Results 11 to 20 of about 24,713 (214)

Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis [PDF]

PLOS ONE, 2012
Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various ...
Adriana T. Larregina, Carol A. Feghali-Bostwick, Joseph M. Pilewski, Logan R. Mlakar, Sebastien Fuchs, Ximena D. Ruiz, Yukie Yamaguchi, Yunyun Su   +7 more
core   +13 more sources

Serum syndecan-1 is related to severity and prognosis of COVID-19 patients: a perspective cohort study [PDF]

BMC Pulmonary Medicine
Introduction Syndecan-1 is one of cell surface proteoglycans that mediates the connection between cytoskeleton and interstitial matrix. The previous studies have demonstrated that syndecan-1 exerts an essential role in several pulmonary diseases. However,
Mengmeng Ma, Qingqing Zhang, Yongxia Guo, Shushu Li, Ziyong Chen, Kui Liu, Lifang Cao, Meiling Xie, Yingli Wang, Yalin Jiang, Lin Fu   +10 more
doaj   +2 more sources

Serum Syndecan-1 is Associated With Kidney and Cardiovascular Outcomes in Idiopathic Nephrotic Syndrome [PDF]

Kidney International Reports
Introduction: Idiopathic nephrotic syndrome (INS) is associated with important kidney and cardiovascular morbidities. We tested the hypothesis that serum syndecan-1, a marker of endothelial glycocalyx injury, can help identify patients at risk for ...
Colin Bauer, Arshia Anand, Christine Sethna, Jonathan Troost, Tarak Srivastava, Imtiazul Islam, Audrey Fetsko, Julie A. Dougherty, William E. Smoyer, Richard J. Johnson, Gabriel Cara-Fuentes   +10 more
doaj   +2 more sources

Aqueous humor levels of syndecan-1 and syndecan-4 associated with OCTA metrics in diabetic retinopathy [PDF]

Frontiers in Medicine
PurposeAttenuated endothelium glycocalyx had been shown to be related to vascular damage during diabetic retinopathy (DR). Syndecans were pivotal components of retinal glycocalyx, which could be released from the endothelial surface by a highly regulated
Jixian Ma, Yue Bian, Yazhou Qin, Yingni Huang, Yuyao Qu, Li Qin, Anming Xie, Qiuping Liu, Xiayu Xu, Jianqin Lei, Jingming Li   +10 more
doaj   +2 more sources

Serum expression of ESM-1 and Syndecan-1 and its relationship with disease severity in children with Mycoplasma pneumoniae pneumonia [PDF]

Italian Journal of Pediatrics
Background This study aim to investigate the role of endothelial damage in the pathogenesis of Mycoplasma pneumoniae pneumonia (MPP) by comparing serum levels of endothelial cell-specific molecule 1 (ESM-1) and Syndecan-1 in patients with varying degrees
Yanjuan Yu, Yanyan Su, Xiuhong Jin, Xiangfeng Zhang, Yeran Yang, Yuelin Shen   +5 more
doaj   +2 more sources

A novel role for syndecan-3 in angiogenesis [v1; ref status: indexed, http://f1000r.es/2g6] [PDF]

F1000Research, 2013
Syndecan-3 is one of the four members of the syndecan family of heparan sulphate proteoglycans and has been shown to interact with numerous growth factors via its heparan sulphate chains.
Giulia De Rossi, James R. Whiteford
doaj   +5 more sources

Syndecan-1 and E-Cadherin Expression in Canine Cutaneous Squamous Cell Carcinoma [PDF]

Veterinary Sciences
Cutaneous squamous cell carcinoma (CSCC) in dogs is a locally invasive tumor that typically occurs in areas of poorly pigmented skin due to sun exposure.
Rita Files, Cláudia Cardoso, Justina Prada, Filipe Silva, Isabel Pires   +4 more
doaj   +2 more sources

Syndecan-1 downregulates syndecan-4 expression by suppressing the ERK1/2 and p38 MAPK signaling pathways in cultured vascular endothelial cells

Biochemistry and Biophysics Reports, 2021
Syndecan-1 and syndecan-4 are members of the syndecan family of transmembrane heparan sulfate proteoglycans. Vascular endothelial cells synthesize both species of proteoglycans and use them to regulate the blood coagulation-fibrinolytic system and their ...
Takato Hara, Arisa Sato, Chika Yamamoto, Toshiyuki Kaji   +3 more
doaj   +1 more source

Syndecan-1 enhances proliferation, migration and metastasis of HT-1080 cells in cooperation with syndecan-2. [PDF]

PLoS ONE, 2012
Syndecans are transmembrane heparan sulphate proteoglycans. Their role in the development of the malignant phenotype is ambiguous and depends upon the particular type of cancer.
Bálint Péterfia, Tibor Füle, Kornélia Baghy, Krisztina Szabadkai, Alexandra Fullár, Katalin Dobos, Fang Zong, Katalin Dobra, Péter Hollósi, András Jeney, Sándor Paku, Ilona Kovalszky   +11 more
doaj   +1 more source

Circulating Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive Care

Frontiers in Cardiovascular Medicine, 2021
Background: Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host responses to infection. Recent studies have suggested that endotheliopathy may be the common basis for multiple organ failure in sepsis.
Kosaku Hatanaka, Takashi Ito, Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana   +7 more
doaj   +1 more source