated by proteases, growth factors, and chemokines, which are modulated by heparan sulfate. To characterize further the role of the heparan sulfate proteoglycan syndecan-1 in wound repair, we generated mice overexpressing syndecan-1 (Snd/Snd) and studied dermal wound repair.
Varpu, Elenius +4 more
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