Results 41 to 50 of about 7,229,609 (313)

May 1,2-Dithiolane-4-carboxylic Acid and Its Derivatives Serve as a Specific Thioredoxin Reductase 1 Inhibitor?

open access: yesMolecules, 2023
Thioredoxin reductase is an essential enzyme that plays a crucial role in maintaining cellular redox homeostasis by catalyzing the reduction of thioredoxin, which is involved in several vital cellular processes.
Anna Nikitjuka   +4 more
doaj   +1 more source

Reactive Synthesis Modulo Theories Using Abstraction Refinement [PDF]

open access: yesarXiv, 2021
Reactive synthesis builds a system from a specification given as a temporal logic formula. Traditionally, reactive synthesis is defined for systems with Boolean input and output variables. Recently, new theories and techniques have been proposed to extend reactive synthesis to data domains, which are required for more sophisticated programs.
arxiv  

Survey on Controlable Image Synthesis with Deep Learning [PDF]

open access: yesarXiv, 2023
Image synthesis has attracted emerging research interests in academic and industry communities. Deep learning technologies especially the generative models greatly inspired controllable image synthesis approaches and applications, which aim to generate particular visual contents with latent prompts.
arxiv  

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

Screening for esophageal adenocarcinoma and precancerous conditions (dysplasia and Barrett’s esophagus) in patients with chronic gastroesophageal reflux disease with or without other risk factors: two systematic reviews and one overview of reviews to inform a guideline of the Canadian Task Force on Preventive Health Care (CTFPHC)

open access: yesSystematic Reviews, 2020
Background Two reviews and an overview were produced for the Canadian Task Force on Preventive Health Care guideline on screening for esophageal adenocarcinoma in patients with chronic gastroesophageal reflux disease (GERD) without alarm symptoms.
Candyce Hamel   +15 more
doaj   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

open access: yesFEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr   +4 more
wiley   +1 more source

Antioxidant activity of 2,6-dimethyl-3,5-dialkoxycarbonyl-1,4-dihydropyridines in metal-ion catalyzed lipid peroxidation

open access: yesCzech Journal of Food Sciences, 2001
Antioxidants with 1,4-dihydropyridine structure were investigated as a less harmful alternative to synthetic phenolic antioxidants in liposomes under conditions simulating food storage.
G. Tirzitis, D. Tirzite, Z. Hyvonen
doaj   +1 more source

Dasymetric population mapping based on US census data and 30-m gridded estimates of impervious surface

open access: yesScientific Data, 2022
Measurement(s) Population Density Technology Type(s) satellite imaging Sample Characteristic - Organism Homo sapiens Sample Characteristic - Environment populated place Sample Characteristic - Location contiguous United States of ...
Rachel H. Swanwick   +5 more
doaj   +1 more source

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

open access: yesFEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley   +2 more
wiley   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

open access: yesFEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung   +6 more
wiley   +1 more source

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