Results 11 to 20 of about 15,106 (130)

Isolation of SARS-CoV-2 B.1.1.28.2 (P2) variant and pathogenicity comparison with D614G variant in hamster model

Journal of Infection and Public Health, 2022
Background: Considering the potential threat from emerging Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) variants and the rising COVID-19 cases, SARS-CoV-2 genomic surveillance is ongoing in India.
Pragya Yadav, Sreelekshmy Mohandas, Prasad Sarkale, Dimpal Nyayanit, Anita Shete, Rima Sahay, Varsha Potdar, Shrikant Baradkar, Nivedita Gupta, Gajanan Sapkal, Priya Abraham, Samiran Panda, Balram Bhargava   +12 more
doaj   +1 more source

Identification of optimal reference genes in golden Syrian hamster with ethanol‐ and palmitoleic acid‐induced acute pancreatitis using quantitative real‐time polymerase chain reaction

Animal Models and Experimental Medicine, 2023
Background Acute pancreatitis (AP) is a severe disorder that leads to high morbidity and mortality. Appropriate reference genes are important for gene analysis in AP.
Jinxin Miao, Le Kang, Tianfeng Lan, Jianyao Wang, Siqing Wu, Yifan Jia, Xia Xue, Haoran Guo, Pengju Wang, Yan Li   +9 more
doaj   +1 more source

Ad26.COV2.S protects Syrian hamsters against G614 spike variant SARS-CoV-2 and does not enhance respiratory disease

npj Vaccines, 2021
Previously we have shown that a single dose of recombinant adenovirus serotype 26 (Ad26) vaccine expressing a prefusion stabilized SARS-CoV-2 spike antigen (Ad26.COV2.S) is immunogenic and provides protection in Syrian hamster and non-human primate SARS ...
Joan E. M. van der Lubbe, Sietske K. Rosendahl Huber, Aneesh Vijayan, Liesbeth Dekking, Ella van Huizen, Jessica Vreugdenhil, Ying Choi, Miranda R. M. Baert, Karin Feddes-de Boer, Ana Izquierdo Gil, Marjolein van Heerden, Tim J. Dalebout, Sebenzile K. Myeni, Marjolein Kikkert, Eric J. Snijder, Leon de Waal, Koert J. Stittelaar, Jeroen T. B. M. Tolboom, Jan Serroyen, Leacky Muchene, Leslie van der Fits, Lucy Rutten, Johannes P. M. Langedijk, Dan H. Barouch, Hanneke Schuitemaker, Roland C. Zahn, Frank Wegmann   +26 more
doaj   +1 more source

Hamster Polyomavirus Research: Past, Present, and Future

Viruses, 2021
Hamster polyomavirus (Mesocricetus auratus polyomavirus 1, HaPyV) was discovered as one of the first rodent polyomaviruses at the end of the 1960s in a colony of Syrian hamsters (Mesocricetus auratus) affected by skin tumors.
Burkhard Jandrig, Hans Krause, Wolfgang Zimmermann, Emilija Vasiliunaite, Alma Gedvilaite, Rainer G. Ulrich   +5 more
doaj   +1 more source

STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control. [PDF]

PLoS Pathogens, 2015
Human adenoviruses have been studied extensively in cell culture and have been a model for studies in molecular, cellular, and medical biology. However, much less is known about adenovirus replication and pathogenesis in vivo in a permissive host because
Karoly Toth, Sang R Lee, Baoling Ying, Jacqueline F Spencer, Ann E Tollefson, John E Sagartz, Il-Keun Kong, Zhongde Wang, William S M Wold   +8 more
doaj   +1 more source

Infection with Seasonal H1N1 Influenza Results in Comparable Disease Kinetics and Host Immune Responses in Ferrets and Golden Syrian Hamsters

Pathogens, 2023
Animal models of influenza are important in preclinical research for the study of influenza infection and the assessment of vaccines, drugs and therapeutics.
Jemma Paterson, Kathryn A. Ryan, Daniel Morley, Nicola J. Jones, Paul Yeates, Yper Hall, Catherine J. Whittaker, Francisco J. Salguero, Anthony C. Marriott   +8 more
doaj   +1 more source

Chloroquine, an Anti-Malaria Drug as Effective Prevention for Hantavirus Infections

Frontiers in Cellular and Infection Microbiology, 2021
We investigated whether chloroquine can prevent hantavirus infection and disease in vitro and in vivo, using the Hantaan virus newborn C57BL/6 mice model and the Syrian hamster model for Andes virus.
Valentijn Vergote, Lies Laenen, Raf Mols, Patrick Augustijns, Marc Van Ranst, Piet Maes   +5 more
doaj   +1 more source

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

Emerging Microbes and Infections, 2020
Following emergence in late 2019, SARS-CoV-2 rapidly became pandemic and is presently responsible for millions of infections and hundreds of thousands of deaths worldwide.
Kyle Rosenke, Kimberly Meade-White, Michael Letko, Chad Clancy, Frederick Hansen, Yanan Liu, Atsushi Okumura, Tsing-Lee Tang-Huau, Rong Li, Greg Saturday, Friederike Feldmann, Dana Scott, Zhongde Wang, Vincent Munster, Michael A. Jarvis, Heinz Feldmann   +15 more
doaj   +1 more source

Pathogenicity of the SARS-CoV-2 Virus Variants of Concern for the Syrian Golden Hamster

Проблемы особо опасных инфекций, 2022
The aim of the work was to study the pathogenicity of newly emerging variants of SARS-CoV-2 on the model of the Syrian golden hamster.Materials and methods.
A. V. Shipovalov, G. A. Kudrov, A. A. Tomilov, S. A. Bodnev, N. D. Boldyrev, A. S. Ovchinnikova, A. V. Zaikovskaya, O. S. Taranov, E. K. Ivleva, O. V. P’yankov, R. A. Maksyutov   +10 more
doaj   +1 more source

Influenza Viruses Suitable for Studies in Syrian Hamsters

Viruses, 2022
Several small animal models, including mice, Syrian hamsters, guinea pigs, and ferrets are used to study the pathogenicity, transmissibility, and antigenicity of seasonal and pandemic influenza viruses.
Shufang Fan, Chunyang Gu, Huihui Kong, Lizheng Guan, Gabriele Neumann, Yoshihiro Kawaoka   +5 more
doaj   +1 more source