Results 261 to 270 of about 1,368,992 (302)
Some of the next articles are maybe not open access.
Science, 2016
Chemistry Proteins embedded in cell membranes perform a wide variety of signaling and transport functions through conformational shifts. De Poli et al. examined how a much smaller, simpler construct might begin to achieve similar aims (see the Perspective by Thiele and Ulrich).
openaire +1 more source
Chemistry Proteins embedded in cell membranes perform a wide variety of signaling and transport functions through conformational shifts. De Poli et al. examined how a much smaller, simpler construct might begin to achieve similar aims (see the Perspective by Thiele and Ulrich).
openaire +1 more source
Apolipoprotein/Lipid Interactions: Studies with Synthetic Polypeptide
Critical Reviews in Biochemistry, 1982The understanding of complex interactions which occur in the serum lipoproteins has been greatly aided by using peptide synthesis to obtain fragments of the apolipoproteins which are unobtainable by other means. The results from lipid-binding studies with these synthetic materials have generally supported the amphipathic helical hypothesis of Segrest ...
J T, Sparrow, A M, Gotto
openaire +2 more sources
Adjuvant and antitumour activities of synthetic lipid A analogues
Vaccine, 1986The biological activities of synthetic glycolipids, which were chemically synthesized and based on the structure of lipid A of the lipopolysaccharide (LPS) from Escherichia coli, were examined with special reference to their adjuvant activity on the induction of delayed-type hypersensitivity, activity on the induction of tumour necrotic factor (TNF ...
S, Ukei +4 more
openaire +2 more sources
Controlled Fusion of Synthetic Lipid Membrane Vesicles
Accounts of Chemical Research, 2013Lipid membrane fusion is a fundamental noncovalent transformation as well as a central process in biology. The complex and highly controlled biological machinery of fusion has been the subject of intense investigation. In contrast, fewer synthetic approaches that demonstrate selective membrane fusion have been developed.
Mingming, Ma, Dennis, Bong
openaire +2 more sources
The inhibition of lecithinase D activity by a synthetic lipid
Archives of Biochemistry and Biophysics, 1962Abstract The synthetic lecithin analog, 2,3-distearoyloxypropyl(dimethyl)-β-hydroxyethyl-ammonium acetate, was a powerful inhibitor of lecithin hydrolysis by Clostridium welchii lecithinase D. A continuous manual electrometric titration at pH 6.9–7.0 was employed.
A F, ROSENTHAL, R P, GEYER
openaire +2 more sources
Synthetic Lipid- and Lipoprotein Membranes
1971By superimposing monomolecular layers it is possible to arrange molecules in a specific planned order. This method of obtaining simple organized systems of molecules should be of interest to the membranologist as a possible means of building models of biological structures. The possibility of molecular contact between a synthetic monolayer assembly and
openaire +1 more source
Synthetic lipids and their role in defining macromolecular assemblies
Chemistry and Physics of Lipids, 2015Lipids have a variety of physiological roles, ranging from structural and biophysical contributions to membrane functions to signaling contributions in normal and abnormal physiology. This review highlights some of the contributions made by Robert Bittman to our understanding of lipid assemblies through the production of synthetic lipid analogs in the ...
openaire +2 more sources
Fusion of lipid bilayers induced by synthetic lipids and peptides
2009The fusion-inducing properties of three different synthetic lipid derivatives were investigated in model membranes. The results are discussed in terms of membrane destabilization caused by the formation of non-bilayer lipid structures following charge neutralization of the fusogenic components. First, studies on the fusion of large unilamellar vesicles
openaire +1 more source
Bilayer-Forming Synthetic Lipids: Drugs or Carriers?
Current Medicinal Chemistry, 2003Since their introduction as bilayer-forming synthetic compounds in the eighties, dioctadecyldimethylammonium (DODA) and dihexadecylphosphate (DHP) salts have found many uses in strategic, applied areas. In particular, DODA chloride or bromide vesicles interacted with negatively charged prokaryotic or eukaryotic cells, yielding adsorption isotherms of ...
openaire +2 more sources
Anticancer activity of natural and synthetic acetylenic lipids
Lipids, 2006AbstractThis review is a comprehensive survey of acetylenic lipids and their derivatives, obtained from living organisms, that have anticancer activity. Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates.
openaire +2 more sources