Results 31 to 40 of about 14,413,699 (306)

In silico prediction of T- and B-cell epitopes in PmpD: First step towards to the design of a Chlamydia trachomatis vaccine

Biomedical Journal, 2018
Background: Chlamydia trachomatis is the most common sexually transmitted bacterial infection globally. Currently, there are no vaccines available despite the efforts made to develop a protective one.
Romina Cecilia Russi, Elian Bourdin, María Inés García, Carolina Melania I. Veaute   +3 more
doaj   +1 more source

Rapid and long-term disappearance of CD4+ T lymphocyte responses specific for Anaplasma marginale major surface protein-2 (MSP2) in MSP2 vaccinates following challenge with live A. marginale [PDF]

, 2005
In humans and ruminants infected with Anaplasma, the major surface protein 2 (MSP2) is immunodominant. Numerous CD4(+) T cell epitopes in the hypervariable and conserved regions of MSP2 contribute to this immunodominance.
Abbott, Jeffrey R, Howard, Chris J, Palmer, Guy H, Kegerreis, Kimberly A, Brown, Wendy C, Hope, Jayne; id_orcid, Hope, Jayne C, Hetrick, Peter F   +7 more
core   +1 more source

A Systematic, Unbiased Mapping of CD8+ and CD4+ T Cell Epitopes in Yellow Fever Vaccinees

Frontiers in Immunology, 2020
Examining CD8+ and CD4+ T cell responses after primary Yellow Fever vaccination in a cohort of 210 volunteers, we have identified and tetramer-validated 92 CD8+ and 50 CD4+ T cell epitopes, many inducing strong and prevalent (i.e., immunodominant) T cell
Anette Stryhn, Michael Kongsgaard, Michael Rasmussen, Mikkel Nors Harndahl, Thomas Østerbye, Maria Rosaria Bassi, Søren Thybo, Mette Gabriel, Morten Bagge Hansen, Morten Nielsen, Morten Nielsen, Jan Pravsgaard Christensen, Allan Randrup Thomsen, Soren Buus   +13 more
doaj   +1 more source

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
James P. Hindley, Ann Ager, van den Berg, Hugo A., McLaren, James Edward, Ladell, Kristin Ingrid, Marsden, Morgan, Hindley, James P., Godkin, Andrew, McLaren, James E., Price, D. A., James E. McLaren, Mathew Clement, Bridgeman, Hayley, Ian R. Humphreys, David A. Price, Hindley, James Philip, Gallimore, Awen Myfanwy, Humphreys, Ian R., Linda Wooldridge, Hugo A. van den Berg, Godkin, Andrew James, Clement, Mathew, Ager, Ann, Berg, Hugo van den, Hayley M. Bridgeman, Kristin Ladell, Andrew Godkin, Awen M. Gallimore, Morgan Marsden, Ladell, Kristin, Smart, Kathryn, Price, David, Kathryn Smart, Bridgeman, Hayley M., Wooldridge, Linda, Gallimore, Awen M.   +35 more
core   +1 more source

Identification of CD4+ T cell epitopes from Staphylococcus aureus secretome using immunoinformatic prediction and molecular docking [PDF]

, 2021
One major reason for the lack of clinical success of Staphylococcus aureus vaccine candidates is the inability of the antigens to develop a CD4+ T cell-mediated immune response. Hence, it is important to identify CD4+ T cell anti¬gens from S. aureus. CD4+
Arun Kumar, Dileep Francis, Francis, D., Sadasivan Chittalakkottu, Kumar, A., Chittalakkottu, S.   +5 more
core   +1 more source

Immunoinformatics Identification of the Conserved and Cross-Reactive T-Cell Epitopes of SARS-CoV-2 with Human Common Cold Coronaviruses, SARS-CoV, MERS-CoV and Live Attenuated Vaccines Presented by HLA Alleles of Indonesian Population

