Results 251 to 260 of about 52,872 (276)

Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids

Life Sciences, 2005
The influence of novel synthetic and plant origin flavonoids on activity of multidrug resistance-associated protein (MRP1) was investigated in human erythrocytes used as a cell model expressing MRP1 in plasma membrane. The fluorescent probe, BCPCF (2', 7'-bis-(3-carboxy-propyl)-5-(and-6)-carboxyfluorescein), was applied as a substrate for MRP1 ...
Barbara, Łania-Pietrzak, Krystyna, Michalak, Andrzej B, Hendrich, Daniela, Mosiadz, Grzegorz, Grynkiewicz, Noboru, Motohashi, Yoshiaki, Shirataki   +6 more
openaire   +2 more sources

Synthetic flavonoids cross the placenta in the rat and are found in fetal brain

American Journal of Physiology-Endocrinology and Metabolism, 1998
The synthetic flavonoid EMD-49209 is a potent inhibitor of the in vivo and in vitro binding of thyroxine (T4) to transthyretin (TTR). We studied the distribution of125I-labeled EMD-49209 in maternal tissues, intestinal contents, and fetal tissues in rats that were 20 days pregnant (from 1 to 24 h after intravenous injection).
Schröder-van der Elst, J.P., van der Heide, D., Rokos, H., Morreale de Escobar, G., Köhrle, J.   +4 more
openaire   +3 more sources

Natural and Synthetic Flavonoids as Potent Mycobacterium tuberculosis UGM Inhibitors

Chemistry – A European Journal, 2017
AbstractThis study reports a novel class of inhibitors of uridine 5′‐diphosphate (UDP) galactopyranose mutase (UGM) derived from a screening of natural products. This enzyme is an essential biocatalyst involved in the cell wall biosynthesis of Mycobacterium tuberculosis. Flavonoids are potent inhibitors of UGM.
Sydney A. Villaume, Jian Fu, Inès N'Go, Hui Liang, Huayong Lou, Laurent Kremer, Weidong Pan, Stéphane P. Vincent   +7 more
openaire   +3 more sources

Microcalorimetric investigations of the binding of flavonoids to synthetic and natural membranes.

Thermochimica Acta, 1985
Abstract The binding of flavonoids of different composition and structure to lipid model membranes and to erythrocyte stroma was investigated by microcalorimetric titration measurements. The affinity constants of the various liposome-flavonoid systems investigated vary from 0.3 to 9.6 10 3 1 M −1 , depending on the chemical structure and the ...
M. Luescher-Mattli, E. Marti
openaire   +1 more source

Flavonoid Based Development of Synthetic Drugs: Chemistry and Biological Activities

Chemistry & Biodiversity
AbstractThe toxicity associated with synthetic drugs used for treating various diseases is common. This led to a growing interest in searching and incorporating natural functional core structures such as flavonoid and their derivatives via chemical modifications to overcome the toxicity problems and enhance their biological spectrum.
Rajarshi Nath, Swarup Manna, Shambo Panda, Arindam Maity, Krishnalekha Bandyopadhyay, Arijit Das, Shah Alam Khan, Biplab Debnath, Md Jawaid Akhtar   +8 more
openaire   +2 more sources

Fine tuning of a reported synthetic route for biologically active flavonoid, baicalein

Archives of Pharmacal Research, 2007
A modified procedure of a previous synthetic route for baicalein was developed in order to obtain more than ten grams of baicalein for in vivo test. There were several difficulties in applying the published experimental procedures for a large scale of synthesis.
Sanghee, Kim, Dae Won, Sohn, Youn Chul, Kim, Soon-Ai, Kim, Sang Kook, Lee, Hak Sung, Kim   +5 more
openaire   +2 more sources

New synthetic flavonoids as potent protectors against doxorubicin-induced cardiotoxicity

Free Radical Biology and Medicine, 2001
A series of 3,7-disubstituted-2(3',4'-dihydroxyphenyl) flavones has been studied as potential cardioprotective agents in doxorubicin antitumor therapy. The influence of substituents on the 3 and 7 position of the flavone nucleus on antioxidant activity cytotoxicity and cardioprotective properties was explored to improve the activity of our lead ...
van Acker, F.A.A., Hulshof, J., Haenen, G.R.M.M., Menge, W.M.P.B., van der Vijgh, W.J.F., Bast, A.   +5 more
openaire   +3 more sources

Flavonoid Delivery to the Target Cells through the Synthetic Nanoparticles

2020
In this research, poly (lactide-co-glycolide)-block-poly (ethylene glycol), (PLGA-PEG) nanoparticles (NPs) of less than 195 nm in diameter containing of Naringenin (NRG) a naturally flavonoid were synthesized. Encapsulated form NRG improves its medical properties and solubility.
openaire   +1 more source

A possible mechanistic approach of synthetic flavonoids in the management of pain.

Pakistan journal of pharmaceutical sciences, 2019
Flavonoids are phenolic compounds that have always attracted pharmaceutical researchers and food manufacturers. Nature has indirectly provided us flavones in our daily diet i.e. tea, fruits, juices and vegetables. Flavones have got special position in research field of natural and synthetic organic chemistry due to their biological capabilities.
Mohammad, Shoaib, Syed Wadood Ali, Shah, Niaz, Ali, Naveed, Umar, Ismail, Shah, Shafiullah, -, Muhammad Nawaz, Tahir   +6 more
openaire   +1 more source

LEISHMANICIDAL ACTIVITY OF FLAVONOIDS NATURAL AND SYNTHETIC: A MINIREVIEW

2022
Giani Maria Cavalcante, Amanda Evanile da Silva Cabral, Camila Cássia Silva   +2 more
openaire   +1 more source