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Microbial Cell Factories, 2021 Background Saccharomyces cerevisiae is an important synthetic biology chassis for microbial production of valuable molecules. Promoter engineering has been frequently applied to generate more synthetic promoters with a variety of defined characteristics ...
Jiliang Deng +6 more
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Systems biology beyond degree, hubs and scale-free networks: the case for multiple metrics in complex networks [PDF]
Systems and Synthetic Biology (2012) 6:31-34, 2012 Modeling and topological analysis of networks in biological and other complex systems, must venture beyond the limited consideration of very few network metrics like degree, betweenness or assortativity. A proper identification of informative and redundant entities from many different metrics, using recently demonstrated techniques, is essential.
arxiv +1 more source
Models for synthetic biology [PDF]
BMC Systems Biology, 2007 Synthetic biological engineering is emerging from biology as a distinct discipline based on quantification. The technologies propelling synthetic biology are not new, nor is the concept of designing novel biological molecules. What is new is the emphasis on system behavior.
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Biotechnology for Biofuels, 2019 Background Oleaginous yeasts are potent hosts for the renewable production of lipids and harbor great potential for derived products, such as biofuels.
Stefan Bruder +4 more
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Machine learning approaches to predict the Plant-associated phenotype of Xanthomonas strains
BMC Genomics, 2021 Background The genus Xanthomonas has long been considered to consist predominantly of plant pathogens, but over the last decade there has been an increasing number of reports on non-pathogenic and endophytic members.
Dennie te Molder +3 more
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Nature Communications, 2022 The yeast Saccharomyces cerevisiae is powerful for studying human G protein-coupled receptors as they can be coupled to its mating pathway. Here the authors engineer baker’s yeast to produce human sterols and show that vertebrate G protein coupled ...
Björn D. M. Bean +12 more
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A Molecular Implementation of the Least Mean Squares Estimator [PDF]
2016 IEEE 55th Conference on Decision and Control (CDC), 2017 In order to function reliably, synthetic molecular circuits require mechanisms that allow them to adapt to environmental disturbances. Least mean squares (LMS) schemes, such as commonly encountered in signal processing and control, provide a powerful means to accomplish that goal.
arxiv +1 more source
Science Progress, 2014 Although both the most popular form of synthetic biology (SB) and chemical synthetic biology (CSB) share the biotechnologically useful aim of making new forms of life, SB does so by using genetic manipulation of extant microorganism, while CSB utilises classic chemical procedures in order to obtain biological structures which are non-existent in ...
CHIARABELLI, Cristiano, Luisi P.L.
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Landauer in the age of synthetic biology: energy consumption and information processing in biochemical networks [PDF]
, 2015 A central goal of synthetic biology is to design sophisticated synthetic cellular circuits that can perform complex computations and information processing tasks in response to specific inputs. The tremendous advances in our ability to understand and manipulate cellular information processing networks raises several fundamental physics questions: How ...
arxiv +1 more source
Ecological Firewalls for Synthetic Biology
iScience, 2022 While rapidly becoming a main thread in the development of new therapies, the rise of synthetic biology is also tied to concerns about the potential impact on ecosystems. That is particularly relevant in the of deployment in natural habitats, including the human microbiome. These concerns have boosted the analysis of diverse strategies of containment,
Blai Vidiella, Ricard Sole
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