Results 251 to 260 of about 1,368,992 (302)

Application of synthetic lipid droplets in metabolic diseases

Clinical and Translational Medicine, 2023
AbstractBackgroundThe study and synthesis of membrane organelles are becoming increasingly important, not only as simplified cellular models for corresponding molecular and metabolic studies but also for applications in synthetic biology of artificial cells and drug delivery vehicles.
Zhuqing Ren
exaly   +4 more sources

Modelling the stratum corneum lipid organisation with synthetic lipid mixtures: the importance of synthetic ceramide composition

Biochimica Et Biophysica Acta - Biomembranes, 2004
Cholesterol (CHOL), free fatty acids (FFA) and nine classes of ceramides (CER1-CER9) form the main constituents of the intercellular lipid lamellae in stratum corneum (SC), which regulate the skin barrier function. Both the presence of a unique 13-nm lamellar phase, of which the formation depends on the presence of CER1, and its dense lateral packing ...
Joke Bouwstra, Gert Gooris, Maria Ponec
exaly   +3 more sources

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Lipid-specific antibodies elicited with synthetic lipid conjugates

Chemistry and Physics of Lipids, 1974
Abstract Antibodies with specificity towards two groups of naturally occurring lipids, namely, cytolipin H and sphingomyelins, respectively, have been elicited by immunization of rabbits with synthetically prepared antigens. The corresponding antigens were conjugates consisting of copolymers of amino acids used as carriers, onto which synthetic lipid
R, Arnon, D, Teitelbaum
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Synthetic peptides: managing lipid disorders

Current Opinion in Lipidology, 2006
Recent publications related to the potential use of synthetic peptides for the management of lipid disorders and their vascular complications are reviewed.The potential use of synthetic peptides for the management of lipid disorders and their vascular complications has emerged in recent years.
Gm, Anantharamaiah, Mohamad, Navab, Srinivasa T, Reddy, David W, Garber, Geeta, Datta, Himanshu, Gupta, C Roger, White, Shaila P, Handattu, Mayakonda N, Palgunachari, Manjula, Chaddha, Vinod K, Mishra, Jere P, Segrest, Alan M, Fogelman   +12 more
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Synthetic Approaches To Heavily Lipidated Phosphoglyceroinositides

Organic Letters, 2003
[reaction: see text] Naturally occurring phosphoinositide glycoconjugates are equipped with varied acyl residues that are important for their biological activity and biosynthesis. This paper reports that acylation at O2 of the myo-inositol moiety can be achieved by stereocontrolled ortho ester rearrangement.
Urs, Schlueter, Jun, Lu, Bert, Fraser-Reid   +2 more
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Synthetic protein lipidation

Current Opinion in Chemical Biology, 2015
Fatty acylation of proteins is a versatile co-translational or post-translational modification that plays a key role in human physiology and disease. It is tightly controlled by a set of enzymes which catalyze the covalent attachment of fatty acids onto protein substrates, resulting in regulation of protein function, stability and interaction with ...
openaire   +2 more sources

Motility of Synthetic Cells from Engineered Lipids

ACS Synthetic Biology, 2023
Synthetic cells are artificial systems that resemble natural cells. Significant efforts have been made over the years to construct synthetic protocells that can mimic biological mechanisms and perform various complex processes. These include compartmentalization, metabolism, energy supply, communication, and gene reproduction.
Jong Hyun Choi, Ruixin Li, Alexander A Swett   +2 more
exaly   +3 more sources

Endotoxic properties of chemically synthesized lipid A part structures. Comparison of synthetic lipid A precursor and synthetic analogues with biosynthetic lipid A precursor and free lipid A

European Journal of Biochemistry, 1984
Synthetic lipid A part structures corresponding structurally to a biosynthetic lipid A disaccharide precursor have been analyzed for endotoxic activity in several systems in vivo and in vitro. It was found that a synthetic beta-1,6-linked D-glucosamine disaccharide, which carries four molar equivalents of (R)-3-hydroxytetradecanoyl residues in ...
Chris GALANOS, Volker LEHMANN, Otto LUDERITZ, Ernst Th. RIETSCHEL, Otto WESTPHAL, Helmut BRADE, Lore BRADE, Marina A. FREUDENBERG, Thomas HANSEN-HAGGE, Thomas LUDERITZ, Gerry McKENZIE, Ulrich SCHADE, Wolfgang STRITTMATTER, Ken-Ichi TANAMOTO, Ulrich ZAHRINGER, Masahiro IMOTO, Hiroyuki YOSHIMURA, Michiharu YAMAMOTO, Tetsuo SHIMAMOTO, Shoichi KUSUMOTO, Tetsuo SHIBA   +20 more
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Synthetic Strategies for Artificial Lipidation of Functional Proteins

Chemistry – A European Journal, 2020
AbstractBiosynthesis of natural lipidated proteins is linked to important signal pathways, and therefore analyzing protein lipidation is crucial for understanding cellular functions. Artificial lipidation of proteins has attracted attention in recent decades as it allows modulation of the amphiphilic nature of the protein of interest, and is used in ...
Mari Takahara, Noriho Kamiya
openaire   +2 more sources

Self-assembling properties of synthetic peptidic lipids

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1993
Novel peptidic lipids were synthesized by the coupling of a linear oligopeptide as the hydrophilic moiety with a glutamic acid dialkylamide as the hydrophobic moiety. Their self-assembling properties were investigated. The critical aggregate concentrations (CAC) for the peptidic lipids with a double dodecyl group were in the range of 1.0 x 10(-5)-3.8 x
T, Shimizu, M, Hato
openaire   +2 more sources