Results 61 to 70 of about 911,338 (260)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A Review of the Synthesis, Structural, and Optical Properties of TiO₂ Nanoparticles: Current State of the Art and Potential Applications

Crystals
The manufacturing techniques, structural features, and optical attributes of titanium dioxide (TiO2) nanoparticles are highlighted in this study. These nanoparticles are notable for their remarkable photocatalytic activity, cheap cost, chemical stability,
Mohd Al Saleh Alothoum
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Procyanidins: Structural Properties, Production Methods, and Modern Applications

Molecules
Procyanidins, a class of substances widely distributed in nature, have attracted the attention of the scientific community due to their bioactive properties, especially with regard to human health. This review is based on an extensive examination of peer-
Aleksandr Yu. Zakharov, Dmitriy Berillo, Annie Ng, Damir S. Aidarkhanov, Anna V. Tukesheva, Kamila M. Temirkulova, Ainur Tanybayeva, Zulkhair A. Mansurov, Mannix P. Balanay, Vladimir V. Pavlenko   +9 more
doaj   +1 more source

Microwave Multicomponent Synthesis

Molecules, 2009
In the manner that very important research is often performed by multidisciplinary research teams, the applications of multicomponent reactions involving the combination of multiple starting materials with different functional groups leading to the ...
Helmut M. Hügel
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Synthesis and Thermoelectric Properties of Copper Sulfides via Solution Phase Methods and Spark Plasma Sintering

Crystals, 2017
Large-scale Cu2S tetradecahedrons microcrystals and sheet-like Cu2S nanocrystals were synthesized by employing a hydrothermal synthesis (HS) method and wet chemistry method (WCM), respectively.
Yun-Qiao Tang, Zhen-Hua Ge, Jing Feng
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Métodos de preparação de lactonas de anel médio Methods for the preparation of medium ring lactones

Química Nova, 2007
There are several natural products bearing medium ring lactone moieties, which are those containing a ring size in the range of 8 to 11 members. This review intends to cover the last 10 years (1996-2005) of the literature concerning the synthesis of ...
Luiz S. Longo Junior, Fernanda I. Bombonato, Helena M. C. Ferraz   +2 more
doaj   +1 more source

Optimized Metal Chalcogenides for Boosting Water Splitting

Advanced Science, 2020
Electrocatalytic water splitting (2H2O → 2H2 + O2) is a very promising avenue to effectively and environmentally friendly produce highly pure hydrogen (H2) and oxygen (O2) at a large scale.
Jie Yin, Jing Jin, Honghong Lin, Zhouyang Yin, Jianyi Li, Min Lu, Linchuan Guo, Pinxian Xi, Yu Tang, Chun‐Hua Yan   +9 more
doaj   +1 more source