Results 51 to 60 of about 14,413,699 (306)

T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis. [PDF]

, 2015
There is an urgent need for a better understanding of adaptive immunity to Burkholderia pseudomallei, the causative agent of melioidosis that is frequently associated with sepsis or death in patients in Southeast Asia and Northern Australia.
Sumonwiriya, M, Makinde, Julia, Reynolds, Catherine, Altmann, D, Quigley, K, Rinchai, Darawan, Overbeek, S, Boyton, R, Yos, Pagnarith, Jenjaroen, Kemajittra, Maillere, Bernard, Manji, J, Yos, P, Reynolds, C, Musson, Julie, Overbeek, Saskia, Manji, Jiten, Spink, N, Bancroft, Gregory, Musson, J, Dunachie, S, Quigley, Kathryn, Bancroft, G, Goudet, Amélie, Wuthiekanun, Vanaporn, Wuthiekanun, V, Altmann, Daniel, Robinson, John, Lertmemongkolchai, Ganjana, Makinde, J, Rinchai, D, Robinson, J, Lertmemongkolchai, G, Holden, Matthew, Maillere, B, Dunachie, Susanna, Goudet, A, Holden, M, Jenjaroen, K, Spink, Natasha, Boyton, Rosemary, Sumonwiriya, Manutsanun   +41 more
core   +1 more source

Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin, Bérengère Koehl, Audrey Maudoux, Hanine Mansour, Marie‐Hélène Odievre, Nathalie Garrec, Emilie Georget, Cécile Arnaud, Slimane Allali, Lydia Doumdo, Marie Belloy, Corinne Guitton   +11 more
wiley   +1 more source

Landscape of epitopes targeted by T cells in 852 individuals recovered from COVID-19: Meta-analysis, immunoprevalence, and web platform

Cell Reports Medicine, 2021
Summary: Knowledge of the epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targeted by T cells in recovered (convalescent) individuals is important for understanding T cell immunity against coronavirus disease 2019 (COVID-19 ...
Ahmed Abdul Quadeer, Syed Faraz Ahmed, Matthew R. McKay   +2 more
doaj   +1 more source

CD4+ T cell epitopes of FliC conserved between strains of Burkholderia: implications for vaccines against melioidosis and cepacia complex in cystic fibrosis.

, 2014
Burkholderia pseudomallei is the causative agent of melioidosis characterized by pneumonia and fatal septicemia and prevalent in Southeast Asia. Related Burkholderia species are strong risk factors of mortality in cystic fibrosis (CF).
Nithichanon, Arnone, Lertmemongkolchai, Ganjana, Chu, Karen KY, Khaenam, Prasong, Rinchai, Darawan, Maillere, Bernard, Robinson, John H, Favry, Emmanuel, Bancroft, Gregory J, Reynolds, Catherine J, Altmann, Daniel M, Spink, Natasha, Boyton, Rosemary J, Musson, Julie A, De Soyza, Anthony   +14 more
core   +1 more source

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +3 more sources

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

In silico Guided Design of a Synthetic Peptide Vaccine Construct from Intrinsically Disordered Regions of the Group Specific Antigen Polyprotein

Biomedical and Biotechnology Research Journal
Background: The group specific antigen (Gag) polyprotein of human immunodeficiency virus-1 is an essential protein for the formation of virus particles and has emerged as a target for potential therapeutic interventions. Identification of viable linear B-
Gwyneth Anne A. Rabanal, Gaitano Arturo Lano III   +1 more
doaj   +1 more source

Removing celiac disease-related gluten proteins from bread wheat while retaining technological properties: a study with Chinese Spring deletion lines [PDF]

, 2009
Background Gluten proteins can induce celiac disease (CD) in genetically susceptible individuals. In CD patients gluten-derived peptides are presented to the immune system, which leads to a CD4+ T-cell mediated immune response and inflammation of the ...
Gilissen Ludovicus JWJ, Herpen, T.W.J.M., van, van der Meer, I.M., Dekking, L., Gilissen, L.J.W.J., Ludovicus JWJ Gilissen, Dirk Bosch, van den Broeck Hetty C, Cees Schuit, Liesbeth Dekking, Bosch, D., Smulders, M.J.M., Elma MJ Salentijn, van Herpen, T.W.J.M., Smulders Marinus JM, Dekking Liesbeth, van Herpen Teun WJM, Hamer Rob J, Rob J Hamer, Schuit Cees, Ingrid M van der Meer, Broeck, H.C., van den, Hamer, R.J., van der Meer Ingrid M, van den Broeck, H.C., Marinus JM Smulders, Bosch Dirk, Sub Membrane Biochemistry & Biophysics, Sub Membrane Enzymology begr. 01-06-12, Teun WJM van Herpen, Hetty C van den Broeck, Schuit, C., Salentijn, E.M.J., Salentijn Elma MJ, Membrane Enzymology   +34 more
core   +2 more sources

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response. [PDF]

PLoS ONE, 2012
Influenza virus infection and the resulting complications are a significant global public health problem. Improving humoral immunity to influenza is the target of current conventional influenza vaccines, however, these are generally not cross-protective.
James S Testa, Vivekananda Shetty, Julie Hafner, Zacharie Nickens, Shivali Kamal, Gomathinayagam Sinnathamby, Ramila Philip   +6 more
doaj   +1 more source