Results 271 to 280 of about 271,195 (312)
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Synthetic Strategies for Artificial Lipidation of Functional Proteins
Chemistry – A European Journal, 2020AbstractBiosynthesis of natural lipidated proteins is linked to important signal pathways, and therefore analyzing protein lipidation is crucial for understanding cellular functions. Artificial lipidation of proteins has attracted attention in recent decades as it allows modulation of the amphiphilic nature of the protein of interest, and is used in ...
Mari Takahara, Noriho Kamiya
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Bilayer-Forming Synthetic Lipids: Drugs or Carriers?
Current Medicinal Chemistry, 2003Since their introduction as bilayer-forming synthetic compounds in the eighties, dioctadecyldimethylammonium (DODA) and dihexadecylphosphate (DHP) salts have found many uses in strategic, applied areas. In particular, DODA chloride or bromide vesicles interacted with negatively charged prokaryotic or eukaryotic cells, yielding adsorption isotherms of ...
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Novel Phospholipase-Resistant Lipid/Peptide Synthetic Lung Surfactants
Mini-Reviews in Medicinal Chemistry, 2007Animal-derived drugs are currently widely-used to treat clinical lung surfactant deficiency, but synthetic surfactants have significant advantages as pharmaceutical agents. This article examines exogenous surfactants containing novel synthetic phospholipase-resistant lipids of extremely high surface activity.
Robert H, Notter +3 more
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Calcium‐Responsive Liposomes via a Synthetic Lipid Switch
Chemistry – A European Journal, 2018AbstractLiposomal drug delivery would benefit from enhanced control over content release. Here, we report a novel avenue for triggering release driven by chemical composition using liposomes sensitized to calcium—a target chosen due to its key roles in biology and disease. To demonstrate this principle, we synthesized calcium‐responsive lipid switch 1,
Jinchao Lou +4 more
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Synthetic Lipid- and Lipoprotein Membranes
1971By superimposing monomolecular layers it is possible to arrange molecules in a specific planned order. This method of obtaining simple organized systems of molecules should be of interest to the membranologist as a possible means of building models of biological structures. The possibility of molecular contact between a synthetic monolayer assembly and
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[Lipid synthetic transcription factor, SREBP].
Nihon rinsho. Japanese journal of clinical medicine, 2005SREBP family have been recently established as bHLH type transcription factors governing lipid synthesis. While SREBP-2 regulates expression of genes involved in cholesterol biosynthesis and LDL receptor, SREBP-1c controls fatty acid synthesis. Cellular cholesterol is regulated by feedback system where SCAP/Insig system regulates cleavage of SREBP-2 ...
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Synthetic Lipid Bilayer Membranes
Annual Review of Biochemistry, 1969F A, Henn, T E, Thompson
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Anticancer activity of natural and synthetic acetylenic lipids
Lipids, 2006AbstractThis review is a comprehensive survey of acetylenic lipids and their derivatives, obtained from living organisms, that have anticancer activity. Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates.
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Synthetic erythrocytes from lipid encapsulated hemoglobin.
Experimental hematology, 1981Synthetic erythrocytes have been formed by encapsulating concentrated hemoglobin solutions in microcapsules consisting of phospholipid-cholesterol mixtures. The microcapsules (hemosomes) are of the order of one micron in diameter or smaller, are osmometers, are somewhat sturdier than erythrocytes (RBC), and are stable upon freezing.
L, Djordjevich, I F, Miller
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Synthetic and modified glycerides: effects on plasma lipids
Current Opinion in Lipidology, 2001It has been suggested that the molecular species or structure of the triglyceride, i.e. not only what fatty acids are present but also their relative order in the sn1, 2, or 3 position on the triglyceride, can influence the metabolism of the triglyceride and its fatty acids, including lipoprotein metabolism.
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