Results 211 to 220 of about 1,032,308 (279)

Frontotemporal lobar degeneration therapeutic development pipeline: 2026

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 4, October/December 2026.
Abstract INTRODUCTION Frontotemporal lobar degeneration (FTLD) comprises a group of neuropathological entities underlying a spectrum of clinical syndromes, including behavioral variant frontotemporal dementia, the primary progressive aphasias, progressive supranuclear palsy, and corticobasal syndrome.
Alberto Benussi, Aurora Saccavini, Federica Palacino, Bradley F. Boeve, Adam L. Boxer, Edward D. Huey, Isabelle Le Ber, Raffaella L. Migliaccio, Chiadi U. Onyike, Olivier Piguet, Yolande A. L. Pijnenburg, Jonathan D. Rohrer, James B. Rowe, Eino Solje, Markus Otto, Barbara Borroni, Jeffrey L. Cummings   +16 more
wiley   +1 more source

Noncovalent Interaction-Based Probe Design for PET-Facilitated Fluorescence Sensing of Synthetic Cannabinoids. [PDF]

ACS Omega
Dong J, Zhao C, Ning J, Liu Y, Dou X.
europepmc   +1 more source

Microbiome‐Endocannabinoidome Crosstalk as an Immunometabolic Rheostat in Inflammatory Disease

FASEB BioAdvances, Volume 8, Issue 10, October 2026.
The microbiome‐eCBome axis is operationalized across five measurable domains: microbial functions, compartment‐specific lipid signaling, barrier/translocation, immune‐cell programming, and tissue outcomes. Engineered PEA‐ and OEA‐producing bacteria provide causal proof‐of‐concept, while translation requires tissue‐resolved lipidomics, validated barrier
Reuben S. Maghembe, Donath Damian, Samweli Bahati, Abdalah Makaranga   +3 more
wiley   +1 more source

Classification of Mass Spectral Data to Assist in the Identification of Novel Synthetic Cannabinoids. [PDF]

Molecules
Evans-Newman KC, Schneider GL, Perera NT.   +2 more
europepmc   +1 more source

Trends in new psychoactive substance poisonings in the Netherlands: A 14‐year retrospective analysis (2012–2025)

Addiction, Volume 121, Issue 10, Page 2822-2832, October 2026.
Abstract Background and aims Data on the presence of new psychoactive substances (NPS) mainly originate from drug‐checking, law enforcement and wastewater analysis sources, while data on NPS poisonings are scarce. In Europe, the documented incidence rate of NPS poisonings is highest in the Netherlands.
Johanna J. Nugteren‐van Lonkhuyzen, Irma S. van den Hengel‐Koot, Claudine C. Hunault, Dylan W. de Lange, Antoinette J. H. P. van Riel, Laura Hondebrink   +5 more
wiley   +1 more source

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, Volume 183, Issue 20, Page 6132-6153, October 2026.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Age-specific effects of synthetic cannabinoids on cognitive function and hippocampal gene expression in mice: insights from behavioral and molecular correlates. [PDF]

Front Pharmacol
Li K, Chen Y, Xu Y, Pang Y, Bao Y, Zhang S, Shi X, Ran J, Qiao Y, Xu Y, Wang Y, Di B, Xu P.   +12 more
europepmc   +1 more source

Reln Haploinsufficiency Enhances Fentanyl‐Induced Locomotion and Dorsal Striatal Activity Without Affecting Opioid Reinforcement and Relapse‐Like Behavior

Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.
Reln haploinsufficiency does not alter fentanyl self‐administration, relapse‐like seeking, or conditioned place preference in mice. Instead, reduced Reln expression selectively enhances acute fentanyl‐induced locomotion and dorsal striatal Fos activation, positioning Reelin as a modulator of opioid‐evoked neuronal activity rather than opioid ...
Carl Litif, Avraham M. Libster, Shane Desfor, Tanieng Huang, Leanne Liaw, Annika Cheng, Francesca Telese   +6 more
wiley   +1 more source

Assessment of Abuse Potential of Three Indazole-Carboxamide Synthetic Cannabinoids 5F-ADB, MDMB-4en-PINACA and ADB-4en-PINACA. [PDF]

Int J Mol Sci
Qiao Y, Shi X, Li K, Kuai L, Li X, Di B, Xu P.   +6 more
europepmc   +1 more source

Elucidating and exploring specialised plant metabolism through a pangenomic and pantranscriptomic lens

The Plant Journal, Volume 128, Issue 2, October 2026.
SUMMARY Specialised metabolism is an important factor in how plants cope with biotic and, to a lesser extent, abiotic stress. Current approaches to identify and study the genes involved in such metabolic pathways mainly leverage genomic and transcriptomic datasets of plants, in order to improve our understanding of plant resilience.
Nancy Choudhary, Shakunthala Natarajan, Clara Morweiser, Nele Grünig, Marie Hagedorn, Jakob Franke, Boas Pucker   +6 more
wiley   +1 more source