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Liposome formation from synthetic polyhydroxyl lipids
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991The preparation of liposomes from synthetic dialkyl amphiphiles is described. Two of these lipids were synthesised with mixed chains of 18:0,14:0 and 18:0,22:0 and one contained two identical alkyl chains of 18:0,18:0. Based on electron microscopic observations and encapsulation studies, liposomes formed from these lipids resemble those prepared from ...
Dean, Taraneh +2 more
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Synthetic Approaches To Heavily Lipidated Phosphoglyceroinositides
Organic Letters, 2003[reaction: see text] Naturally occurring phosphoinositide glycoconjugates are equipped with varied acyl residues that are important for their biological activity and biosynthesis. This paper reports that acylation at O2 of the myo-inositol moiety can be achieved by stereocontrolled ortho ester rearrangement.
Urs, Schlueter +2 more
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Current Opinion in Chemical Biology, 2015
Fatty acylation of proteins is a versatile co-translational or post-translational modification that plays a key role in human physiology and disease. It is tightly controlled by a set of enzymes which catalyze the covalent attachment of fatty acids onto protein substrates, resulting in regulation of protein function, stability and interaction with ...
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Fatty acylation of proteins is a versatile co-translational or post-translational modification that plays a key role in human physiology and disease. It is tightly controlled by a set of enzymes which catalyze the covalent attachment of fatty acids onto protein substrates, resulting in regulation of protein function, stability and interaction with ...
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Self-assembling properties of synthetic peptidic lipids
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1993Novel peptidic lipids were synthesized by the coupling of a linear oligopeptide as the hydrophilic moiety with a glutamic acid dialkylamide as the hydrophobic moiety. Their self-assembling properties were investigated. The critical aggregate concentrations (CAC) for the peptidic lipids with a double dodecyl group were in the range of 1.0 x 10(-5)-3.8 x
T, Shimizu, M, Hato
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Controlled Fusion of Synthetic Lipid Membrane Vesicles
Accounts of Chemical Research, 2013Lipid membrane fusion is a fundamental noncovalent transformation as well as a central process in biology. The complex and highly controlled biological machinery of fusion has been the subject of intense investigation. In contrast, fewer synthetic approaches that demonstrate selective membrane fusion have been developed.
Mingming, Ma, Dennis, Bong
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Science, 2016
Chemistry Proteins embedded in cell membranes perform a wide variety of signaling and transport functions through conformational shifts. De Poli et al. examined how a much smaller, simpler construct might begin to achieve similar aims (see the Perspective by Thiele and Ulrich).
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Chemistry Proteins embedded in cell membranes perform a wide variety of signaling and transport functions through conformational shifts. De Poli et al. examined how a much smaller, simpler construct might begin to achieve similar aims (see the Perspective by Thiele and Ulrich).
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Apolipoprotein/Lipid Interactions: Studies with Synthetic Polypeptide
Critical Reviews in Biochemistry, 1982The understanding of complex interactions which occur in the serum lipoproteins has been greatly aided by using peptide synthesis to obtain fragments of the apolipoproteins which are unobtainable by other means. The results from lipid-binding studies with these synthetic materials have generally supported the amphipathic helical hypothesis of Segrest ...
J T, Sparrow, A M, Gotto
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Synthetic Strategies for Artificial Lipidation of Functional Proteins
Chemistry – A European Journal, 2020AbstractBiosynthesis of natural lipidated proteins is linked to important signal pathways, and therefore analyzing protein lipidation is crucial for understanding cellular functions. Artificial lipidation of proteins has attracted attention in recent decades as it allows modulation of the amphiphilic nature of the protein of interest, and is used in ...
Mari Takahara, Noriho Kamiya
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Bilayer-Forming Synthetic Lipids: Drugs or Carriers?
Current Medicinal Chemistry, 2003Since their introduction as bilayer-forming synthetic compounds in the eighties, dioctadecyldimethylammonium (DODA) and dihexadecylphosphate (DHP) salts have found many uses in strategic, applied areas. In particular, DODA chloride or bromide vesicles interacted with negatively charged prokaryotic or eukaryotic cells, yielding adsorption isotherms of ...
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Novel Phospholipase-Resistant Lipid/Peptide Synthetic Lung Surfactants
Mini-Reviews in Medicinal Chemistry, 2007Animal-derived drugs are currently widely-used to treat clinical lung surfactant deficiency, but synthetic surfactants have significant advantages as pharmaceutical agents. This article examines exogenous surfactants containing novel synthetic phospholipase-resistant lipids of extremely high surface activity.
Robert H, Notter +3 more
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