Results 241 to 250 of about 25,508,313 (370)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

An integrative systems-biology approach defines mechanisms of Alzheimer's disease neurodegeneration. [PDF]

Nat Commun
Leventhal MJ, Zanella CA, Kang B, Peng J, Gritsch D, Liao Z, Bukhari H, Wang T, Pao PC, Danquah S, Benetatos J, Nehme R, Farhi S, Tsai LH, Dong X, Scherzer CR, Feany MB, Fraenkel E.   +17 more
europepmc   +1 more source

Data Integration and Analysis for Medical Systems Biology [PDF]

, 2004
Hans van Beek
openalex   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Systems biology: A primer [PDF]

NeuroRX, 2006
Timothy R. Mhyre, Howard J. Federoff
openaire   +3 more sources

Editorial: Natural products and immune inflammation: mechanistic understanding based on systems biology. [PDF]

Front Pharmacol
Ma Z, Li X.
europepmc   +1 more source

Network approaches to systems biology analysis of complex disease: integrative methods for multi-omics data

Briefings Bioinform., 2017
Jingwen Yan, S. Risacher, Li Shen, A. Saykin   +3 more
semanticscholar   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Systems biology approaches investigating mitochondrial dysfunction in cyanotic heart disease: a systematic review. [PDF]

EBioMedicine
Elbatarny M, Lu YT, Hu M, Coles J, Mital S, Ross-White A, Honjo O, Barron DJ, Gramolini AO.   +8 more
europepmc   +1 more source

Pollination and Reproductive Biology of Twelve Species of Neotropical Malpighiaceae: Stigma Morphology and its Implications for the Breeding System [PDF]

, 2004
Maria Rosângela Sigrist
openalex   +1 more source