Results 1 to 10 of about 74,456 (251)
Glucocorticoids and “Stress” Are Not Synonymous [PDF]
Integrative Organismal Biology, 2019 SynopsisReference to glucocorticoids as “stress hormones” has been growing in prevalence in the literature, including in comparative and environmental endocrinology. Although glucocorticoids are elevated in response to a variety of stressors in vertebrate animals, the primary functions of glucocorticoids are not responding to stressors and they are ...
S A MacDougall-Shackleton +3 more
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Genome Biology and Evolution, 2021 Synonymous mutations are often assumed to be neutral with respect to fitness because they do not alter the encoded amino acid and so cannot be “seen” by natural selection. Yet a growing body of evidence suggests that synonymous mutations can have fitness
Stephanie Bedhomme +2 more
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In silico methods for predicting functional synonymous variants
Genome Biology, 2023 Single nucleotide variants (SNVs) contribute to human genomic diversity. Synonymous SNVs are previously considered to be “silent,” but mounting evidence has revealed that these variants can cause RNA and protein changes and are implicated in over 85 ...
Brian C. Lin +4 more
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BMC Cancer, 2021 Background Synonymous mutations do not change the protein sequences. Automatically, they have been regarded as neutral events and are ignored in the mutation-based cancer studies.
Qun Li +5 more
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Are synonymous codons indeed synonymous?
Biomolecular Concepts, 2012 It has long been known that the distribution and frequency of occurence of synonymous codons can vary greatly among different species, and that the abundance of isoaccepting tRNA species could also be very different.
Venetianer Pál
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Synonymous codon usage regulates translation initiation
Cell Reports, 2023 Summary: Nonoptimal synonymous codons repress gene expression, but the underlying mechanisms are poorly understood. We and others have previously shown that nonoptimal codons slow translation elongation speeds and thereby trigger messenger RNA (mRNA ...
Chloe L. Barrington +7 more
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Somatic synonymous mutations in regulatory elements contribute to the genetic aetiology of melanoma
BMC Medical Genomics, 2020 Background Non-synonymous mutations altering tumor suppressor genes and oncogenes are widely studied. However, synonymous mutations, which do not alter the protein sequence, are rarely investigated in melanoma genome studies. Methods We explored the role
Di Zhang, Junfeng Xia
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Molecular Mechanisms and the Significance of Synonymous Mutations
BiomoleculesSynonymous mutations result from the degeneracy of the genetic code. Most amino acids are encoded by two or more codons, and mutations that change a codon to another synonymous codon do not change the amino acid in the gene product.
Peter Oelschlaeger
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The distribution of fitness effects among synonymous mutations in a gene under directional selection
eLife, 2019 The fitness effects of synonymous mutations, nucleotide changes that do not alter the encoded amino acid, have often been assumed to be neutral, but a growing body of evidence suggests otherwise.
Eleonore Lebeuf-Taylor +4 more
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A pan-cancer analysis of synonymous mutations
Nature Communications, 2019 Synonymous mutations do not alter amino acid sequence but may exert oncogenic effects in other ways. Here, the authors present a catalogue of synonymous mutations in cancer and characterise their properties.
Yogita Sharma +7 more
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