Results 51 to 60 of about 79,077 (284)

Identification of a porcine liver eomes-high-T-bet-low NK cell subset that resembles human liver resident NK cells [PDF]

, 2019
Natural killer (NK) cells are cells of the innate immunity and play an important role in the defense against viral infections and cancer, but also contribute to shaping adaptive immune responses. Long-lived tissue-resident NK cells have been described in
De Pelsmaeker, Steffi, Denaeghel, Sofie, Favoreel, Herman, Hermans, Leen   +3 more
core   +2 more sources

The Diagnostic Value of Transcription Factors T-bet/GATA3 Ratio in Predicting Antibody-Mediated Rejection [PDF]

Clinical and Developmental Immunology, 2013
Background. Previous data showed that the predominance of intraglomerular T-bet or GATA3 is correlated with different mechanisms of rejection, suggesting that the ratio of T-bet/GATA3 might be used to distinguish antibody-mediated rejection (ABMR) and T-cell-mediated rejection (TCMR).Methods.
Xue Li, Qiquan Sun, Mingchao Zhang, Jinsong Chen, Zhihong Liu   +4 more
openaire   +3 more sources

Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]

, 2015
CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele, Barnaba, Vincenzo, Calvo, Ludovica, Cavallari, EUGENIO NELSON, Citro, Alessandra, Coccia, Eliana M, D'Ettorre, Gabriella, DE MARZIO, Paolo, DI FILIPPO, Simona, Grazi, Gian Luca, Labbadia, Giancarlo, Martini, Helene, Martire, Carmela, Piconese, Silvia, Rizzo, Fabiana, Sette, Alessandro, Severa, Martina, Sidney, John, Vullo, Vincenzo   +18 more
core   +1 more source

Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2

Clinical and Developmental Immunology, 2012
T-bet plays an important role in immunoregulation; it induces the differentiation of Th1 together with the homeobox transcription factor gene Hlx.
Yan Xu, Jingjing Gao, Zhaoliang Su, Xiaoli Dai, Yazhen Li, Yingzhao Liu, Jianguo Chen, Jia Tong, Yun Zhang, Chaoyang Wu, Dong Zheng, Shengjun Wang, Huaxi Xu   +12 more
doaj   +1 more source

Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet [PDF]

Leukemia Research, 2005
A number of transcription factors (TFs) have been reported that play crucial roles in hematopoiesis. However, only little is known about how these factors are involved in the mechanisms of hematopoietic development and lineage commitment. To investigate the roles of TFs in human B-cell precursors (BCPs), the present study analyzed the expression of the
Akira, Harashima, Yoshinobu, Matsuo, Hans G, Drexler, Ayumi, Okochi, Ryuichi, Motoda, Mitsune, Tanimoto, Kunzo, Orita   +6 more
openaire   +2 more sources

HIV-specific CD8 + T cells exhibit reduced and differentially regulated Cytolytic activity in Lymphoid tissue [PDF]

, 2017
Elimination of lymphoid tissue reservoirs is a key component of HIV eradication strategies. CD8+ T cells play a critical role in control of HIV, but their functional attributes in lymph nodes (LNs) remain unclear.
Addo, Almeida, Altfeld, Andersson, Banga, Betts, Blackbourn, Bonecchi, Buggert, Chattopadhyay, Chun, Connick, Connick, Cruz-Guilloty, Cyster, Folkvord, Fukazawa, Gerdes, Goulder, He, Hersperger, Hersperger, Hersperger, Im, Jagannathan, Jenner, Jöhrens, Kern, Kiniry, Klatt, Koup, Leong, Lindqvist, Makedonas, Masopust, Matloubian, McKinnon, Migueles, Migueles, Migueles, Migueles, Munz, Mylvaganam, Oxenius, Pearce, Perreau, Petrovas, Petrovas, Pipkin, Pipkin, Price, Quigley, Quigley, Sallusto, Schmitz, Shacklett, Shekhar, Shiow, Sullivan, Szabo, Sáez-Cirión, Wills, Wolint, Wong, Yang   +64 more
core   +3 more sources

Transcription factor T-bet is a diagnostic marker for necrotizing enterocolitis development in premature newborns

Modern pediatrics. Ukraine, 2022
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease that mainly affects preterm infants. The non-specificity of the clinical picture and the high percentage of complications determine the need for early diagnosis and prevention of the disease.
O.E. Abaturov, A.O. Tovarnytska
openaire   +3 more sources

Nejire/dCBP-mediated control of H3 acetylation and transcriptional regulation by testis-specific Plus3 domain proteins during Drosophila spermatogenesis [PDF]

, 2018
Spermatogenesis describes the development from germ line stem cells to highly specialized sperm. Drosophila melanogaster spermatogenesis is a good model system for chromatin remodelling processes as many of these processes are similar in mammals and in ...
Hundertmark, Tim
core   +1 more source

The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells [PDF]

Immunity, 2012
Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-dependent colitis. Here, we show that interleukin-17A (IL-17A)-producing IL-7Rα(+) innate lymphoid cells (ILCs) were potent promoters of disease in Tbx21(-/-)Rag2(-/-) ulcerative colitis (TRUC) mice.
Powell, Nicholas, Walker, Alan W., Stolarczyk, Emilie, Canavan, James B., Goekmen, M. Refik, Marks, Ellen, Jackson, Ian, Hashim, Ahmed, Curtis, Michael A., Jenner, Richard G., Howard, Jane K., Parkhill, Julian, MacDonald, Thomas T., Lord, Graham M.   +13 more
openaire   +5 more sources

The Transcription Factor T-bet Regulates Mucosal T Cell Activation in Experimental Colitis and Crohn's Disease [PDF]

The Journal of Experimental Medicine, 2002
The balance between pro and antiinflammatory cytokines secreted by T cells regulates both the initiation and perpetuation of inflammatory bowel diseases (IBD). In particular, the balance between interferon (IFN)-γ/interleukin (IL)-4 and transforming growth factor (TGF)-β activity controls chronic intestinal inflammation. However, the molecular pathways
Neurath, M.F., Weigmann, B., Finotto, S., Glickman, J., Nieuwenhuis, E., Iijima, H., Mizoguchi, A., Mizoguchi, E., Mudter, J., Galle, P.R., Bhan, A., Autschbach, F., Sullivan, B.M., Szabo, S.J., Glimcher, L.H., Blumberg, R.S.   +15 more
openaire   +2 more sources