Results 261 to 270 of about 136,463 (299)
Some of the next articles are maybe not open access.
Synthetic Strategies for Artificial Lipidation of Functional Proteins
Chemistry – A European Journal, 2020AbstractBiosynthesis of natural lipidated proteins is linked to important signal pathways, and therefore analyzing protein lipidation is crucial for understanding cellular functions. Artificial lipidation of proteins has attracted attention in recent decades as it allows modulation of the amphiphilic nature of the protein of interest, and is used in ...
Mari Takahara, Noriho Kamiya
openaire +2 more sources
European Journal of Biochemistry, 1984
Synthetic lipid A part structures corresponding structurally to a biosynthetic lipid A disaccharide precursor have been analyzed for endotoxic activity in several systems in vivo and in vitro. It was found that a synthetic beta-1,6-linked D-glucosamine disaccharide, which carries four molar equivalents of (R)-3-hydroxytetradecanoyl residues in ...
Chris GALANOS +20 more
openaire +2 more sources
Synthetic lipid A part structures corresponding structurally to a biosynthetic lipid A disaccharide precursor have been analyzed for endotoxic activity in several systems in vivo and in vitro. It was found that a synthetic beta-1,6-linked D-glucosamine disaccharide, which carries four molar equivalents of (R)-3-hydroxytetradecanoyl residues in ...
Chris GALANOS +20 more
openaire +2 more sources
Current Opinion in Chemical Biology, 2015
Fatty acylation of proteins is a versatile co-translational or post-translational modification that plays a key role in human physiology and disease. It is tightly controlled by a set of enzymes which catalyze the covalent attachment of fatty acids onto protein substrates, resulting in regulation of protein function, stability and interaction with ...
openaire +2 more sources
Fatty acylation of proteins is a versatile co-translational or post-translational modification that plays a key role in human physiology and disease. It is tightly controlled by a set of enzymes which catalyze the covalent attachment of fatty acids onto protein substrates, resulting in regulation of protein function, stability and interaction with ...
openaire +2 more sources
Self-assembling properties of synthetic peptidic lipids
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1993Novel peptidic lipids were synthesized by the coupling of a linear oligopeptide as the hydrophilic moiety with a glutamic acid dialkylamide as the hydrophobic moiety. Their self-assembling properties were investigated. The critical aggregate concentrations (CAC) for the peptidic lipids with a double dodecyl group were in the range of 1.0 x 10(-5)-3.8 x
T, Shimizu, M, Hato
openaire +2 more sources
Controlled Fusion of Synthetic Lipid Membrane Vesicles
Accounts of Chemical Research, 2013Lipid membrane fusion is a fundamental noncovalent transformation as well as a central process in biology. The complex and highly controlled biological machinery of fusion has been the subject of intense investigation. In contrast, fewer synthetic approaches that demonstrate selective membrane fusion have been developed.
Mingming, Ma, Dennis, Bong
openaire +2 more sources
Science, 2016
Chemistry Proteins embedded in cell membranes perform a wide variety of signaling and transport functions through conformational shifts. De Poli et al. examined how a much smaller, simpler construct might begin to achieve similar aims (see the Perspective by Thiele and Ulrich).
openaire +1 more source
Chemistry Proteins embedded in cell membranes perform a wide variety of signaling and transport functions through conformational shifts. De Poli et al. examined how a much smaller, simpler construct might begin to achieve similar aims (see the Perspective by Thiele and Ulrich).
openaire +1 more source
Apolipoprotein/Lipid Interactions: Studies with Synthetic Polypeptide
Critical Reviews in Biochemistry, 1982The understanding of complex interactions which occur in the serum lipoproteins has been greatly aided by using peptide synthesis to obtain fragments of the apolipoproteins which are unobtainable by other means. The results from lipid-binding studies with these synthetic materials have generally supported the amphipathic helical hypothesis of Segrest ...
J T, Sparrow, A M, Gotto
openaire +2 more sources
The inhibition of lecithinase D activity by a synthetic lipid
Archives of Biochemistry and Biophysics, 1962Abstract The synthetic lecithin analog, 2,3-distearoyloxypropyl(dimethyl)-β-hydroxyethyl-ammonium acetate, was a powerful inhibitor of lecithin hydrolysis by Clostridium welchii lecithinase D. A continuous manual electrometric titration at pH 6.9–7.0 was employed.
A F, ROSENTHAL, R P, GEYER
openaire +2 more sources
Adjuvant and antitumour activities of synthetic lipid A analogues
Vaccine, 1986The biological activities of synthetic glycolipids, which were chemically synthesized and based on the structure of lipid A of the lipopolysaccharide (LPS) from Escherichia coli, were examined with special reference to their adjuvant activity on the induction of delayed-type hypersensitivity, activity on the induction of tumour necrotic factor (TNF ...
S, Ukei +4 more
openaire +2 more sources
Disposition of a synthetic analogue of lipid A (E5564) in rats
Xenobiotica, 20031. E5564, a lipid A analogue that potently antagonises lipopolysaccharide, is being developed to treat sepsis caused by Gram-negative bacterial infections. The pharmacokinetic profile of E5564 is independent of dose between 0.1 and 1 mg kg(-1).
K, Kaneko +4 more
openaire +2 more sources