Results 51 to 60 of about 13,623 (265)

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Illicit Drug‐Derived Volatile Organic Compounds as Markers for Application in Noncontact Detection Technology

The Chemical Record, EarlyView.
This review highlights the characteristic odor markers of illicit drugs, emphasizing volatile markers from both natural and synthetic sources, and explores the shift from canine‐based detection to emerging noncontact sensing technologies. Illicit drug use remains a global concern, requiring effective detection methods to counter evolving concealment ...
Minwoo Kim, Solpa Lee, Anmo J. Kim, Cong Wang, Yongwoo Jang   +4 more
wiley   +1 more source

Bridging the Regulatory Chasm in Investigator‐Initiated Human Subject Cannabis Research

Clinical Pharmacology &Therapeutics, EarlyView.
Heather M. Barkholtz, William Naviaux
wiley   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Vaping Synthetic Cannabinoids: A Novel Preclinical Model of E-Cigarette Use in Mice

Substance Abuse: Research and Treatment, 2017
Smoking is the most common route of administration for cannabis; however, vaping cannabis extracts and synthetic cannabinoids (“fake marijuana”) in electronic cigarette devices has become increasingly popular.
Timothy W Lefever, Julie A Marusich, Brian F Thomas, Daniel G Barrus, Nicholas C Peiper, Richard C Kevin, Jenny L Wiley   +6 more
doaj   +1 more source

Handheld raman spectrometer for the rapid determination of synthetic cannabinoids

Journal of Forensic Science and Medicine, 2019
A handheld laser Raman spectrometer was developed to detect 11 synthetic cannabinoid standards. The spectrometer can be connected with a mobile phone by Bluetooth or a computer by a data cable.
Ling Zhang, Guoping Li
doaj   +1 more source

Drug use among people in prison: A global review of epidemiology, harms and interventions

Addiction, EarlyView.
Abstract Background and aims People who use drugs are overrepresented in the criminal justice system. We aimed to provide a broad synthesis of the epidemiology, harms and interventions related to drug use and drug use disorders among incarcerated adults worldwide, and highlight gaps in evidence and practice.
Louis Favril, John Strang, Seena Fazel
wiley   +1 more source

Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well‐documented intoxication cases and basic pharmacological data

Addiction, EarlyView.
Abstract Background and aims While the health hazards of synthetic cannabinoid receptor agonists (SCRAs) are often approximated using in vitro pharmacological parameters as surrogate, this approach fails to consider pharmacokinetic and pharmacodynamic complexity.
Michaela J. Sommer, Katharina Elisabeth Grafinger, Maren Hermanns‐Clausen, Volker Auwärter   +3 more
wiley   +1 more source

Pharmacological Properties of Synthetic Cannabinoids, Specifics of Their Detection and Forensic Examination

Bulletin of Kharkiv National University of Internal Affairs
The illegal circulation of synthetic cannabinoids intensifies criminal threats and negatively impacts vulnerable segments of the population due to their specific effects on the human psychophysiological state.
O. M. Serdega
doaj   +1 more source

Trends in fentanyl‐containing drug samples seized by law enforcement agencies across Canada

Addiction, EarlyView.
Abstract Background and aims Canada's drug toxicity crisis has been largely attributed to a volatile fentanyl‐dominated unregulated drug supply with increasing reports of fentanyl detected in combination with benzodiazepines, stimulants and xylazine.
Shaleesa Ledlie, Ria Garg, Pamela Leece, Gillian Kolla, Elaine Hyshka, Mina Tadrous, Tara Gomes   +6 more
wiley   +1 more source