Results 61 to 70 of about 2,952,613 (401)

Progression in the In Vitro Macrophage Expansion

Journal of Immunology Research
Macrophages play essential roles in homeostasis and disease, and they were considered terminally differentiated cells that cannot proliferate. However, growing evidence shows that macrophages can self-renew in homeostasis and multiple pathological states
Yunpeng Wei, Jingzhao Yang, Wenhong Zu, Mengran Wang, Yong Zhao   +4 more
doaj   +1 more source

Analog synthetic biology [PDF]

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2014
We analyse the pros and cons of analog versus digital computation in living cells. Our analysis is based on fundamental laws of noise in gene and protein expression, which set limits on the energy, time, space, molecular count and part-count resources needed to compute at a given level of precision.
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Grounding knowledge and normative valuation in agent-based action and scientific commitment [PDF]

, 2018
Philosophical investigation in synthetic biology has focused on the knowledge-seeking questions pursued, the kind of engineering techniques used, and on the ethical impact of the products produced.
A Clark, A Clark, A Clark, A Minelli, A Pickering, B Calcott, B Goodwin, C Kendig, C Kendig, C Kendig, C Swanton, D Dellomonaco, D Endy, D Erwin, D Gibson, D Sprinzak, EF Keller, EJ Lowe, G Wagner, H Chang, H Chang, H Chang, H Chang, H Longino, H-J Rheinberger, I Hacking, I Hacking, J Dupré, J Dupré, J Hornsby, J Rouse, J Rouse, Latour, B./Johnson, J, M Grene, M Grene, M Kirschner, M Morange, M Morange, M O’Malley, M O’Malley, M Polanyi, M West-Eberhard, M West-Eberhard, P Mullins, P Schyfter, R Brent, R Georgianna, R Wilson, TT Eckdahl, VJ Martin, Weihua Wang   +50 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Construction of microbial systems for polyethylene terephthalate degradation

Synthetic and Systems Biotechnology
Polyethylene terephthalate (PET) is one of the most widely used plastic materials, and its large-scale application has caused severe environmental pollution.
Dingkun He, Yichen Gong, Mingzhu Ding, Yingjin Yuan   +3 more
doaj   +1 more source

Misconceptions of Synthetic Biology: Lessons from an Interdisciplinary Summer School [PDF]

, 2016
In 2014, an international group of scholars from various fields analysed the "societal dimensions" of synthetic biology in an interdisciplinary summer school. Here, we report and discuss the biologists' observations on the general perception of synthetic
Acevedo-Rocha, Carlos G., Chizzolini, Fabio, Rothschild, Lynn J., Verseux, Cyprien   +3 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphite synthetic auxotrophy as an effective biocontainment strategy for the industrial chassis Pseudomonas putida

Microbial Cell Factories, 2022
The inclusion of biosafety strategies into strain engineering pipelines is crucial for safe-by-design biobased processes. This in turn might enable a more rapid regulatory acceptance of bioengineered organisms in both industrial and environmental ...
Enrique Asin-Garcia, Christos Batianis, Yunsong Li, James D. Fawcett, Ivar de Jong, Vitor A. P. Martins dos Santos   +5 more
doaj   +1 more source

Plant chemical genetics : from phenotype-based screens to synthetic biology [PDF]

, 2017
The treatment of a biological system with small molecules to specifically perturb cellular functions is commonly referred to as chemical biology. Small molecules are used commercially as drugs, herbicides, and fungicides in different systems, but in ...
Dejonghe, Wim, Russinova, Eugenia
core   +3 more sources