Synovial Tissue Sampling in Rheumatological Practice—Past Developments and Future Perspectives
Frontiers in Medicine, 2019 Synovial biopsies are performed in routine clinical care in order to refine diagnosis as well as within a research setting. Progress in the development of minimally invasive synovial sampling methods in the last century has accelerated and facilitated ...
Frances C. Humby
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Frontiers in Immunology, 2022 PurposeRecent studies demonstrated a contribution of adrenoceptors (ARs) to osteoarthritis (OA) pathogenesis. Several AR subtypes are expressed in joint tissues and the β2-AR subtype seems to play a major role during OA progression.
Gundula Rösch +10 more
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Antibiotics with Interleukin-15 inhibition reduces joint inflammation and bone erosions but not cartilage destruction in Staphylococcus aureus-induced arthritis [PDF]
, 2018 Background: Staphylococcus aureus-induced arthritis causes rapid joint destruction, often leading to disabling joint damage despite antibiotics. We have previously shown that IL-15 inhibition without antibiotics is beneficial in S.
Bergmann, Berglind +7 more
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A model of synovial fluid lubricant composition in normal and injured joints [PDF]
European Cells & Materials, 2007 The synovial fluid (SF) of joints normally functions as a biological lubricant, providing low-friction and low-wear properties to articulating cartilage surfaces through the putative contributions of proteoglycan 4 (PRG4), hyaluronic acid (HA), and ...
M E Blewis +4 more
doaj
Frontiers in Immunology, 2023 BackgroundOsteoarthritis (OA) is a common chronic joint disease, but the association between molecular and cellular events and the pathogenic process of OA remains unclear.ObjectiveThe study aimed to identify key molecular and cellular events in the ...
Shengyou Liao +15 more
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c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]
, 2012 The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
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Differential effects of dexamethasone on the chondrogenesis of mesenchymal stromal cells: Influence of microenvironment, tissue origin and growth factor [PDF]
European Cells & Materials, 2011 nchymal stromal cells (MSCs), which reside within various tissues, are utilized in the engineering of cartilage tissue. Dexamethasone (DEX) – a synthetic glucocorticoid – is almost invariably applied to potentiate the growth-factor-induced chondrogenesis
N Shintani, EB Hunziker
doaj
Frontiers in Immunology, 2017 Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects females three times more frequently than males. A potential role for hormones, such as prolactin (PRL), may in part explain this phenomenon.
Man W. Tang +9 more
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CircRNAs in osteoarthritis: research status and prospect
Frontiers in Genetics, 2023 Osteoarthritis (OA) is the most common joint disease globally, and its progression is irreversible. The mechanism of osteoarthritis is not fully understood.
Zhuang Li, Jun Lu
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Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4-α5β1 Axis. [PDF]
Adv Sci (Weinh)Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Deng M +7 more
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