Results 21 to 30 of about 1,320,151 (317)

Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b⁺ cDCs Promotes Pulmonary Tolerance through Downregulation of CD40

Cells, 2020
Activation of the C5/C5a/C5a receptor 1 (C5aR1) axis during allergen sensitization protects from maladaptive T cell activation. To explore the underlying regulatory mechanisms, we analyzed the impact of C5aR1 activation on pulmonary CD11b+ conventional ...
Konstantina Antoniou, Fanny Ender, Tillman Vollbrandt, Yves Laumonnier, Franziska Rathmann, Chandrashekhar Pasare, Harinder Singh, Jörg Köhl   +7 more
doaj   +1 more source

A Tumor-Infiltration CD8+ T Cell-Based Gene Signature for Facilitating the Prognosis and Estimation of Immunization Responses in HPV+ Head and Neck Squamous Cell Cancer

Frontiers in Oncology, 2021
BackgroundCD8+ T cells, which play a vital role in response to adaptive immunity, are closely related to the immunization responses to kill tumor cells.
Yingning Wu, Yingning Wu, Yingning Wu, Lingzhang Meng, Kai Cai, Jingjie Zhao, Siyuan He, Jiajia Shen, Qiuju Wei, Qiuju Wei, Zechen Wang, Suren Sooranna, Hengguo Li, Jian Song, Jian Song   +14 more
doaj   +1 more source

Peripheral inflammation is associated with remote global gene expression changes in the brain [PDF]

, 2014
Background: Although the central nervous system (CNS) was once considered an immunologically privileged site, in recent years it has become increasingly evident that cross talk between the immune system and the CNS does occur. As a result, patients with
Cavanagh, Jonathan, Graham, Gerard J., McColl, Alison, Thomson, Carolyn A.   +3 more
core   +2 more sources

Parkinson's Disease and Systemic Inflammation [PDF]

Parkinson's Disease, 2011
Peripheral inflammation triggers exacerbation in the central brain's ongoing damage in several neurodegenerative diseases. Systemic inflammatory stimulus induce a general response known as sickness behaviour, indicating that a peripheral stimulus can induce the synthesis of cytokines in the brain.
Carina C. Ferrari, Rodolfo Tarelli
openaire   +3 more sources

The Impact of Systemic Inflammation on Neurodevelopment [PDF]

Trends in Molecular Medicine, 2018
Inflammatory mediators affect the brain during development. Neurodevelopmental disorders such as autism spectrum disorders, cognitive impairment, cerebral palsy, epilepsy, and schizophrenia have been linked to early life inflammation. Recent advances have shown the effects of systemic inflammation on children's neurodevelopment.
Nona M, Jiang, Maureen, Cowan, Shannon N, Moonah, William A, Petri   +3 more
openaire   +2 more sources

Bone Marrow Plasma Cells Modulate Local Myeloid-Lineage Differentiation via IL-10

Frontiers in Immunology, 2019
Bone marrow plasma cells have been reported to represent a major source of IL-10; however, the impact of plasma cell derived IL-10 in that tissue remains poorly understood.
Lingzhang Meng, Lingzhang Meng, Larissa Nogueira Almeida, Ann-Katrin Clauder, Timo Lindemann, Julia Luther, Christopher Link, Katharina Hofmann, Upasana Kulkarni, David Ming Wong, Jean-Pierre David, Rudolf Armin Manz   +11 more
doaj   +1 more source

Sarcoidosis-associated hepatocellular carcinoma [PDF]

, 2010
Sarcoidosis is a systemic granulomatous inflammation of unknown etiology, and seems to involve the liver parenchyma in most cases. However, sarcoidosis-associated hepatocellular carcinoma is rare. We report here a case in which a hepatocellular carcinoma
Aiko, Satoshi, Horio, Takuya, Kawai, Toshiaki, Nakanishi, Kuniaki, Ogata, Sho, Saito, Hiroki, Shimazaki, Hideyuki, Sugiura, Yoshiaki   +7 more
core   +1 more source

Laser therapy in superficial morphea lesions – indications, limitations and therapeutic alternatives [PDF]

, 2020
Morphea or localized scleroderma is an uncommon autoimmune and inflammatory disease which affects patients of any age. Even if morphea lesions present systemic symptoms as myalgias or arthritis, it is distinct from systemic sclerosis because it does not ...
Ardeleanu, Valeriu, Constantin, Vlad Denis, Radaschin, Diana Sabina, Stana, Paunica, Tatu, Alin Laurentiu   +4 more
core   +2 more sources

Fcγ Receptor IIB Controls Skin Inflammation in an Active Model of Epidermolysis Bullosa Acquisita

Frontiers in Immunology, 2020
Epidermolysis bullosa acquisita (EBA) is an autoimmune skin blistering disease characterized by IgG autoantibodies (aAb) against type VII collagen (COL7).
Balint Kovacs, Balint Kovacs, Jenny Tillmann, Lisa-Christin Freund, Falk Nimmerjahn, Christian D. Sadik, Katja Bieber, Ralf J. Ludwig, Christian M. Karsten, Jörg Köhl, Jörg Köhl   +10 more
doaj   +1 more source

The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma

Frontiers in Oncology, 2021
BackgroundCD8+ T cells, vital effectors pertaining to adaptive immunity, display close relationships to the immunization responses to kill tumor cells. Understanding the effect exerted by tumor infiltration CD8+ T cells in papillary renal cell carcinoma (
Jie Wang, Jie Wang, Meiying Huang, Meiying Huang, Peng Huang, Jingjie Zhao, Junhua Tan, Feifan Huang, Ruiying Ma, Yu Xiao, Gao Deng, Liuzhi Wei, Liuzhi Wei, Qiuju Wei, Qiuju Wei, Zechen Wang, Siyuan He, Jiajia Shen, Suren Sooranna, Lingzhang Meng, Jian Song, Jian Song   +21 more
doaj   +1 more source