Results 51 to 60 of about 6,421,082 (286)

Dynamic microcompartmentation in synthetic cells [PDF]

Proceedings of the National Academy of Sciences, 2005
An experimental model for cytoplasmic organization is presented. We demonstrate dynamic control over protein distribution within synthetic cells comprising a lipid bilayer membrane surrounding an aqueous polymer solution. This polymer solution generally exists as two immiscible aqueous phases.
M Scott, Long, Clinton D, Jones, Marcus R, Helfrich, Lauren K, Mangeney-Slavin, Christine D, Keating   +4 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Building a Synthetic Cell Together

Nature Communications
Synthetic cells (SynCells) are artificial constructs designed to mimic cellular functions, offering insights into fundamental biology, as well as promising impact in the fields of medicine, biotechnology, and bioengineering. Achieving a functional SynCell from the bottom up, i.e.
S. Giaveri, Z. Abil, S. Kohyama, M. Fu, A. Levrier, K. Adamala, W. Chinantuya, C. Dekker, N. Deng, J. Fredens, K. Hagino, K. Jahnke, X. Li, A. B. Lindner, C. Liu, S. Majumder, V. Noireaux, P. Schwille, I. N. Westensee   +18 more
openaire   +5 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Synthetic biology

, 2009
There is currently much excitement surrounding the rapidly growing discipline of synthetic biology, which utilizes the design and construction principles of engineering to develop, evolve and standardize biological components and systems. This systematic
Ali Tavassoli, Tavassoli, Ali
core   +1 more source

The Efficacy of Posttreatment with Synthetic C-Reactive Protein in Murine Bacterial Peritonitis via Activation of FcγRI-Expressing Kupffer Cells

Journal of Innate Immunity, 2021
Pretreatment with synthetic C-reactive protein (CRP), a functional CRP peptide, has the potential to augment macrophage phagocytosis by bacterial challenge. However, the posttreatment is clinically ideal.
Manabu Kinoshita, Seigo Ito, Takuya Ishikiriyama, Kumiko Sekiguchi, Ryota Yamaguchi, Ryoichi Tsuruhara, Akihisa Matsuda, Kazuki Koiwa, Masahiro Nakashima, Hiroyuki Nakashima, Masao Miyashita, Shuhji Seki   +11 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Synthetic neuromorphic computing in living cells

Nature Communications, 2022
Computational properties of neuronal networks have been applied to computing systems using simplified models comprising repeated connected nodes. Here the authors create layered assemblies of genetically encoded devices that perform non-binary logic ...
Luna Rizik, Loai Danial, Mouna Habib, Ron Weiss, Ramez Daniel   +4 more
doaj   +1 more source

Synthetic cell research: Is technical progress leaving theoretical and epistemological investigations one step behind?

Frontiers in Robotics and AI, 2023
Advancements in the research on so-called “synthetic (artificial) cells” have been mainly characterized by an important acceleration in all sorts of experimental approaches, providing a growing amount of knowledge and techniques that will shape future ...
Pasquale Stano, Luisa Damiano
doaj   +1 more source