Results 1 to 10 of about 14,413,699 (306)

Increasing the odds: antibody-mediated delivery of two distinct immunogenic T-cell epitopes with one antibody [PDF]

OncoImmunology
Antibody-epitope conjugates (AECs) proved to be a promising new therapeutic strategy to redirect virus-specific CD8+ T cells toward cancer cells by delivering T-cell epitopes.
Willemijn van der Wulp, Dennis F. G. Remst, Carli S. Koster, Anne K. Wouters, Maaike E. Ressing, Janine Schuurman, Sander I. van Kasteren, Boris Bleijlevens, Rob C. Hoeben, Lars Guelen, Mirjam H. M. Heemskerk   +10 more
doaj   +2 more sources

A systematic review of T cell epitopes defined from the proteome of human immunodeficiency virus [PDF]

Virus Research
Background: Human immunodeficiency virus (HIV) persists as a formidable and far - reaching threat without a cure. T cells are crucial for antiviral immunity and pathology in HIV patients, with specific T cell epitopes potentially key to effective ...
Yan Ding, Ling Huang, Yandan Wu, Jialai Yan   +3 more
doaj   +2 more sources

Proteome-wide curation of experimentally validated HPV T-cell epitopes identifies key gaps in our understanding of cellular immunity to HPV and informs vaccine design [PDF]

Frontiers in Immunology
BackgroundHuman papillomavirus (HPV) drives both malignant and benign tumours. Current prophylactic vaccines are type-restricted, not optimised for T-cell induction, and lack therapeutic efficacy.
Syandrez Prima Putra, Syandrez Prima Putra, Syandrez Prima Putra, Selin Cankat, Leo Swadling   +4 more
doaj   +2 more sources

Predominant T-cell epitopes of SARS-CoV-2 restricted by multiple prevalent HLA-B and HLA-C allotypes in Northeast Asia [PDF]

Frontiers in Immunology
Since the outbreak of novel coronavirus pneumonia (COVID-19), numerous T-cell epitopes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteome have been reported.
Yu Zhao, Min Peng, Chengtao He, Min Li, Min Li, Xuelian Han, Xuelian Han, Qiang Fu, Yandan Wu, Fangping Yue, Chunguang Yan, Guangyu Zhao, Guangyu Zhao, Chuanlai Shen   +13 more
doaj   +2 more sources

Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients [PDF]

Frontiers in Immunology
IntroductionRecent surveillance has identified the emergence of the SARS-CoV-2 Omicron ariant, which exhibits the ability to evade multiple neutralizing antibodies generated by prior infection or vaccination.
Chanchan Xiao, Chanchan Xiao, Chanchan Xiao, Chanchan Xiao, Chanchan Xiao, Jian Xiang, Haoyun Wang, Wen Gao, Wen Gao, Tianchan Peng, Shumin Li, Shumin Li, Jun Su, Xi Chen, Lijuan Gao, Ruohu Shi, Xinyi Mou, Jun Yuan, Guobing Chen, Guobing Chen, Guobing Chen, Guobing Chen   +21 more
doaj   +2 more sources

A Systematic Review of T Cell Epitopes Defined from the Proteome of Hepatitis B Virus

Vaccines, 2022
Hepatitis B virus (HBV) infection remains a worldwide health problem and no eradicative therapy is currently available. Host T cell immune responses have crucial influences on the outcome of HBV infection, however the development of therapeutic vaccines,
Yandan Wu, Yan Ding, Chuanlai Shen
doaj   +1 more source

Idiotope-Driven T-Cell/B-Cell Collaboration-Based T-Cell Epitope Prediction Using B-Cell Receptor Repertoire Sequences in Infectious Diseases

Viruses, 2023
T-cell recognition of antigen epitopes is a crucial step for the induction of adaptive immune responses, and the identification of such T-cell epitopes is, therefore, important for understanding diverse immune responses and controlling T-cell immunity. A
Yukio Nakamura, Meng Ling Moi, Takashi Shiina, Tadasu Shin-I, Ryuji Suzuki   +4 more
doaj   +1 more source

Revelation of Potent Epitopes Present in Unannotated ORF Antigens of SARS-CoV-2 for Epitope-Based Polyvalent Vaccine Design Using Immunoinformatics Approach

Frontiers in Immunology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kills thousands of people worldwide every day, thus necessitating rapid development of countermeasures.
Patil Pranita Uttamrao, Chakkarai Sathyaseelan, L. Ponoop Prasad Patro, Thenmalarchelvi Rathinavelan   +3 more
doaj   +1 more source

BepiTBR: T-B reciprocity enhances B cell epitope prediction

iScience, 2022
Summary: The ability to predict B cell epitopes is critical for biomedical research and many clinical applications. Investigators have observed the phenomenon of T-B reciprocity, in which candidate B cell epitopes with nearby CD4+ T cell epitopes have ...
James Zhu, Anagha Gouru, Fangjiang Wu, Jay A. Berzofsky, Yang Xie, Tao Wang   +5 more
doaj   +1 more source

Direct identification of HLA class I and class II-restricted T cell epitopes in pancreatic cancer tissues by mass spectrometry

Journal of Hematology & Oncology, 2022
Background Identifying T cell epitopes on pancreatic ductal adenocarcinoma (PDAC) associated antigens or neoantigens has been a challenge. In this study, we attempted to identify PDAC T cell epitopes by mass spectrometry (MS).
Kenji Fujiwara, Yingkuan Shao, Nan Niu, Tengyi Zhang, Brian Herbst, Mackenzie Henderson, Stephen Muth, Pingbo Zhang, Lei Zheng   +8 more
doaj   +1 more source