Results 41 to 50 of about 9,706,454 (336)

Synthesis of Graphene on Gold [PDF]

open access: yes, 2011
Here we report chemical vapor deposition of graphene on gold surface at ambient pressure. We studied effects of the growth temperature, pressure and cooling process on the grown graphene layers. The Raman spectroscopy of the samples reveals the essential
Coskun Kocabas   +6 more
core   +2 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures

open access: yesNeurobiology of Disease, 2021
There is a growing body of evidence demonstrating the significant involvement of the sigma-1 chaperone protein in the modulation of seizures. Several sigma-1 receptor (Sig1R) ligands have been demonstrated to regulate the seizure threshold in acute and ...
Edijs Vavers   +9 more
doaj   +1 more source

Finite State Machine Synthesis for Evolutionary Hardware

open access: yes, 2013
This article considers application of genetic algorithms for finite machine synthesis. The resulting genetic finite state machines synthesis algorithm allows for creation of machines with less number of states and within shorter time.
Bereza, Andrey   +2 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition

open access: yesScientific Reports, 2023
Fructosyl peptide oxidases (FPOX) are deglycating enzymes that find application as key enzymatic components in diabetes monitoring devices. Indeed, their use with blood samples can provide a measurement of the concentration of glycated hemoglobin and ...
Hajar Estiri   +8 more
doaj   +1 more source

May 1,2-Dithiolane-4-carboxylic Acid and Its Derivatives Serve as a Specific Thioredoxin Reductase 1 Inhibitor?

open access: yesMolecules, 2023
Thioredoxin reductase is an essential enzyme that plays a crucial role in maintaining cellular redox homeostasis by catalyzing the reduction of thioredoxin, which is involved in several vital cellular processes.
Anna Nikitjuka   +4 more
doaj   +1 more source

SYNTHESIATORS. SOUND SYNTHESIS METHODS

open access: yes, 2022
Modern musical instruments offer ample opportunities for working with writing music in various genres. The device of this or that tool directly affects its quality and characteristics. The article discusses sound synthesis methods that are used in various synthesizers.
N.S. Ananin, B.M. Shtein
openaire   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Machine learning-guided synthesis of advanced inorganic materials

open access: yes, 2019
Synthesis of advanced inorganic materials with minimum number of trials is of paramount importance towards the acceleration of inorganic materials development.
Chouhan, Tushar   +9 more
core   +1 more source

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