Results 271 to 280 of about 91,886 (301)

Natural and Synthetic Flavonoids as Potent Mycobacterium tuberculosis UGM Inhibitors

Chemistry – A European Journal, 2017
AbstractThis study reports a novel class of inhibitors of uridine 5′‐diphosphate (UDP) galactopyranose mutase (UGM) derived from a screening of natural products. This enzyme is an essential biocatalyst involved in the cell wall biosynthesis of Mycobacterium tuberculosis. Flavonoids are potent inhibitors of UGM.
Sydney A. Villaume, Jian Fu, Inès N'Go, Hui Liang, Huayong Lou, Laurent Kremer, Weidong Pan, Stéphane P. Vincent   +7 more
openaire   +3 more sources

Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids

Life Sciences, 2005
The influence of novel synthetic and plant origin flavonoids on activity of multidrug resistance-associated protein (MRP1) was investigated in human erythrocytes used as a cell model expressing MRP1 in plasma membrane. The fluorescent probe, BCPCF (2', 7'-bis-(3-carboxy-propyl)-5-(and-6)-carboxyfluorescein), was applied as a substrate for MRP1 ...
Barbara, Łania-Pietrzak, Krystyna, Michalak, Andrzej B, Hendrich, Daniela, Mosiadz, Grzegorz, Grynkiewicz, Noboru, Motohashi, Yoshiaki, Shirataki   +6 more
openaire   +2 more sources

Fine tuning of a reported synthetic route for biologically active flavonoid, baicalein

Archives of Pharmacal Research, 2007
A modified procedure of a previous synthetic route for baicalein was developed in order to obtain more than ten grams of baicalein for in vivo test. There were several difficulties in applying the published experimental procedures for a large scale of synthesis.
Sanghee, Kim, Dae Won, Sohn, Youn Chul, Kim, Soon-Ai, Kim, Sang Kook, Lee, Hak Sung, Kim   +5 more
openaire   +2 more sources

Flavonoid Based Development of Synthetic Drugs: Chemistry and Biological Activities

Chemistry & Biodiversity
AbstractThe toxicity associated with synthetic drugs used for treating various diseases is common. This led to a growing interest in searching and incorporating natural functional core structures such as flavonoid and their derivatives via chemical modifications to overcome the toxicity problems and enhance their biological spectrum.
Rajarshi Nath, Swarup Manna, Shambo Panda, Arindam Maity, Krishnalekha Bandyopadhyay, Arijit Das, Shah Alam Khan, Biplab Debnath, Md Jawaid Akhtar   +8 more
openaire   +2 more sources

Can semi-synthetic flavonoids return old microglia to their youthful state?

Free Radical Biology and Medicine, 2014
A number of studies have indicated that brain inflammation may deteriorate during normal aging and that neuroinflammation is amplified in age-related neurodegenerative diseases. A pivotal role in age-related neuroinflammatory pathologies is attributed to amplified and prolonged activation of microglia.
Nataša, Mrvová, Marcela, Kuniaková, Vladimír, Knezl, Miroslav, Veverka, Jana, Navarová, Radomír, Nosál, Lucia, Racková   +6 more
openaire   +2 more sources

Natural Flavonoid and Chalcone Scaffolds as Leads for Synthetic Antitubercular Agents

2022
Tuberculosis is a leading cause of mortality and morbidity worldwide, claiming 1.2 million deaths (including 208 000 people with HIV) and 10 million new cases in 2019. Current treatment suffers from significant shortcomings such as length, dosage regimen, toxicity, and resistance development to currently used medicines.
Federico Appetecchia, Mariangela Biava, Giovanna Poce   +2 more
openaire   +1 more source

Flavonoids of the citrus cultivar calamondin and synthetic 2′β-dihydroxychalcones

Phytochemistry, 1978
Abstract Eight methoxyflavones were isolated and identified from the peel of calamondin. Citromitin and 5-O-desmethylcitromitin are actually nobiletin and 5-O-desmethylnobiletin, respectively. 5,6,7,8,3′,4′-Hexamethoxyflavanone and 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavanone are not constituents of calamondin, although previously reported.
James H. Tatum, Robert E. Berry
openaire   +1 more source

Flavonoid Delivery to the Target Cells through the Synthetic Nanoparticles

2020
In this research, poly (lactide-co-glycolide)-block-poly (ethylene glycol), (PLGA-PEG) nanoparticles (NPs) of less than 195 nm in diameter containing of Naringenin (NRG) a naturally flavonoid were synthesized. Encapsulated form NRG improves its medical properties and solubility.
openaire   +1 more source

Natural and synthetic flavonoid derivatives with potential antioxidant and anticancer activities

2009
Die Familie der Flavonoide ist als Naturprodukte sehr gut bekannt und findet sich in einem Großteil der Pflanzenfamilie wieder. Mehr als 8000 verschiedene Flavonoide wurden zum jetzigen Zeitpunkt aus Quellen natürlichen Ursprungs isoliert. Die strukturellen Unterschiede dieser Flavonoide, sowie deren Wirkung gegen Krebs, Schutz vor Krebsentstehung ...
openaire   +1 more source

P33. Synthetic flavonoids as potential antioxidant and antimicrobials

Nitric Oxide, 2008
B.S. Jayashree, Yogendra Nayak
openaire   +1 more source