Results 11 to 20 of about 7,336,560 (297)

Structured expert elicitation to inform long-term survival extrapolations using alternative parametric distributions: a case study of CAR T therapy for relapsed/ refractory multiple myeloma

open access: yesBMC Medical Research Methodology, 2022
Background Our aim was to extend traditional parametric models used to extrapolate survival in cost-effectiveness analyses (CEAs) by integrating individual-level patient data (IPD) from a clinical trial with estimates from experts regarding long-term ...
Dieter Ayers   +5 more
doaj   +1 more source

Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production

open access: yesScientific Reports, 2020
The development of targeted drugs for the treatment of cancer remains an unmet medical need. This study was designed to investigate the mechanism underlying breast cancer cell growth suppression caused by fused isoselenazolium salts.
Marina Makrecka-Kuka   +5 more
doaj   +1 more source

Estimated Societal Value of Lecanemab in Patients with Early Alzheimer’s Disease Using Simulation Modeling

open access: yesNeurology and Therapy, 2023
Introduction Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with memory, cognitive, and behavioral deficits, and brings significant economic burden on caregivers and healthcare systems.
Amir Abbas Tahami Monfared   +6 more
doaj   +1 more source

Rats with congenital hydronephrosis show increased susceptibility to renal ischemia‐reperfusion injury

open access: yesPhysiological Reports, 2020
Many drug candidates have shown significant renoprotective effects in preclinical models; however, there is no clinically used effective pharmacotherapy for acute kidney injury.
Reinis Vilskersts   +7 more
doaj   +1 more source

Large-Area Synthesis of High-Quality and Uniform Graphene Films on Copper Foils [PDF]

open access: yesScience, 2009
Growing Graphene The highest quality graphene samples, single-atom-thick layers of carbon, are suspended flakes exfoliated from graphite, but these samples are very small in size (square micrometers).
Xuesong Li   +12 more
semanticscholar   +1 more source

A review on nanoparticles: characteristics, synthesis, applications, and challenges

open access: yesFrontiers in Microbiology, 2023
The significance of nanoparticles (NPs) in technological advancements is due to their adaptable characteristics and enhanced performance over their parent material. They are frequently synthesized by reducing metal ions into uncharged nanoparticles using
Khadijah A. Altammar
semanticscholar   +1 more source

Low‐intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults

open access: yesPhysiological Reports, 2020
Aim Exercise training induces adaptations in muscle and other tissue mitochondrial metabolism, dynamics, and oxidative phosphorylation capacity. Mitochondrial fatty acid oxidation was shown to be pivotal for the anti‐inflammatory status of immune cells ...
Edgars Liepinsh   +9 more
doaj   +1 more source

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors

open access: yesMolecules, 2023
SARS-CoV-2 nsp14 guanine-N7-methyltransferase plays an important role in the viral RNA translation process by catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to viral mRNA cap.
Olga Bobileva   +9 more
doaj   +1 more source

Bispyrenylalkane Chemosensor for the Naked-eye Detection of Nitro-explosives

open access: yesChimica Techno Acta, 2021
Pyrene-based compounds have a great potential as fluorescent chemosensors for various analytes including common nitro-explosives, such as 2,4,6-trinitrotoluene (TNT).
I. S. Kovalev   +8 more
doaj   +1 more source

Bio-inspired synthesis of xishacorenes A, B, and C, and a new congener from fuscol

open access: yesChemical Science, 2019
In this manuscript, we describe the conversion of fuscol, a natural product isolated in 1978, to xishacorenes A, B, and C, isolated in 2017, as well as a previously unreported congener, which we have named xishacorene D.
Alexander R Rovira   +4 more
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy