Results 261 to 270 of about 1,134,240 (310)

Synthetic peptides: managing lipid disorders

Current Opinion in Lipidology, 2006
Recent publications related to the potential use of synthetic peptides for the management of lipid disorders and their vascular complications are reviewed.The potential use of synthetic peptides for the management of lipid disorders and their vascular complications has emerged in recent years.
Gm, Anantharamaiah, Mohamad, Navab, Srinivasa T, Reddy, David W, Garber, Geeta, Datta, Himanshu, Gupta, C Roger, White, Shaila P, Handattu, Mayakonda N, Palgunachari, Manjula, Chaddha, Vinod K, Mishra, Jere P, Segrest, Alan M, Fogelman   +12 more
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Dynamics of lipids in synthetic membranes [PDF]

Pure and Applied Chemistry, 1994
Abstract
exaly   +2 more sources

Synthetic Approaches To Heavily Lipidated Phosphoglyceroinositides

Organic Letters, 2003
[reaction: see text] Naturally occurring phosphoinositide glycoconjugates are equipped with varied acyl residues that are important for their biological activity and biosynthesis. This paper reports that acylation at O2 of the myo-inositol moiety can be achieved by stereocontrolled ortho ester rearrangement.
Urs, Schlueter, Jun, Lu, Bert, Fraser-Reid   +2 more
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Synthetic protein lipidation

Current Opinion in Chemical Biology, 2015
Fatty acylation of proteins is a versatile co-translational or post-translational modification that plays a key role in human physiology and disease. It is tightly controlled by a set of enzymes which catalyze the covalent attachment of fatty acids onto protein substrates, resulting in regulation of protein function, stability and interaction with ...
openaire   +2 more sources

Endotoxic properties of chemically synthesized lipid A part structures. Comparison of synthetic lipid A precursor and synthetic analogues with biosynthetic lipid A precursor and free lipid A

European Journal of Biochemistry, 1984
Synthetic lipid A part structures corresponding structurally to a biosynthetic lipid A disaccharide precursor have been analyzed for endotoxic activity in several systems in vivo and in vitro. It was found that a synthetic beta-1,6-linked D-glucosamine disaccharide, which carries four molar equivalents of (R)-3-hydroxytetradecanoyl residues in ...
Chris GALANOS, Volker LEHMANN, Otto LUDERITZ, Ernst Th. RIETSCHEL, Otto WESTPHAL, Helmut BRADE, Lore BRADE, Marina A. FREUDENBERG, Thomas HANSEN-HAGGE, Thomas LUDERITZ, Gerry McKENZIE, Ulrich SCHADE, Wolfgang STRITTMATTER, Ken-Ichi TANAMOTO, Ulrich ZAHRINGER, Masahiro IMOTO, Hiroyuki YOSHIMURA, Michiharu YAMAMOTO, Tetsuo SHIMAMOTO, Shoichi KUSUMOTO, Tetsuo SHIBA   +20 more
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Synthetic Strategies for Artificial Lipidation of Functional Proteins

Chemistry – A European Journal, 2020
AbstractBiosynthesis of natural lipidated proteins is linked to important signal pathways, and therefore analyzing protein lipidation is crucial for understanding cellular functions. Artificial lipidation of proteins has attracted attention in recent decades as it allows modulation of the amphiphilic nature of the protein of interest, and is used in ...
Mari Takahara, Noriho Kamiya
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Self-assembling properties of synthetic peptidic lipids

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1993
Novel peptidic lipids were synthesized by the coupling of a linear oligopeptide as the hydrophilic moiety with a glutamic acid dialkylamide as the hydrophobic moiety. Their self-assembling properties were investigated. The critical aggregate concentrations (CAC) for the peptidic lipids with a double dodecyl group were in the range of 1.0 x 10(-5)-3.8 x
T, Shimizu, M, Hato
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Apolipoprotein/Lipid Interactions: Studies with Synthetic Polypeptide

Critical Reviews in Biochemistry, 1982
The understanding of complex interactions which occur in the serum lipoproteins has been greatly aided by using peptide synthesis to obtain fragments of the apolipoproteins which are unobtainable by other means. The results from lipid-binding studies with these synthetic materials have generally supported the amphipathic helical hypothesis of Segrest ...
J T, Sparrow, A M, Gotto
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Synthetic twists among lipids

Science, 2016
Chemistry Proteins embedded in cell membranes perform a wide variety of signaling and transport functions through conformational shifts. De Poli et al. examined how a much smaller, simpler construct might begin to achieve similar aims (see the Perspective by Thiele and Ulrich).
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Adjuvant and antitumour activities of synthetic lipid A analogues

Vaccine, 1986
The biological activities of synthetic glycolipids, which were chemically synthesized and based on the structure of lipid A of the lipopolysaccharide (LPS) from Escherichia coli, were examined with special reference to their adjuvant activity on the induction of delayed-type hypersensitivity, activity on the induction of tumour necrotic factor (TNF ...
S, Ukei, J, Iida, T, Shiba, S, Kusumoto, I, Azuma   +4 more
openaire   +2 more sources