Results 11 to 20 of about 32,366 (248)

JAK inhibitors in systemic juvenile idiopathic arthritis

Frontiers in Pediatrics, 2023
ObjectiveSystemic juvenile idiopathic arthritis (SJIA) is characterized by excessive and inappropriate production of proinflammatory cytokines. Janus kinase inhibitors (JAKi) can block the downstream pathway of many cytokines.
Tingyan He, Yu Xia, Ying Luo, Jun Yang
doaj   +3 more sources

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications [PDF]

Annals of the Rheumatic Diseases, 2017
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of conditions unified by the presence of chronic childhood arthritis without an identifiable cause. Systemic JIA (sJIA) is a rare form of JIA characterised by systemic inflammation.
Achkar, JP, Alarcón-Riquelme, ME, Anton, J, Arthur, VL, Baskin, E, Bohnsack, JF, British Society of Pediatric and Adolescent Rheumatology (BSPAR), ., Cobb, J, Demirkaya, E, Docampo, E, Duerr, RH, Estivill, X, Foell, D, Gattorno, M, Grom, AA, Gül, A, Haas, JP, Hilario, MO, Hinks, A, Ilowite, NT, Kamboh, MI, Kastner, DL, Kaufman, KM, Kottyan, LC, Langefeld, CD, Len, C, Martini, A, Mellins, ED, Minden, K, Oliveira, S, Ombrello, MJ, Pinto, D, Prahalad, S, Remmers, EF, Rosen-Wolff, A, Rosenberg, AM, Russo, R, Scherer, SW, Shuldiner, E, Signa, S, Tachmazidou, I, Tenbrock, K, Thompson, S, Thomson, W, Wedderburn, LR, Woo, P, Yeung, RS, Zeft, AS, Zeggini, E, Özen, S   +49 more
core   +12 more sources

Extracellular vesicles in systemic juvenile idiopathic arthritis. [PDF]

J Leukoc Biol, 2023
Abstract Systemic juvenile idiopathic arthritis is a chronic pediatric inflammatory disease of unknown etiology, characterized by fever, rash, hepatosplenomegaly, serositis, and arthritis. We hypothesized that intercellular communication, mediated by extracellular vesicles, contributes to systemic juvenile idiopathic arthritis ...
Maller J, Morgan T, Morita M, McCarthy F, Jung Y, Svensson KJ, Elias JE, Macaubas C, Mellins E.   +8 more
europepmc   +3 more sources

Does systemic-onset juvenile idiopathic arthritis belong under juvenile idiopathic arthritis? [PDF]

Rheumatology, 2005
'Science is the systematic classification of experience' George Henry Lewes (1817-78), English philosopher, critic, dramatist, scientist. Juvenile idiopathic arthritis (JIA) is prevalent in about 1 in 1000 children. The earliest formal description of this disease was by Sir George Frederick Still in 1897.
Ramanan, AV, Grom, AA
openaire   +3 more sources

Glucose metabolism in systemic juvenile idiopathic arthritis

Pediatric Rheumatology, 2022
Abstract Background Systemic juvenile idiopathic arthritis (SJIA) is a chronic systemic inflammatory disease in children. Overproduction of inflammatory cytokines in SJIA resembles that in adult onset Still disease. Chronic inflammation causes insulin resistance and consequently leading to abnormal glucose metabolism ...
Papatsorn Suppasit, Soamarat Vilaiyuk, Preamrudee Poomthavorn, Sarunyu Pongratanakul, Patcharin Khlairit, Pat Mahachoklertwattana   +5 more
openaire   +3 more sources

Histopathology of the gut in rheumatic diseases [PDF]

, 2018
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F., Ferrante A., Guggino G., Macaluso F., Rizzo A.   +4 more
core   +1 more source

Sustained hyperferritinemia in a child with macrophage activation syndrome secondary to systemic juvenile idiopathic arthritis - perforinopathy: case based review

The Turkish Journal of Pediatrics, 2018
Systemic juvenile idiopathic arthritis is a subtype of juvenile idiopathic arthritis and characterized by arthritis and many systemic features like fever, rash, hepatosplenomegaly, lymphadenopathy and serositis.
Mustafa Çakan, Nuray Aktay-Ayaz, Hakan Gemici, Agageldi Annayev, Agop Çıtak, Arzu Akçay, Gülyüz Öztürk   +6 more
doaj   +1 more source

Emerging patterns of genetic overlap across autoimmune disorders. [PDF]

, 2012
Most of the recently identified autoimmunity loci are shared among multiple autoimmune diseases. The pattern of genetic association with autoimmune phenotypes varies, suggesting that certain subgroups of autoimmune diseases are likely to share ...
Criswell, Lindsey A, Richard-Miceli, Corinne   +1 more
core   +1 more source

Clinical and Laboratory Profile of Patients with Newly Diagnosed Juvenile Idiopathic Arthritis: An Observational Study from a Tertiary Care Centre, Karnataka, India [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Juvenile Idiopathic Arthritis (JIA) is the most common rheumatic condition of childhood. It represents a heterogeneous group of childhood arthritis.
Sivaranjani Sethupandi, Daasara Gururaju, Anand Prahalad Rao, Nijaguna Nanjundappa   +3 more
doaj   +1 more source

CLINICAL CASE OF TOCILIZUMAB USE IN A PATIENT WITH SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS

Педиатрическая фармакология, 2014
The article presents a case of successful use of a preparation of monoclonal antibodies to interleukin 6 receptors (tocilizumab) at asevere systemic juvenile idiopathic arthritis.
O. L. Lomakina, E. I. Alexeyeva, R. V. Denisova, T. V. Sleptsova, A. N. Fetisova   +4 more
doaj   +1 more source