Results 11 to 20 of about 11,302 (215)
Syndecan-1 as a Mediator of Bacteria-Enterocyte Interactions [PDF]
The Scientific World JOURNAL, 2006 Michelle J. Henry-Stanley +1 more
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Syndecan-1 (CD138), Carcinomas and EMT [PDF]
International Journal of Molecular Sciences, 2021 Cell surface proteoglycans are known to be important regulators of many aspects of cell behavior. The principal family of transmembrane proteoglycans is the syndecans, of which there are four in mammals. Syndecan-1 is mostly restricted to epithelia, and bears heparan sulfate chains that are capable of interacting with a large array of polypeptides ...
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Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells. [PDF]
PLoS ONE, 2009 Syndecan-1 forms complexes with growth factors and their cognate receptors in the cell membrane. We have previously reported a tubulin-mediated translocation of syndecan-1 to the nucleus.
Fang Zong +9 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on SDC1 (syndecan 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Purushothaman, A, Sanderson, RD
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Syndecan-1 (CD138) modulates triple-negative breast cancer stem cell properties via regulation of LRP-6 and IL-6-mediated STAT3 signaling. [PDF]
PLoS ONE, 2013 Syndecan-1 (CD138), a heparan sulfate proteoglycan, acts as a coreceptor for growth factors and chemokines and is a molecular marker associated with epithelial-mesenchymal transition during development and carcinogenesis.
Sherif A Ibrahim +12 more
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The expression of syndecan-1 in psoriatic epidermis [PDF]
Archives of Dermatological Research, 2008 Psoriasis is a chronic inflammatory skin disease characterized by exaggerated keratinocyte proliferation. Current opinion indicates that psoriasis is driven by T cell-mediated immune responses targeting keratinocytes. However, psoriasis cannot be explained solely on the basis of T-cell activation, and it is likely that an intrinsic alteration in ...
Tomas, Davor +3 more
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Syndecan-1 as a Regulator of Chemokine Function [PDF]
The Scientific World JOURNAL, 2003 Chemokines are a family of chemotactic cytokines that play critical roles in leukocyte recruitment to sites of inflammation. Characterized by the presence of conserved aminoterminal cysteine residues, these lowmolecular weight proteins signal through G-protein–coupled receptors with seven transmembrane domains[1,2].
Martin Götte, Frank Echtermeyer
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Molecular functions of syndecan-1 in disease [PDF]
Matrix Biology, 2012 Syndecan-1 is a cell surface heparan sulfate proteoglycan that binds to many mediators of disease pathogenesis. Through these molecular interactions, syndecan-1 can modulate leukocyte recruitment, cancer cell proliferation and invasion, angiogenesis, microbial attachment and entry, host defense mechanisms, and matrix remodeling.
Pyong Woo Park +2 more
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Scientific Reports, 2020 The heparan sulfate proteoglycan Syndecan-1, a mediator of signals between the extracellular matrix and cells involved is able to interact with OPG, one of the major regulators of osteoclastogenesis.
Melanie Timmen +5 more
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Novel genes and pathways modulated by syndecan-1: implications for the proliferation and cell-cycle regulation of malignant mesothelioma cells. [PDF]
PLoS ONE, 2012 Malignant pleural mesothelioma is a highly malignant tumor, originating from mesothelial cells of the serous cavities. In mesothelioma the expression of syndecan-1 correlates to epithelioid morphology and inhibition of growth and migration.
Tünde Szatmári +7 more
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