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Science, 2019
Frog egg cytoplasm self-organizes into cell-like units by microtubule aster assembly and ...
Timothy J, Mitchison, Christine M, Field
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Frog egg cytoplasm self-organizes into cell-like units by microtubule aster assembly and ...
Timothy J, Mitchison, Christine M, Field
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Synthetic cells in biomedical applications
WIREs Nanomedicine and Nanobiotechnology, 2021AbstractSynthetic cells are engineered vesicles that can mimic one or more salient features of life. These features include directed localization, sense‐and‐respond behavior, gene expression, metabolism, and high stability. In nanomedicine, many of these features are desirable capabilities of drug delivery vehicles but are difficult to engineer.
Wakana Sato +3 more
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Current Opinion in Biotechnology, 2001
Synthesis of data into formal models of cellular function is rapidly becoming a necessary industry. The complexity of the interactions among cellular constituents and the quantity of data about these interactions hinders the ability to predict how cells will respond to perturbation and how they can be engineered for industrial or medical purposes ...
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Synthesis of data into formal models of cellular function is rapidly becoming a necessary industry. The complexity of the interactions among cellular constituents and the quantity of data about these interactions hinders the ability to predict how cells will respond to perturbation and how they can be engineered for industrial or medical purposes ...
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Synthetic Genomics and the Construction of a Synthetic Bacterial Cell
Perspectives in Biology and Medicine, 2012The first synthetic cellular organism was created in 2010 and based on a very small, very simple bacterium called Mycoplasma mycoides . The bacterium was called synthetic because its DNA genome was chemically synthesized rather than replicated from an existing template DNA, as occurs in all other known cellular life on Earth.
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Toward synthetic life: Biomimetic synthetic cell communication
Current Opinion in Chemical Biology, 2021Engineering synthetic minimal cells provide a controllable chassis for studying the biochemical principles of natural life, increasing our understanding of complex biological processes. Recently, synthetic cell engineering has enabled communication between both natural live cells and other synthetic cells.
Abbey O. Robinson +2 more
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Nature, 2010
The “synthetic cell” created by Craig Venter and his colleagues (D. G. Gibson et al. Science doi:10.1126/science.1190719; 2010) is a normal bacterium with a prosthetic genome. As the genome is only about 1% of the dry weight of the cell, only a small part of the cell is synthetic. But the genome is pivotal because it contains the hereditary information
Bedau, Mark +7 more
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The “synthetic cell” created by Craig Venter and his colleagues (D. G. Gibson et al. Science doi:10.1126/science.1190719; 2010) is a normal bacterium with a prosthetic genome. As the genome is only about 1% of the dry weight of the cell, only a small part of the cell is synthetic. But the genome is pivotal because it contains the hereditary information
Bedau, Mark +7 more
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Reconstituting Natural Cell Elements in Synthetic Cells
Advanced Biology, 2021Abstract Building a live cell from non‐living building blocks would be a fundamental breakthrough in biological sciences, and it would enable engineering new lineages of life, not directly descendant of the Last Universal Common Ancestor. Fully engineered synthetic cells will have architectures that can be radically different from the
Nathaniel J. Gaut, Katarzyna P. Adamala
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Physical Biology, 2018
Abstract How do the cells in our body reconfigure their shape to achieve complex tasks like migration and mitosis, yet maintain their shape in response to forces exerted by, for instance, blood flow and muscle action? Cell shape control is defined by a delicate mechanical balance between active force generation and passive material ...
Yuval Mulla +2 more
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Abstract How do the cells in our body reconfigure their shape to achieve complex tasks like migration and mitosis, yet maintain their shape in response to forces exerted by, for instance, blood flow and muscle action? Cell shape control is defined by a delicate mechanical balance between active force generation and passive material ...
Yuval Mulla +2 more
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Devising a divisome for synthetic cells
Nature Reviews ChemistryCell division is a fundamental process essential for life, underpinning reproduction, development and tissue maintenance across all organisms and enabling population growth and evolutionary adaptation. Recreating this capability is, therefore, a central challenge in bottom-up synthetic biology, wherein the aim is to construct functional synthetic cells.
Joris Dommisse +2 more
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Synthetic biology of cell signaling
Natural Computing, 2015Synthetic biology often takes cues from complex natural networks and pathways to create novel biological systems. The design modalities used in synthetic systems generally follow the different classes of gene regulation in cells such as transcriptional, post-transcriptional and post-translational regulation.
Jonathan Hansen, Yaakov Benenson
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