Differential expression of cancer-related genes supports prediction of poor response to first-line treatments in T-ALL pediatric patients with high minimal residual disease. [PDF]
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Lahera A +11 more
europepmc +2 more sources
Distinguishing T-lymphoblastic leukemia/lymphoma (T-ALL/T-LBL) from thymomas (especially B1 or B2 type) can be challenging particularly in limited trucut biopsy material where appreciating architecture is difficult or the background epithelial component ...
Divya Bansal +6 more
doaj +1 more source
PB1703: MODELING T-CELL DEVELOPMENT AND T-ALL INITIATION [PDF]
Advaita M Dick +4 more
doaj +2 more sources
Evaluation of aberrant expression of CD markers in acute leukemia cells
Background and objective: Worldwide immunophenotyping by flow cytometry (FCM) in acute leukemia (AL) is the golden step in the diagnosis. It’s very common for acute leukemias to aberrantly express antigens or cluster of differentiation (CD) markers which
Lava kareem Shwani +2 more
doaj +1 more source
Background: In today’s generation of targeted therapy, traditional reporting of acute leukemia by morphology using the FAB system of classification has limited uses due to a lack of standardization and use in risk stratification.
Chaitali Patnaik +3 more
doaj +1 more source
Mycotoxins, pesticides and heavy metals content in the winter wheat grain at different cultivation technologies on leached Kuban chernozem [PDF]
The influence of fertilizers and plant protection products for the mycotoxins, pesticides and heavy metals accumulation in the grain of winter wheat variety Antonina grown at the experimental station of the Kuban University was investigated.
Shabanova Irina +3 more
doaj +1 more source
In the current issue of Blood, Degryse and coauthors report the transforming potential of a series of JAK3 mutations identified in primary T-cell acute lymphoblastic leukemia (T-ALL) samples and pave the way toward multitargeted JAK1 and JAK3 therapy in T-ALL.
openaire +2 more sources
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive subset of ALL with poor clinical outcome compared to B-ALL. Therefore, to improve treatment, it is imperative to delineate the molecular blueprint of this disease. This review describes the central role that the Notch pathway plays in T-ALL development.
R M, Demarest, F, Ratti, A J, Capobianco
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Clinical and molecular characterization of early T-cell precursor leukemia : a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations [PDF]
A subgroup of pediatric acute T-lymphoblastic leukemia (T-ALL) was characterized by a gene expression profile comparable to that of early T-cell precursors (ETPs) with a highly unfavorable outcome.
Hoelzer, Dieter +12 more
core +1 more source
The longicorn beetle genus Trypogeus Lacordaire, 1869 (Coleoptera: Cerambycidae) in Vietnam, with descriptions of three new species [PDF]
All four species of the genus Trypogeus Lacordaire, 1869 currently known from Vietnam are discussed. Three of them, namely, T. taynguyensis sp. n., T. pygmaeus sp. n. and T. tonkinensis sp. n., are described as new.
A.I. Miroshnikov
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