Results 71 to 80 of about 50,065 (249)

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

Aktivitas Antioksidan dan Fitokimia dari Ekstrak Etil Asetat Pucuk Idat (Cratoxylum glaucum)

Indonesian Journal of Chemical Research, 2018
Neutralizing free radicals can use both synthetic and natural antioxidant compounds. Although synthetic antioxidant compounds are more active, but lately the use of synthetic antioxidants is being reduced because they are reported to have carcinogenic ...
Robby Gus Mahardika, Occa Roanisca
doaj   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Environmentally Friendly Methods for Flavonoid Extraction from Plant Material: Impact of Their Operating Conditions on Yield and Antioxidant Properties

The Scientific World Journal, 2020
The flavonoids are compounds synthesized by plants, and they have properties such as antioxidant, anticancer, anti-inflammatory, and antibacterial, among others.
Sara Luisa Rodríguez De Luna, R. E. Ramírez-Garza, Sergio O. Serna Saldívar   +2 more
doaj   +1 more source

Synthetic flavonoids as potential antiviral agents against SARS-CoV-2 main protease. [PDF]

J Biomol Struct Dyn, 2022
Batool F, Mughal EU, Mughal EU, Zia K, Sadiq A, Naeem N, Javid A, Ul-Haq Z, Saeed M.   +8 more
europepmc   +1 more source

Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants

Advanced Science, EarlyView.
The PS‐QRC nanoprobe employs L‐serine as a targeting ligand for kidney injury molecule‐1 (KIM‐1) to achieve accumulation in injured renal tissues. Upon activation by reactive oxygen species (ROS), it undergoes a self‐amplifying cascade to release fluorophores for near‐infrared fluorescence (NIRF) imaging, enabling ultra‐early diagnosis of acute kidney ...
Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang   +10 more
wiley   +1 more source

Heavy Metal Contamination: Impacts From Plants to the Food Chain and Eco‐Friendly Amelioration Strategies

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Heavy metal pollution reduces soil health and threatens food safety by entering plants; however, the use of nanoparticles, biofertilizers, and organic fertilizers such as biochar offers a promising strategy for improvement and sustainable agriculture. ABSTRACT Heavy metal (HM) pollution, resulting from human activities such as mining and the excessive ...
Sina Siavash Moghaddam, Latifeh Pourakbar, Sevda Alizadeh, Zahra Alizadeh, Jelena Popović‐Djordjević   +4 more
wiley   +1 more source

Improving the Physicochemical Properties, Organic Acids, Amino Acids, Volatile Organic Compounds, and Metabolites of Laohan Melon Juice Through Fermentation With Different Lactic Acid Bacteria

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Fermentation with lactic acid bacteria could improve amino acids, volatile organic compounds (VOCs), and nonvolatile metabolites of Laohan melon juice (LMJ), which provides theoretical guidance for the development of Laohan melon beverage and advances knowledge of the metabolic mechanisms of VOCs in LMJ.
Yun Xie, Sihan Hou, Mingdong Tan, Jianqiao Jiang, Yue Hu, Yiwen Chen, Yongkang Li, Miao Cui, Jianming Niu, Weidong Cheng, Xilei Pu, Yuyun He, Feifei Gao   +12 more
wiley   +1 more source

In vitro Evaluation of the Anti-Picornavirus Activities of New Synthetic Flavonoids

Antiviral Chemistry and Chemotherapy, 1995
Substituted oxazolinylflavons and oxazolinylflavanones were synthesized in order to compare their anti-picornavirus activities with those of related natural and synthetic compounds. The antiviral potencies of the new compounds were evaluated against rhino-virus type 1B and poliovirus type 2 by a plaque reduction assay in HeLa cell cultures.
DESIDERI, Nicoletta, CONTI, Cinzia, Sestili I., Tomao P., STEIN, Maria Luisa, ORSI, Nicola   +5 more
openaire   +2 more sources

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source