Epitope vaccine design for Toxoplasma gondii based on a genome-wide database of membrane proteins
Parasites & Vectors, 2022 Background There is presently no effective and safe vaccine for Toxoplasma gondii for humans. The study described here was designed to search for a novel group of optimal B cell and T cell epitopes from Toxoplasma membrane proteins using genome-wide ...
Xuan-Wu Li +9 more
doaj +1 more source
Human dendritic cells genetically engineered to express a melanoma polyepitope DNA vaccine induce multiple cytotoxic T-cell responses. [PDF]
, 2001 PURPOSE: To assess the therapeutic potential of a melanoma polyepitope vaccine in human cells. Polyepitope DNA vaccines encoding T-cell epitopes have been demonstrated in murine systems to generate multiple cytotoxic T-cell responses to different ...
Smith, SG +4 more
core +4 more sources
Vaccines, 2022 Recently, long synthetic peptides or in silico-predicted epitope peptides have been used to identify T cell epitopes, but these approaches may not be suitable for investigating naturally processed epitopes.
Hong-Seon Pyo +4 more
doaj +1 more source
Design of a Novel Multi-Epitope Vaccine Against Echinococcus granulosus in Immunoinformatics
Frontiers in Immunology, 2021 All the time, echinococcosis is a global zoonotic disease which seriously endangers public health all over the world. In order to speed up the development process of anti-Echinococcus granulosus vaccine, at the same time, it can also save economic cost ...
Mingkai Yu +9 more
doaj +1 more source
T-cell epitopes of the major peach allergen, Pru p 3: Identification and differential T-cell response of peach-allergic and non-allergic subjects [PDF]
, 2009 Lipid transfer proteins (LTPs), particularly peach Pru p 3, are the most relevant plant food allergens in the South of Europe, and, therefore, their allergic properties have been extensively studied.
Tordesillas Villuendas, Leticia +17 more
core +1 more source
Characterization of Conserved and Promiscuous Human Rhinovirus CD4 T Cell Epitopes [PDF]
, 2021 Human rhinovirus (RV) is the most common cause of upper respiratory infections and exacerbations of asthma. In this work, we selected 14 peptides (6 from RV A and 8 from RV C) encompassing potential CD4 T cell epitopes.
Reinherz, Ellis L. +15 more
core +1 more source
Anaplasma marginale major surface protein 2 CD4+-T-cell epitopes are evenly distributed in conserved and hypervariable regions (HVR), whereas linear B-cell epitopes are predominantly located in the HVR [PDF]
, 2004 Organisms in the genus Anaplasma express an immunodominant major surface protein 2 (MSP2), composed of a central hypervariable region (HVR) flanked by highly conserved regions.
Abbott, Jeffrey R +6 more
core +1 more source
Clinical & Translational Immunology, 2020 Objectives Bacillus Calmette–Guérin (BCG) vaccination has been implicated in protection against severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) and as a non‐specific immunisation method against the virus.
Szabolcs Urbán +4 more
doaj +1 more source
Does Antigen Glycosylation Impact the HIV-Specific T Cell Immunity?
Frontiers in Immunology, 2021 It is largely unknown how post-translational protein modifications, including glycosylation, impacts recognition of self and non-self T cell epitopes presented by HLA molecules.
Alex Olvera +11 more
doaj +1 more source
Advances in T-Cell Epitope Engineering [PDF]
Frontiers in Immunology, 2013 T-cells recognize small peptide fragments (p) cradled in multiple major histocompatibility complex (MHC) molecules, termed human leukocyte antigens (HLA) in humans. These membrane-integral pMHC molecules are present on surface of all nucleated cells and allow T-cells to detect aberrant intracellular activity, be this infection with microorganisms or ...
Johanne ePentier +4 more
openaire +7 more sources