Results 31 to 40 of about 1,320,151 (317)

Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease [PDF]

, 2018
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s ...
Carrillo Jiménez, Alejandro, García Domínguez, Irene, García Revilla, Juan, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Santiago Pavón, Martiniano, Venero Recio, José Luis, Veselá, Karolina   +7 more
core   +3 more sources

Systemic Treatment of Vitreous Inflammation [PDF]

Mediators of Inflammation, 2012
Non infectious vitreous inflammation is often vision threatening and can be associated with potentially life-threatening systemic conditions. Treatment is often challenging as it involves systemic medications that can be associated with adverse effects.
John B. Christoforidis, Susie Chang, Angela Jiang, Jillian Wang, Colleen M. Cebulla   +4 more
openaire   +3 more sources

Transcriptome Profiling Reveals B-Lineage Cells Contribute to the Poor Prognosis and Metastasis of Clear Cell Renal Cell Carcinoma

Frontiers in Oncology, 2021
Although immune therapy can improve the treatment of clear cell renal cell carcinoma (ccRCC) significantly, there are still a large proportion of ccRCC patients who progress to metastasis.
Fafen Yang, Fafen Yang, Jingjie Zhao, Xiuzhuang Luo, Tong Li, Tong Li, Zechen Wang, Qiuju Wei, Qiuju Wei, Heming Lu, Yiliang Meng, Kai Cai, Liuying Lu, Yushi Lu, Lifen Chen, Suren Rao Sooranna, Linxue Luo, Linxue Luo, Jian Song, Jian Song, Lingzhang Meng   +20 more
doaj   +1 more source

Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis [PDF]

, 2018
Subclinical gut inflammation occurring in patients affected by spondyloarthritis (SpA) is correlated with the severity of spine inflammation. Several evidences indicate that dysbiosis occurs in SpA, and that may modulate intestinal permeability and ...
Ciccia F., Ferrante A., Guggino G., Rizzo A.   +3 more
core   +1 more source

Intestinal flora induces depression by mediating the dysregulation of cerebral cortex gene expression and regulating the metabolism of stroke patients

Frontiers in Molecular Biosciences, 2022
Post-stroke depression (PSD) is a common cerebrovascular complication characterized by complex pathogenesis and poor treatment effects. Here, we tested the influence of differentially expressed genes (DEGs), non-targeted metabolites, and intestinal ...
Xuebin Li, Xuebin Li, Guangshun Han, Jingjie Zhao, Xiaohua Huang, Yun Feng, Junfang Huang, Xuequn Lan, Xiaorui Huang, Zechen Wang, Jiajia Shen, Siyuan He, Qiuhao Li, Jian Song, Jian Song, Jie Wang, Jie Wang, Lingzhang Meng, Lingzhang Meng   +18 more
doaj   +1 more source

Effects of probiotics in patients with diabetes mellitus type 2 : study protocol for a randomized, double-blind, placebo-controlled trial [PDF]

, 2013
Background: Low grade chronic inflammation is observed in patients with type 2 diabetes mellitus (T2DM). Endotoxin derived from gut bacteria may act as a potent inflammatory stimulant.
Al-Daghri, Nasser M., Al-Saleh, Yousef, Alkharfy, Khalid M., Alokail, Majed S., McTernan, P. G. (Philip G.), Sabico, Shaun, Vanhoutte, Paul M.   +6 more
core   +3 more sources

Overall Structural Alteration of Gut Microbiota and Relationships with Risk Factors in Patients with Metabolic Syndrome Treated with Inulin Alone and with Other Agents: An Open-Label Pilot Study

Mediators of Inflammation, 2022
Objective. The relative contribution of some products with prebiotic effects, such as inulin, together with medications specific to the human gut microbiome has not been comprehensively studied. The present study determined the potential for manipulating
Ruiping Tian, Jiahui Hong, Jingjie Zhao, Dengyuan Zhou, Yangchen Liu, Zhenshan Jiao, Jian Song, Yu Zhang, Lingzhang Meng, Ming Yu   +9 more
doaj   +1 more source

Complement Has Brains—Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior?

Frontiers in Immunology, 2021
The classical liver-derived and serum-effective complement system is well appreciated as a key mediator of host protection via instruction of innate and adaptive immunity.
Natalia Kunz, Claudia Kemper, Claudia Kemper   +2 more
doaj   +1 more source

Systemic inflammation: Cancer's long-distance reach to maximize metastasis [PDF]

, 2015
While major improvements have been made in targeting primary tumor growth, metastasis and combating cancer spread remain an enigma. We recently identified a systemic inflammatory cascade involving IL17-producing γδ T cells and neutrophils that advance ...
Coffelt, Seth B., de Visser, Karin E.
core   +1 more source

ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages

Journal of Immunology Research, 2022
A disintegrin and metalloprotease 10 (ADAM-10), a member of the ADAM protease family, has biological activities related to TNF-α activation, cell adhesion, and migration, among other functions.
Yan Jiang, Qiming Gong, Jinmei Huang, Yuanxun Gong, Qiang Tang, Dalong Wei, Qianli Tang, Jingjie Zhao, Jian Song, Lingzhang Meng   +9 more
doaj   +1 more source