Results 31 to 40 of about 30,760,761 (278)

Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL

Journal of Hematology & Oncology, 2021
IDH1 and IDH2 mutations (IDH1/2 Mut ) are recognized as recurrent genetic alterations in acute myeloid leukemia (AML) and associated with both clinical impact and therapeutic opportunity due to the recent development of specific IDH1/2 Mut inhibitors. In
Mathieu Simonin, Aline Schmidt, Christophe Bontoux, Marie-Émilie Dourthe, Etienne Lengliné, Guillaume P. Andrieu, Ludovic Lhermitte, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Françoise Huguet, Isabelle Arnoux, Stéphane Ducassou, Elizabeth Macintyre, Virginie Gandemer, Hervé Dombret, Arnaud Petit, Norbert Ifrah, André Baruchel, Nicolas Boissel, Vahid Asnafi   +20 more
doaj   +1 more source

The genetics and molecular biology of T-ALL [PDF]

Blood, 2017
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy caused by the accumulation of genomic lesions that affect the development of T cells. For many years, it has been established that deregulated expression of transcription factors, impairment of the CDKN2A/2B cell-cycle regulators, and hyperactive NOTCH1 ...
Girardi, Tiziana, Vicente, Carmen, Cools, Jan, De Keersmaecker, Kim   +3 more
openaire   +3 more sources

Infantile T-cell Acute Lymphoblastic Leukemia: a Case Report

Journal of Cancer and Allied Specialties, 2021
Introduction: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, with a male predominance. Pediatric acute lymphoblastic leukemia is usually of B-cell lineage; T-cell leukemia is uncommon and extremely rare under one year of ...
Natasha Baig, Sadia Muhammad, Sumaira Shaikh   +2 more
doaj   +1 more source

Changes in Expression of miR-1297 and PTEN Tumor Suppressor Gene in T-cell Acute Lymphoblastic Leukemia

Journal of Mazandaran University of Medical Sciences, 2021
Background and purpose: T-cell acute lymphoblastic leukemia (T-ALL) is a type of blood malignancy caused by changes in the precursors of T lymphocyte cells. The PTEN gene is one of the most common tumor suppressor genes that mutates in most human cancers,
Malihe Bagheri, Ghasem Mosayebi, Mahdieh Mondanizadeh   +2 more
doaj  

Specific lncRNA signatures discriminate childhood acute leukaemias: a pilot study

Cancer Cell International, 2022
Background Long non-coding RNAs are RNAs longer than 200 bps that do not encode any proteins and are able to alter gene expression by acting on different steps of regulation, including DNA methylation and chromatin structure.
Lorena Buono, Concetta Iside, Antonia De Matteo, Pio Stellato, Giuliana Beneduce, Roberta Penta de Vera d’Aragona, Rosanna Parasole, Marco Salvatore, Giovanni Smaldone, Peppino Mirabelli   +9 more
doaj   +1 more source

A Novel Risk Defining System for Pediatric T-Cell Acute Lymphoblastic Leukemia From CCCG-ALL-2015 Group

Frontiers in Oncology, 2022
ObjectiveT-cell acute lymphoblastic leukemia (T-ALL) is a rare hematological malignancy with a poor prognosis. The present study aims to identify the precise risk grouping of children with T-ALL.MethodsWe analyzed the outcomes for 105 consecutive ...
Xiaoming Liu, Yao Zou, Li Zhang, Ye Guo, Yumei Chen, Wenyu Yang, Xiaojuan Chen, Shuchun Wang, Yingchi Zhang, Min Ruan, Lixian Chang, Xiaoyan Zhang, Beibei Zhao, Ranran Zhang, Aoli Zhang, Lipeng Liu, Luyang Zhang, Meihui Yi, Xiaofan Zhu   +18 more
doaj   +1 more source

Mutational spectrum of adult T-ALL

Oncotarget, 2014
Novel target discovery is warranted to improve treatment in adult T-cell acute lymphoblastic leukemia (T-ALL) patients. We provide a comprehensive study on mutations to enhance the understanding of therapeutic targets and studied 81 adult T-ALL patients. NOTCH1 exhibitedthe highest mutation rate (53%).
Neumann, M., Vosberg, S., Schlee, C., Heesch, S., Schwartz, S., Gökbuget, N., Hoelzer, D., Graf, A., Krebs, S., Bartram, I., Blum, H., Brüggemann, M., Hecht, J., Bohlander, S.K., Greif, P.A., Baldus, C.D.   +15 more
openaire   +4 more sources

Muck & Magic Community Garden

, 2013
Sustainable organic vegetables, fruit and herb production for distribution to the participants of the community garden. All Age Groups, throughout the Ballymun community Global Action Plan Initiative Type Community Food Growing Projects Location ...
Healthy Food For All
core   +1 more source

Alteration in Expression of miR-32 and FBXW7 Tumor Suppressor in Plasma Samples of Patients with T-cell Acute Lymphoblastic Leukemia

Cancer Management and Research, 2020
Sanaz Mansouri,1,* Behzad Khansarinejad,2,* Ghasem Mosayebi,2 Aziz Eghbali,3 Mahdieh Mondanizadeh1,4 1Department of Biotechnology and Molecular Medicine, Arak University of Medical Sciences, Arak, Iran; 2Department of Microbiology and Immunology, Arak ...
Mansouri S, Khansarinejad B, Mosayebi G, Eghbali A, Mondanizadeh M   +4 more
doaj  

All-atom RMSD (Å) of chain pairs in apo and liganded T = 3 and T = 4 capsids¹.

, 2020
All-atom RMSD (Å) of chain pairs in apo and liganded T = 3 and T = 4 capsids1.
Weimin Wu (505435), Norman R. Watts (1964959), Rick Huang (8735664), Naiqian Cheng (8735661), Alasdair C. Steven (2468278), Paul T. Wingfield (189022)   +5 more
core   +1 more source