Results 191 to 200 of about 323,783 (333)

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source

Thirteen-week nose-only inhalation exposures of propylene glycol aerosols in Sprague Dawley rats with a lung systems toxicology analysis

, 2021
Timothy B. Langston, James Randazzo, Ulrike Kogel, Julia Hoeng, Florian Martin, Bjoern Titz, Emmanuel Guedj, Thomas Schneider, B.T. Prabhakar, J Zhang, Michael J. Oldham, Kyung‐Mi Lee   +11 more
openalex   +2 more sources

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

A systems toxicology approach implicates post-transcriptional regulatory networks in reproductive defects from PFAS exposure. [PDF]

Toxicol Sci
Bline AP, Jiang H, Levenson M, Allard P.
europepmc   +1 more source

A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro. [PDF]

Toxicol Sci, 2019
Ramm S, Todorov P, Chandrasekaran V, Dohlman A, Monteiro MB, Pavkovic M, Muhlich J, Shankaran H, Chen WW, Mettetal JT, Vaidya VS.   +10 more
europepmc   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Mitigating Trastuzumab-Doxorubicin Cardiotoxicity With Multiscale Quantitative Systems Toxicology and PBPK-Toxicodynamic Predictive Modeling Framework. [PDF]

CPT Pharmacometrics Syst Pharmacol
Yu S, Mody H, Vaidya TR, Kagan L, Ait-Oudhia S.   +4 more
europepmc   +1 more source

Biology and Toxicology of Gametes, Embryos, and Cancer Cells in Reproductive Systems [PDF]

Min Ju Kang, Byeongseok Kim, Youngsok Choi   +2 more
openalex   +1 more source

Toward a Blended Ontology: Applying Knowledge Systems to Compare Therapeutic and Toxicological Nanoscale Domains [PDF]

, 2012
Chris Grulke, Michael‐Rock Goldsmith, Daniel A. Vallero   +2 more
openalex   +1 more source

Toxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug

, 2021
Byung Chull An, Yeo-Sang Yoon, Ho Jin Park, Sangkyun Park, Tai Yeub Kim, Jun Young Ahn, Daebeom Kwon, Oksik Choi, Jin Young Heo, Yongku Ryu, Joong-Hyun Kim, Heejong Eom, Myung Jun Chung   +12 more
openalex   +2 more sources