Results 71 to 80 of about 916,052 (349)

Between the possible and the actual: Philosophical perspectives on the design of synthetic organisms

, 2013
International audienceA number of research projects in synthetic biology funded by public institutions sound like science fiction: for instance DARPA Biodesign project in 2011 aimed at eliminating "the randomness of natural evolutionary advancement, and ...
Bensaude-Vincent, Bernadette
core   +2 more sources

Science and Technology Studies in Policy: the UK Synthetic Biology Roadmap [PDF]

, 2019
In this paper, we reflect on our experience as Science and Technology Studies (STS) researchers who were members of the working group that produced A Synthetic Biology Roadmap for the UK in 2012.
Calvert, J., Marris, C.
core   +2 more sources

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Publisher Correction: Encryption and steganography of synthetic gene circuits

Nature Communications, 2019
The original version of this Article contained an error in Fig. 4. In the lower part of the three gene circuit diagrams in panel b, the flat-headed arrow linking lambdaCI to the tetR promoter incorrectly pointed to the tetR gene body.
Oliver Purcell, Jerry Wang, Piro Siuti, Timothy K. Lu   +3 more
doaj   +1 more source

Machine learning approaches to predict the Plant-associated phenotype of Xanthomonas strains

BMC Genomics, 2021
Background The genus Xanthomonas has long been considered to consist predominantly of plant pathogens, but over the last decade there has been an increasing number of reports on non-pathogenic and endophytic members.
Dennie te Molder, Wasin Poncheewin, Peter J. Schaap, Jasper J. Koehorst   +3 more
doaj   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols

Nature Communications, 2022
The yeast Saccharomyces cerevisiae is powerful for studying human G protein-coupled receptors as they can be coupled to its mating pathway. Here the authors engineer baker’s yeast to produce human sterols and show that vertebrate G protein coupled ...
Björn D. M. Bean, Colleen J. Mulvihill, Riddhiman K. Garge, Daniel R. Boutz, Olivier Rousseau, Brendan M. Floyd, William Cheney, Elizabeth C. Gardner, Andrew D. Ellington, Edward M. Marcotte, Jimmy D. Gollihar, Malcolm Whiteway, Vincent J. J. Martin   +12 more
doaj   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Translational synthetic biology [PDF]

Systems and Synthetic Biology, 2015
Synthetic biology is a recent scientific approach towards engineering biological systems from both pre-existing and novel parts. The aim is to introduce computational aided design approach in biology leading to rapid delivery of useful applications. Though the term reprogramming has been frequently used in the synthetic biology community, currently the
Mamta Singh, Anuradha Vaidya
openaire   +3 more sources

Synthetic biology: Understanding biological design from synthetic circuits [PDF]

, 2009
An important aim of synthetic biology is to uncover the design principles of natural biological systems through the rational design of gene and protein circuits.
A Becskei, A Becskei, A Becskei, A Friedland, A Kinkhabwala, A Levskaya, A Raj, A Raj, A Remenyi, A Wagner, AE Tsong, Alexander van Oudenaarden, B Kornmann, B Suess, BJ Yeh, BN Armbruster, BP Prud'homme, C Dugave, C Grilly, C Khosla, CC Guet, CH Martin, CJ Bashor, CL Beisel, D Grate, D Ro, D Rothlisberger, DD Young, DE Nelson, E Fung, E Ozbudak, E Segal, EA Davidson, ED Conrad, EH Davidson, EJ Steen, EM Ozbudak, ES Gilbert, F Jacob, FG Cruz, FJ Isaacs, FJ Isaacs, FK Balagadde, G Werstruck, I Cantone, I Golding, IA Swinburne, J Gerhart, J Gertz, J Gore, J Hasty, J Janin, J Kaplan, J Pedraza, J Stricker, JA Ubersax, JC Anderson, JE Dueber, JM Skerker, JR Pomerening, JR Pomerening, JS Chuang, JS Mattick, JT Bridgham, JT Mettetal, K Brenner, K Hammer, K Harris, K Tatebayashi, L Cai, L You, M Acar, M Behar, M Isalan, M Isalan, M Proft, M Rajendran, M Rapp, M Tigges, M-T Chen, MB Elowitz, MB Elowitz, MN McClean, MN Win, MR Atkinson, MS Antunes, N Geva-Zatorsky, N Rosenfeld, N Rosenfeld, NE Buchler, O Kwon, P Cironi, P Hersen, PL Howard, RJ Taylor, RP Bhattacharyya, RS Cox, S Basu, S Basu, S Hooshangi, S Pokharel, S Shimizu-Sato, SB Cambridge, Shankar Mukherji, SK Desai, T Bulter, T Ellis, TL Deans, TY Tsai, U Alon, Y Setty, Y Tanouchi, YT Maeda, Z Waks   +113 more
core   +1 more source