Viruses, 2022
Reports on T-cell cross-reactivity against SARS-CoV-2 epitopes in unexposed individuals have been linked with prior exposure to the human common cold coronaviruses (HCCCs). Several studies suggested that cross-reactive T-cells response to live attenuated
Marsia Gustiananda, Vivi Julietta, Angelika Hermawan, Gabriella Gita Febriana, Rio Hermantara, Lidya Kristiani, Elizabeth Sidhartha, Richard Sutejo, David Agustriawan, Sita Andarini, Arli Aditya Parikesit   +10 more
doaj   +1 more source

T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Frontiers in Immunology, 2021
CD4+ T-helper cells play an important role in alloimmune reactions following transplantation by stimulating humoral as well as cellular responses, which might lead to failure of the allograft.
Emma T. M. Peereboom, Benedict M. Matern, Toshihide Tomosugi, Toshihide Tomosugi, Matthias Niemann, Julia Drylewicz, Irma Joosten, Wil A. Allebes, Arnold van der Meer, Luuk B. Hilbrands, Marije C. Baas, Franka E. van Reekum, Marianne C. Verhaar, Elena G. Kamburova, Marc A. J. Seelen, Jan Stephan Sanders, Bouke G. Hepkema, Annechien J. Lambeck, Laura B. Bungener, Caroline Roozendaal, Marcel G. J. Tilanus, Christien E. Voorter, Lotte Wieten, Elly M. van Duijnhoven, Mariëlle A. C. J. Gelens, Maarten H. L. Christiaans, Frans J. van Ittersum, Azam Nurmohamed, Neubury M. Lardy, Wendy Swelsen, Karlijn A. van der Pant, Neelke C. van der Weerd, Ineke J. M. ten Berge, Fréderike J. Bemelman, Aiko P. J. de Vries, Johan W. de Fijter, Michiel G. H. Betjes, Michiel G. H. Betjes, Dave L. Roelen, Frans H. Claas, Henny G. Otten, Sebastiaan Heidt, Arjan D. van Zuilen, Takaaki Kobayashi, Kirsten Geneugelijk, Eric Spierings   +45 more
doaj   +1 more source

Novel, cross-restricted, conserved, and immunodominant Cytotoxic T Lymphocyte epitopes in slow progressors in HIV Type 1 infection [PDF]

, 1996
HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those ...
KARL McINTYRE, RODNEY E. PHILLIPS, Phillips, Rodney, Krausa, P, Phillips, R.E., Giangrande, P, SIOBHAN CROWLEY, Edwards, A., McIntyre, K., MIKE BUNCE, Morgan, B., Edwards, A, McMichael, A.J., Crowley, S, BARBARA MORGAN, ANNE EDWARDS, Morgan, B, Bunce, M, McMichael, Andrew, PETER KRAUSA, Crowley, S., Krausa, P., Goulder, P.J.R., Goulder, PJ, McIntyre, K, PAUL GIANGRANDE, ANDREW J. McMICHAEL, Giangrande, P., PHILIP J.R. GOULDER, McMichael, AJ, Bunce, M., Phillips, RE   +31 more
core   +1 more source

Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals

Scientific Reports, 2021
The COVID-19 pandemic has revealed a range of disease phenotypes in infected patients with asymptomatic, mild, or severe clinical outcomes, but the mechanisms that determine such variable outcomes remain unresolved.
Swapnil Mahajan, Vasumathi Kode, Keshav Bhojak, Coral Karunakaran, Kayla Lee, Malini Manoharan, Athulya Ramesh, Sudheendra HV, Ankita Srivastava, Rekha Sathian, Tahira Khan, Prasanna Kumar, Ravi Gupta, Papia Chakraborty, Amitabha Chaudhuri   +14 more
doaj   +1 more source

Tracking epitope-specific T cells [PDF]

Nature Protocols, 2009
The tracking of antigen-specific T cells in vivo is a useful approach for the study of the adaptive immune response. This protocol describes how populations of T cells specific for a given peptide-major histocompatibility complex (pMHC) epitope can be tracked based solely on T-cell receptor (TCR) specificity as opposed to other indirect methods based ...
James J, Moon, H Hamlet, Chu, Jason, Hataye, Antonio J, Pagán, Marion, Pepper, James B, McLachlan, Traci, Zell, Marc K, Jenkins   +7 more
openaire   +2 more sources