Results 21 to 30 of about 30,760,761 (278)

WT1 mutations in T-ALL

Blood, 2009
The molecular mechanisms involved in disease progression and relapse in T-cell acute lymphoblastic leukemia (T-ALL) are poorly understood. We used single nucleotide polymorphism array analysis to analyze paired diagnostic and relapsed T-ALL samples to identify recurrent genetic alterations in T-ALL.
TOSELLO V, MANSOUR MR, BARNES K, PAGANIN, MADDALENA, SULIS ML, JENKINSON S, ALLEN CG, GALE RE, LINCH DC, PALOMERO T, REAL P, MURTY V, YAO XP, RICHARDS SM, GOLDSTONE A, ROWE J, BASSO, GIUSEPPE, WIERNIK PH, PAIETTA E, PIETERS R, HORSTMANN M, MEIJERINK JPP, FERRANDO AA   +22 more
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T-ALL: Home Is where the CXCL12 Is [PDF]

Cancer Cell, 2015
T cell acute lymphoblastic leukemia (T-ALL) is caused by mutations affecting cell survival, proliferation, and differentiation. In addition to requiring these mutations, Passaro and colleagues and Pitt and colleagues in this issue of Cancer Cell demonstrate that T-ALL initiating cells residing in bone marrow depend on the CXCR4/CXCL12 signaling axis ...
de Bock, Charles E., Cools, Jan
openaire   +2 more sources

Calcineurin/CXCR4 in T-ALL

Oncoscience, 2015
The calcineurin/NFAT signaling pathway is implicated in a wide variety of biological processes, acting as a bridge pathway between calcium signals and gene expression. Although its role as an effector of immune responses figured prominently in early studies, it forms just one part of a larger picture. Indeed calcineurin has been shown to participate in
Diana, Passaro, Christine Tran, Quang, Jacques, Ghysdael   +2 more
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Dicing up T-ALL [PDF]

Blood, 2015
In this issue of Blood, Junker et al delineate a novel signaling axis involving miR-21 and the tumor suppressor Pdcd4 that is essential for Notch-mediated induction of T-cell acute lymphoblastic leukemia (T-ALL).
openaire   +2 more sources

Evaluation of Onion (Allium cepa L.) Genotypes for Tolerance to Thrips (Thrips tabaci L.) and Purple Blotch [Alternaria porri (Ellis) Ciferri]

International Journal of Bio-Resource and Stress Management, 2023
The study was conducted in onion to identify the advanced lines or varieties tolerant to onion thrips and/or purple blotch disease with high yield potential.
P. Tripathy, A. Priyadarshini, S. K. Das,, B. B. Sahoo, D. K. Dash   +4 more
doaj  

Targeting hedgehog in T-ALL [PDF]

Blood, 2016
Leukemia is a developmental disease of the hematopoietic system. In this issue of Blood, Dagklis et al1 identified hyperactivation of the hedgehog developmental pathway in a subgroup of T-cell acute lymphoblastic leukemias (T-ALLs). Given the availability of US Food and Drug Administration (FDA)–approved hedgehog-inhibiting drugs and the extremely poor
openaire   +2 more sources

PTEN and AKT1 Variations in Childhood T-Cell Acute Lymphoblastic Leukemia

Turkish Journal of Hematology, 2020
Objective: PTEN/AKT pathway deregulations have been reported to be associated with treatment response in acute leukemia. This study examined pediatric T-cell acute lymphoblastic leukemia (T-ALL) samples for PTEN and AKT1 gene variations and evaluated the
Fulya Küçükcankurt, Yücel Erbilgin, Sinem Fırtına, Özden Hatırnaz Ng, Zeynep Karakaş, Tiraje Celkan, Ayşegül Ünüvar, Uğur Özbek, Müge Sayitoğlu   +8 more
doaj   +1 more source

Exploring the pharmacological mechanisms of Shuanghuanglian against T-cell acute lymphoblastic leukaemia through network pharmacology combined with molecular docking and experimental validation

Pharmaceutical Biology, 2023
Context Due to the poor prognosis of T-cell acute lymphoblastic leukaemia (T-ALL), there is an urgent need to identify safer and more cost-effective drugs.Objective This study evaluated the antitumour activity of Shuanghuanglian (SHL) on T-ALL cells and ...
You Yang, Yan Yang, Yunfu Shen, Jing Liu, Yan Zeng, Chengming Wei, Chunyan Liu, Yansha Pan, Qulian Guo, Fangfang Zhong, Ling Guo, Wenjun Liu   +11 more
doaj   +1 more source

Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival

Hematology, Transfusion and Cell Therapy, 2020
Background and objective: T-cell acute lymphoblastic leukemia (T-ALL) in children represents a high-risk disease. There is a lack of studies assessing the outcome of T-ALL in Hispanic populations, in which it is a rare malignancy.
José Carlos Jaime-Pérez, José Antonio Hernández-de los Santos, David Gómez-Almaguer   +2 more
doaj   +1 more source

Upregulation of T-Cell-Specific Transcription Factor Expression in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Turkish Journal of Hematology, 2012
OBJECTIVE: T-cell acute lymphoblastic leukemia (T-ALL) is associated with recurrent chromosomal aberrations and abnormal ectopic gene expression during T-cell development.
Müge Sayitoğlu, Yücel Erbilgin, Özden Hatırnaz, İnci Yıldız, Tiraje Celkan, Sema Anak, Ömer Devecioğlu, Gönül Aydoğan, Serap Karaman, Nazan Sarper, Çetin Timur, Ümit Üre, Uğur Özbek   +12 more
doaj   +1 more source