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Restoring NK Cell Cytotoxicity Post‐Cryopreservation via Synthetic Cells [PDF]
Advanced ScienceNatural killer (NK) cells are critical components of the first‐line immune defense, responsible for eliminating tumorigenic cells. NK cell‐based adoptive immunotherapy has gained increasing attention; however, cryopreservation, a standard technique for ...
Xiangda Zhou +20 more
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Building Synthetic Cells─From the Technology Infrastructure to Cellular Entities. [PDF]
ACS Synth BiolThe de novo construction of a living organism is a compelling vision. Despite the astonishing technologies developed to modify living cells, building a functioning cell “from scratch” has yet to be accomplished.
Rothschild LJ +16 more
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Reprogramming Synthetic Cells for Targeted Cancer Therapy
ACS Synthetic Biology, 2022 Advances in synthetic biology enable the reprogramming of bacteria as smart agents to specifically target tumors and locally release anticancer drugs in a highly controlled manner. However, the bench-to-bedside translation of engineered bacteria is often
Boon Huat Lim +5 more
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Synthetic cells with self-activating optogenetic proteins communicate with natural cells
Nature Communications, 2022 Synthetic biology and engineering approaches are harnessed to incorporate new capabilities in synthetic cells. Here, the authors designed bioluminescent signaling mechanisms for intracellular and intercellular synthetic-to-natural cell communication.
Omer Adir +15 more
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Reprogramming cells with synthetic proteins
Asian Journal of Andrology, 2015 Conversion of one cell type into another cell type by forcibly expressing specific cocktails of transcription factors (TFs) has demonstrated that cell fates are not fixed and that cellular differentiation can be a two-way street with many intersections ...
Xiaoxiao Yang, Vikas Malik, Ralf Jauch
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Editorial: Cell-Free Synthetic Biology [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Jian Li +3 more
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Build-a-Cell: Engineering a Synthetic Cell Community
Life, 2021 Build-a-Cell is a global network of researchers that aims to develop synthetic living cells within the next decade. These cells will revolutionize the biotechnology industry by providing scientists and engineers with a more complete understanding of ...
Caroline Frischmon +3 more
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Frontiers in Communications and Networks, 2021 In this Perspective article we intend to focus on the opportunity of modelling Shannon information and/or “semantic” information in the field originated by the convergence of bottom-up synthetic biology (in particular, the construction of “synthetic ...
Maurizio Magarini, Pasquale Stano
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Towards a synthetic cell cycle [PDF]
Nature Communications, 2021 AbstractRecent developments in synthetic biology may bring the bottom-up generation of a synthetic cell within reach. A key feature of a living synthetic cell is a functional cell cycle, in which DNA replication and segregation as well as cell growth and division are well integrated. Here, we describe different approaches to recreate these processes in
Lorenzo Olivi +8 more
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Morphogenesis in Synthetic Chemical Cells [PDF]
The Journal of Physical Chemistry Letters, 2022 We present an efficient model for describing morphogenesis and the emergence of spatiotemporal structures in synthetic chemical cells. This work is motivated by an experimental setup used for testing Turing's theory of morphogenesis. The model developed is based on the general theory of chemically active droplets, which combines the classical theory of
Leonardo Silva-Dias +1 more
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