Results 141 to 150 of about 1,032,308 (279)

Effect of synthetic enantiomeric cannabinoids on platelet aggregation

, 1992
The effect of a synthetic pair of enantiomeric cannabinoids on platelet function was evaluated. The nonpsychotropic enantiomer, the 1,1-dimethylheptyl homolog of (+)-(3S,4S)-7-hydroxy-Δ-6-tetrahydrocannabinol (HU-211), was found to be more active in ...
G. Agam, A. Dvilansky, I. Nathan, A. A. Livne, R. Mechoulam   +4 more
core   +1 more source

Structural and functional insights into rhodopsin‐like and secretin‐like GPCR–arrestin interactions and regulation

The FEBS Journal, EarlyView.
Distinct GPCR phosphorylation barcodes and arrestin conformational states direct arrestin‐mediated signaling and trafficking. The graphical abstract depicts the structural diversity of GPCR–arrestin complexes by overlaying representative core‐engaged and tail‐engaged conformations.
Varsha Gupta, Annette G. Beck‐Sickinger   +1 more
wiley   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Exploring Prison Safety: Insights From Two Decades of HM Inspectorate of Prisons Surveys in England and Wales

The Howard Journal of Crime and Justice, EarlyView.
ABSTRACT This article presents an analysis of surveys conducted by HM Inspectorate of Prisons for England and Wales of 87,449 adult male prisoners between the years 2000 and 2020. It describes the survey methodology and focuses on the 13,025 people who reported feeling unsafe.
Nicholas Hardwick, Kim Reising, Rosie Meek   +2 more
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Gap‐Free Cannabis sativa Assemblies Reveal Post‐Polyploid Genome Remodelling and Refine the Evolution of Cannabinoid Synthase Genes

Plant Biotechnology Journal, EarlyView.
ABSTRACT Despite the therapeutic importance of cannabinoids, the scarcity of gap‐free Cannabis genomes has limited the dissection of the genetic and genomic basis of cannabinoid biosynthesis and genome evolution. Here, we generated two haplotype‐phased, gap‐free, gold‐standard assemblies and used them to investigate post‐polyploid genome remodelling ...
Jiangjiang Zhang, Chuchu Qin, Zhao Li, Lining Zhao, Ashok Biswas, Touming Liu, Mingbao Luan, Lin Li, Defang Li, Jianbin Yan   +9 more
wiley   +1 more source

Biotransformation of monoterpenols upon pre‐treatment with oregano essential oil vapour alleviates downy mildew susceptibility in grapevine leaves

Plant Biology, EarlyView.
Pre‐treatment of grapevine plants with oregano essential oil vapour alleviates downy mildew susceptibility by accumulation of monoterpenol glycosides. Abstract Grapevine downy mildew, caused by the oomycete Plasmopara viticola, is a destructive disease that causes major economic losses as most elite grapevine cultivars are susceptible to this pathogen.
J. R. P. E. Mars, R. M. de Graaf, R. S. Jansen, S. Coolen, P. H. J. Kouwer, J. L. Peters, R. A. Anaia   +6 more
wiley   +1 more source

Chemical Identification of Synthetic Cannabinoids in Herbal Incense Products [PDF]

, 2017
The emergence of synthetic cannabinoids is an ongoing challenge for forensic, clinical analytical chemists and toxicologists. Different analogs are continuously introduced in the market to circumvent the legislation and to enhance their pharmacological ...
Alvarez Heredia, Karol F
core  

Maternal obesity during lactation as a hypertensive cardiovascular risk factor in the offspring

Experimental Physiology, EarlyView.
Abstract Maternal obesity is a major public health concern, with growing evidence supporting its role in the developmental programming of cardiometabolic disease. Although prenatal mechanisms have been investigated extensively, the contribution of lactation as a postnatal window of cardiovascular (CV) programming remains insufficiently understood ...
Gabriela Arenas, Cristián A. Amador, Susana Contreras‐Duarte   +2 more
wiley   +1 more source