Results 61 to 70 of about 79,077 (284)

T-bet Expression in Peripheral Th17.0 Cells Is Associated With Pulmonary Function Changes in Sarcoidosis

Frontiers in Immunology, 2020
Background: Interferon-gamma (IFN-γ) is a key mediator of sarcoidosis-related granulomatous inflammation. Previous findings of IFN-γ-producing Th17 cells in bronchoalveolar lavage fluid from sarcoidosis patients invokes the transition of Th17.0 cells to ...
Nicholas K. Arger, Siddharth Machiraju, Isabel E. Allen, Prescott G. Woodruff, Laura L. Koth   +4 more
doaj   +1 more source

Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance [PDF]

Nature Immunology, 2014
Regulatory T cells (Treg cells) can express the transcription factors T-bet and GATA-3, but the function of this expression and whether such cells represent stable subsets is still unknown. By using various reporter tools, we found that the expression of T-bet and GATA-3 in Treg cells was dynamically influenced by the cytokine environment.
Fang, Yu, Suveena, Sharma, Julie, Edwards, Lionel, Feigenbaum, Jinfang, Zhu   +4 more
openaire   +2 more sources

Human Female Genital Tract Infection by the Obligate Intracellular Bacterium Chlamydia trachomatis Elicits Robust Type 2 Immunity [PDF]

, 2013
While Chlamydia trachomatis infections are frequently asymptomatic, mechanisms that regulate host response to this intracellular Gram-negative bacterium remain undefined.
AL Graham, AN Barclay, B Pulendran, BJ Wilson, C Cobaleda, C Soo, C Van Themsche, CR Cohen, Dean B. Matthews, FO Martinez, G Schaefer, G Tanaka, J Turner, JE Allen, JE Allen, JF Peipert, Jörn Coers, M Busslinger, M Molano, M Stein, M Wang, MJ Jardim, RC Brunham, RD Vicetti Miguel, RD Vicetti Miguel, RD Vicetti Miguel, RD Vicetti Miguel, RJ Snelgrove, RM Anthony, RM Hoek, Rodolfo D. Vicetti Miguel, S Fichtner-Feigl, S Fichtner-Feigl, S Fujisaka, Seth D. Reighard, Stephen A. K. Harvey, T Darville, Thomas L. Cherpes, V Hebbar, VH Hu, W Conca, William A. LaFramboise, WM Geisler   +42 more
core   +3 more sources

High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML

Cell Reports, 2016
Bromodomain and extra-terminal domain (BET) family inhibitors offer an approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across ...
Yue Zhao, Qi Liu, Pankaj Acharya, Kristy R. Stengel, Quanhu Sheng, Xiaofan Zhou, Hojoong Kwak, Melissa A. Fischer, James E. Bradner, Stephen A. Strickland, Sanjay R. Mohan, Michael R. Savona, Bryan J. Venters, Ming-Ming Zhou, John T. Lis, Scott W. Hiebert   +15 more
doaj   +1 more source

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation [PDF]

Nature Immunology, 2009
Several subsets of Foxp3(+) regulatory T cells (T(reg) cells) work in concert to maintain immune homeostasis. However, the molecular bases underlying the phenotypic and functional diversity of T(reg) cells remain obscure. We show that in response to interferon-gamma, Foxp3(+) T(reg) cells upregulated the T helper type 1 (T(H)1)-specifying transcription
Meghan A, Koch, Glady's, Tucker-Heard, Nikole R, Perdue, Justin R, Killebrew, Kevin B, Urdahl, Daniel J, Campbell   +5 more
openaire   +2 more sources

Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy [PDF]

, 2017
Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for cancer immunotherapy.
Mai, Antonello, Mazzone, Roberta, Valente, Sergio, Zwergel, Clemens   +3 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Aspergillus fumigatus preexposure worsens pathology and improves control of Mycobacterium abscessus pulmonary infection in mice [PDF]

, 2018
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Mutations in this chloride channel lead to mucus accumulation, subsequent recurrent pulmonary infections, and ...
Elsegeiny, Waleed, Gopal, Radha, Khader, Shabaana A, Kolls, Jay, McAleer, Jeremy P, Mehta, Shail, Monin, Leticia, Oury, Tim D   +7 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

EXPRESSION OF T-bet FACTOR IN PERIPHERAL BLOOD MONONUCLEAR CELLS IN BRONCHIAL ASTHMA

Медицинская иммунология, 2014
. We studied expression of transcription factor T-bet protein in allergic (ABA) versus non-allergic bronchial asthma (NABA), depending on severity grade and clinical phase of the disease.
V. N. Mineev, L. N. Sorokina
doaj   +1 more source