Results 151 to 160 of about 13,926 (184)

Dulaglutide mitigates inflammatory response in fibroblast-like synoviocytes

International Immunopharmacology, 2019
Rheumatoid arthritis is a common autoimmune disease primarily characterized by chronic inflammation, the formation of an invasive pannus, and destruction of the joints. In the present study, we employed real-time PCR and western blot analysis to investigate the role of dulaglutide in human fibroblast-like synoviocytes (FLS).
Weizhuo, Zheng, Haile, Pan, Li, Wei, Feng, Gao, Xiaozong, Lin   +4 more
openaire   +2 more sources

Telomerase-transduced osteoarthritic fibroblast-like synoviocyte cell line

Biochemical and Biophysical Research Communications, 2004
To examine whether the life span of fibroblast-like synoviocytes (FLSs) can be extended and to establish FLS cell lines that preserve the characteristics of primary FLSs, we introduced human catalytic subunit of telomerase (hTERT) gene into human osteoarthritic (OA) FLSs.
Yubo, Sun, Gary S, Firestein, Leonor, Wenger, Chun-Yuh C, Huang, Herman S, Cheung   +4 more
openaire   +2 more sources

IMMUNOHISTOLOGIC STUDIES OF SYNOVIOCYTES AND SYNOVIAL EXUDATE CELLS

The Journal of Experimental Medicine, 1971
Inclusions were demonstrated in normal polymorphonuclear cells incubated with rheumatoid factor-positive synovial fluid. These stained positively for IgG, IgM, and the ß1C component of complement. When normal polymorphonuclear cells were incubated with factor-negative rheumatoid fluid, inclusions were not obtained.
E R, Hurd, T D, Kinsella, M, Ziff
openaire   +3 more sources

PATHOGENESIS OF RHEUMATOID ARTHRITIS: THE ROLE OF SYNOVIOCYTES

Rheumatic Disease Clinics of North America, 2001
Considering the characteristics of RA synovial tissues such as marked proliferation and invasion to adjacent tissues, comparisons with transformed or neoplastic tissue are natural. RA synovial tissues or cells are not truly malignant, but they have many features of transformation, denoted as "partial transformation" in this article.
Y, Yamanishi, G S, Firestein
openaire   +2 more sources

Regulation of Apoptosis in Rheumatoid Synoviocytes

2002
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by early synovitis following synovial proliferation and infiltration of various inflammatory cells (1,2). The process of disease progression, characterized by activation and hyperplasia of synoviocytes, mainly of synovial fibroblasts, results in cartilage and bone destruction (1,2)
Kusuki Nishioka, Tetsuya Kobayashi
openaire   +1 more source

[Normal synoviocytes and synoviocytes from osteoarthritis and rheumatoid arthritis bind extracellular matrix proteins differently].

Immunitat und Infektion, 1995
Extracellular matrix proteins are increased in inflammatory synovitis. We showed previously that the in situ expression of the corresponding extracellular matrix receptors (beta 1-integrins) is enhanced in synoviocytes (SC) of synovitis of different etiology (16).
N, Rinaldi, T, Barth, P, Leppelmann-Jansen, S, Gansauge, M, Willhauck, R, Berghof, M, Schwarz-Eywill   +6 more
openaire   +1 more source

Intercellular Regulation by Synoviocytes

2022
Geethani Bandara, Christopher H. Evans
openaire   +1 more source

Ultrastructural characteristics of the human synoviocytes.

Bollettino della Societa italiana di biologia sperimentale, 1990
The purpose of this study was to identify, by the scanning electron microscopy, the behaviour of the different cell types in the normal human synovial intima, in order to obtain information useful for interpreting pathological changes in the synovium.
A N, Delrio, M, Fadda
openaire   +1 more source

Fibroblast-like synoviocyte-chondrocyte interaction in cartilage degradation.

Clinical and experimental rheumatology, 2007
In vitro models for joint diseases often focus on a single cell type, such as chondrocytes in osteoarthritis (OA) or fibroblast-like synoviocytes (synoviocytes) in rheumatoid arthritis (RA). However, these joint diseases affect the whole joint and interaction between chondrocytes and synoviocytes may play an important role in disease pathology.
Steenvoorden, M.M.C., Bank, R.A., Ronday, H.K., Toes, R.E.M., Huizinga, T.W.J., DeGroot, J.   +5 more
openaire   +3 more sources

Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes

Nature Reviews Rheumatology, 2020
Gary S Firestein
exaly