Results 31 to 40 of about 2,368,722 (358)
Applications, challenges, and needs for employing synthetic biology beyond the lab
Nature Communications, 2021 Synthetic biology holds great promise for addressing global needs. However, most current developments are not immediately translatable to ‘outside-the-lab’ scenarios that differ from controlled laboratory settings.
Sierra M. Brooks, H. Alper
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A synthetic transcription platform for programmable gene expression in mammalian cells
Nature Communications, 2022 Precise and scalable regulation of gene expression in mammalian cells is challenging. Here, the authors created a highly tunable CRISPR-based synthetic transcription system for programmable control of mammalian gene expression and cellular activity.
William C. W. Chen +13 more
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Synthetic Biology and Computer-Based Frameworks for Antimicrobial Peptide Discovery.
ACS Nano, 2021 Antibiotic resistance is one of the greatest challenges of our time. This global health problem originated from a paucity of truly effective antibiotic classes and an increased incidence of multi-drug-resistant bacterial isolates in hospitals worldwide ...
M. D. Torres +4 more
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Org. Biomol. Chem., 2010 There is currently much excitement surrounding the rapidly growing discipline of synthetic biology, which utilizes the design and construction principles of engineering to develop, evolve and standardize biological components and systems. This systematic approach to improving and increasing the programmability and robustness of biological components is
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Theranostic cells: emerging clinical applications of synthetic biology
Nature reviews genetics, 2021 Synthetic biology seeks to redesign biological systems to perform novel functions in a predictable manner. Recent advances in bacterial and mammalian cell engineering include the development of cells that function in biological samples or within the body
Monica P. McNerney +4 more
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“Cell-Free Synthetic Biology”: Synthetic Biology Meets Cell-Free Protein Synthesis
Methods and Protocols, 2019 Since Nirenberg and Matthaei used cell-free protein synthesis (CFPS) to elucidate the genetic code in the early 1960s [...]
Seok Hoon Hong
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Inducible expression of large gRNA arrays for multiplexed CRISPRai applications
Nature Communications, 2022 CRISPR gene activation and inhibition has become a powerful synthetic tool for influencing the expression of native genes for foundational studies, cellular reprograming, and metabolic engineering.
William M. Shaw +7 more
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Insect pest management in the age of synthetic biology
Plant Biotechnology Journal, 2021 Summary Arthropod crop pests are responsible for 20% of global annual crop losses, a figure predicted to increase in a changing climate where the ranges of numerous species are projected to expand.
Rubén Mateos Fernández +11 more
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Synthetic biology, engineering biology, market expectation
Engineering Biology, 2020 ‘Engineering biology’ is being increasingly adopted as a term by organisations that seek to deliver benefits from ‘synthetic biology’. However, are ‘engineering biology’ and ‘synthetic biology’ different words with the same meaning or do they signal ...
Lionel Clarke
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A machine learning Automated Recommendation Tool for synthetic biology
Nature Communications, 2020 Synthetic biology allows us to bioengineer cells to synthesize novel valuable molecules such as renewable biofuels or anticancer drugs. However, traditional synthetic biology approaches involve ad-hoc engineering practices, which lead to long development
Tijana Radivojević +3 more
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