Results 61 to 70 of about 484,138 (208)

Between the possible and the actual: Philosophical perspectives on the design of synthetic organisms

open access: yes, 2013
International audienceA number of research projects in synthetic biology funded by public institutions sound like science fiction: for instance DARPA Biodesign project in 2011 aimed at eliminating "the randomness of natural evolutionary advancement, and ...
Bensaude-Vincent, Bernadette
core   +2 more sources

Misconceptions of Synthetic Biology: Lessons from an Interdisciplinary Summer School [PDF]

open access: yes, 2016
In 2014, an international group of scholars from various fields analysed the "societal dimensions" of synthetic biology in an interdisciplinary summer school. Here, we report and discuss the biologists' observations on the general perception of synthetic
Acevedo-Rocha, Carlos G.   +3 more
core   +2 more sources

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Awareness of and Attitudes Toward Nanotechnology and Synthetic Biology [PDF]

open access: yes, 2008
Based on a survey and focus groups, examines Americans' awareness of nanotechnology and synthetic biology, their initial impressions, and their assessments of the tradeoffs between the potential benefits and ...

core  

BacillOndex: An Integrated Data Resource for Systems and Synthetic Biology [PDF]

open access: yes, 2013
BacillOndex is an extension of the Ondex data integration system, providing a semantically annotated, integrated knowledge base for the model Gram-positive bacterium Bacillus subtilis. This application allows a user to mine a variety of B.
Allenby, Nick   +7 more
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

The Role of Synthetic Biology in NASA's Missions [PDF]

open access: yes
The time has come to for NASA to exploit the nascent field of synthetic biology in pursuit of its mission, including aeronautics, earth science, astrobiology and notably, human exploration.
Rothschild, Lynn J.
core   +1 more source

The impact of synthetic biology in chemical engineering - Educational issues [PDF]

open access: yes, 2012
This paper describes the development of syntheticbiology as a distinct entity from current industrial biotechnology and the implications for a future based on its concepts.
Hall, George M., Howe, Joe
core   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

Synthetic biology—putting engineering into biology [PDF]

open access: yes, 2017
Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias, Panke, Sven
core  

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