Results 51 to 60 of about 3,434,192 (362)

Intestinal flora induces depression by mediating the dysregulation of cerebral cortex gene expression and regulating the metabolism of stroke patients

Frontiers in Molecular Biosciences, 2022
Post-stroke depression (PSD) is a common cerebrovascular complication characterized by complex pathogenesis and poor treatment effects. Here, we tested the influence of differentially expressed genes (DEGs), non-targeted metabolites, and intestinal ...
Xuebin Li, Xuebin Li, Guangshun Han, Jingjie Zhao, Xiaohua Huang, Yun Feng, Junfang Huang, Xuequn Lan, Xiaorui Huang, Zechen Wang, Jiajia Shen, Siyuan He, Qiuhao Li, Jian Song, Jian Song, Jie Wang, Jie Wang, Lingzhang Meng, Lingzhang Meng   +18 more
doaj   +1 more source

Overall Structural Alteration of Gut Microbiota and Relationships with Risk Factors in Patients with Metabolic Syndrome Treated with Inulin Alone and with Other Agents: An Open-Label Pilot Study

Mediators of Inflammation, 2022
Objective. The relative contribution of some products with prebiotic effects, such as inulin, together with medications specific to the human gut microbiome has not been comprehensively studied. The present study determined the potential for manipulating
Ruiping Tian, Jiahui Hong, Jingjie Zhao, Dengyuan Zhou, Yangchen Liu, Zhenshan Jiao, Jian Song, Yu Zhang, Lingzhang Meng, Ming Yu   +9 more
doaj   +1 more source

Complement Has Brains—Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior?

Frontiers in Immunology, 2021
The classical liver-derived and serum-effective complement system is well appreciated as a key mediator of host protection via instruction of innate and adaptive immunity.
Natalia Kunz, Claudia Kemper, Claudia Kemper   +2 more
doaj   +1 more source

The Predictive Role of Systemic Inflammation Response Index (SIRI) in the Prognosis of Stroke Patients

Clinical Interventions in Aging, 2021
Purpose Stroke is a disease associated with high mortality. Many inflammatory indicators such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and red blood cell distribution width (RDW) have
Yihui Zhang, Zekun Xing, Kecheng Zhou, Songhe Jiang   +3 more
semanticscholar   +1 more source

ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages

Journal of Immunology Research, 2022
A disintegrin and metalloprotease 10 (ADAM-10), a member of the ADAM protease family, has biological activities related to TNF-α activation, cell adhesion, and migration, among other functions.
Yan Jiang, Qiming Gong, Jinmei Huang, Yuanxun Gong, Qiang Tang, Dalong Wei, Qianli Tang, Jingjie Zhao, Jian Song, Lingzhang Meng   +9 more
doaj   +1 more source

S100A9 Derived From Myeloma Associated Myeloid Cells Promotes TNFSF13B/TNFRSF13B-Dependent Proliferation and Survival of Myeloma Cells

Frontiers in Oncology, 2021
Multiple myeloma (MM) is a lethal hematological malignancy characterized by abundant myeloid cells in the microenvironment that fuel tumor progression. But the mechanism by which myeloid cells support myeloma cells has not been fully explored.
Lingzhang Meng, Lingzhang Meng, Qiang Tang, Jingjie Zhao, Zechen Wang, Liuzhi Wei, Liuzhi Wei, Qiuju Wei, Qiuju Wei, Lianfei Yin, Shiguan Luo, Jian Song, Jian Song   +12 more
doaj   +1 more source

Exploring the Boundaries of Systemic Inflammation* [PDF]

Critical Care Medicine, 2014
Understanding the mechanisms that limit or propagate tissue injury during systemic inflammation may provide the basis for preventing secondary organ dysfunction during serious infections. Endotoxin, an outer membrane component of gram-negative bacteria, is the archetypical microbial factor that mediates inflammation associated with these infections ...
Jason M, Elinoff, Anthony F, Suffredini
openaire   +2 more sources

Tumor-Infiltrated CD8+ T Cell 10-Gene Signature Related to Clear Cell Renal Cell Carcinoma Prognosis

Frontiers in Immunology, 2022
Clear cell renal cell carcinoma (ccRCC) usually affects multiple organs (e.g., bone and brain), and patient prognosis is usually poor. Although it is known that CD8+ T cell infiltration can potentially alleviate ccRCC progression, few studies have ...
Jie Wang, Jie Wang, Feifan Huang, Jingjie Zhao, Peng Huang, Junhua Tan, Meiying Huang, Ruiying Ma, Yu Xiao, Siyuan He, Zechen Wang, Jiajia Shen, Heming Lu, Lingzhang Meng, Lingzhang Meng   +14 more
doaj   +1 more source

Translational Systems Biology of Inflammation

PLoS Computational Biology, 2008
Inflammation is a complex, multi-scale biologic response to stress that is also required for repair and regeneration after injury. Despite the repository of detailed data about the cellular and molecular processes involved in inflammation, including some understanding of its pathophysiology, little progress has been made in treating the severe ...
Yoram Vodovotz, Márie Csete, John Bartels, Steven Chang, Gary An   +4 more
openaire   +4 more sources

The heterogeneity of systemic inflammation in bronchiectasis [PDF]

Respiratory Medicine, 2017
Systemic inflammation in bronchiectasis is poorly studied in relation to aetiology and severity. We hypothesized that molecular patterns of inflammation may define particular aetiology and severity groups in bronchiectasis.We assayed blood concentrations of 31 proteins from 90 bronchiectasis patients (derivation cohort) and conducted PCA to examine ...
Saleh, Aarash D., Chalmers, James D., De Soyza, Anthony, Fardon, Thomas C., Koustas, Spiro O., Scott, Jonathan, Simpson, A. John, Brown, Jeremy S., Hurst, John R.   +8 more
openaire   +4 more sources