Results 11 to 20 of about 74,456 (251)
Synonymous Codons: Choose Wisely for Expression
Trends in Genetics, 2017 The genetic code, which defines the amino acid sequence of a protein, also contains information that influences the rate and efficiency of translation. Neither the mechanisms nor functions of codon-mediated regulation were understood.
Elizabeth Grayhack
exaly +2 more sources
Widespread position-specific conservation of synonymous rare codons within coding sequences. [PDF]
PLoS Computational Biology, 2017 Synonymous rare codons are considered to be sub-optimal for gene expression because they are translated more slowly than common codons. Yet surprisingly, many protein coding sequences include large clusters of synonymous rare codons. Rare codons at the 5'
Julie L Chaney +8 more
doaj +2 more sources
Linguistic Challenges of Translating the Holy Qurʼān into English A comparative Analysis [PDF]
Maǧallaẗ Kulliyyaẗ Al-Adāb - Ǧāmiʿaẗ Al-Fayūm, 2021 The Holy Qurʼān is the highest authority in Islam. It is the paramount source of the divine laws of the Islamic religion because the Qurʼān is the word from Allah intended for all times and all places.
fakhry عليبة
doaj +1 more source
ترادف صيغتي فَعَلَ و أَفْعَل في لغات العرب دراسة في التبيان في تفسير القرآن للطوسي
Maǧallaẗ Kulliyyaẗ Al-ādāb Ǧāmiʿaẗ Būrsaʿīd, 2023 قدَّم اللغويون القدماء لنا مجهودات عظيمة في الدرس اللغويّ، لكن كانت عنايتهم باللغات العربية قليلة،و فذُكرت بكثرة في بعض الكتب،و ذُكرت بقلَّة في كتب أخرى، وأغلب ما ذُكر هي لهجة قريش؛ لأنَّها اللغة الفصحى، ويهدف البحث إلى دراسة الترادف في صيغتي (فَعَلَ،و أَ
أميرة محمد محمد أمين قوطة
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Impact of Synonymous Genome Recoding on the HIV Life Cycle
Frontiers in Microbiology, 2021 Synonymous mutations within protein coding regions introduce changes in DNA or messenger (m) RNA, without mutating the encoded proteins. Synonymous recoding of virus genomes has facilitated the identification of previously unknown virus biological ...
Ana Jordan-Paiz +2 more
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Synonymous mutations in representative yeast genes are mostly strongly nonneutral
Nature, 2022 Synonymous mutations in protein-coding genes do not alter protein sequences and are thus generally presumed to be neutral or nearly neutral1–5. Here, to experimentally verify this presumption, we constructed 8,341 yeast mutants each carrying a synonymous,
Xukang Shen +3 more
semanticscholar +1 more source
Synonymous but not Silent: The Codon Usage Code for Gene Expression and Protein Folding
Annual Review of Biochemistry, 2021 Codon usage bias, the preference for certain synonymous codons, is found in all genomes. Although synonymous mutations were previously thought to be silent, a large body of evidence has demonstrated that codon usage can play major roles in determining ...
Yi Liu, Qian Yang, Fangzhou Zhao
semanticscholar +1 more source
Analysis of synonymous codon usage patterns in mitochondrial genomes of nine Amanita species
Frontiers in Microbiology, 2023 Introduction Codon basis is a common and complex natural phenomenon observed in many kinds of organisms. Methods In the present study, we analyzed the base bias of 12 mitochondrial core protein-coding genes (PCGs) shared by nine Amanita species.
Qiang Li +8 more
semanticscholar +1 more source
A novel synonymous KMT2B variant in a patient with dystonia causes aberrant splicing
Molecular Genetics & Genomic Medicine, 2022 Background Heterozygous KMT2B variants are a common cause of dystonia. A novel synonymous KMT2B variant, c.5073C>T (p.Gly1691=) was identified in an individual with childhood‐onset progressive dystonia.
Bianca R. Grosz +13 more
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bioRxiv, 2022 A commonly stated cause of unequal uses of synonymous codons is their differential translational accuracies. A key prediction of this long-standing translational accuracy hypothesis (TAH) of codon usage bias is higher translational accuracies of more ...
Mengyi Sun, Jianzhi Zhang
semanticscholar +1 more source