Results 101 to 110 of about 4,863,715 (431)
Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor
Science, 2019 A boost for CAR–T cells Chimeric antigen receptor (CAR)–T cell immunotherapy has been highly successful for treating certain blood cancers. Yet this approach has been a challenge for solid tumors, in part because it is difficult to target functional ...
Leyuan Ma +17 more
semanticscholar +1 more source
Regulation of T Cell Apoptosis via T Cell Receptors and Steroid Receptors [PDF]
STEM CELLS, 1996 Less than 5% of immature CD4/CD8 double-positive (DP) thymocytes are positively selected to survive and differentiate into single-positive CD4 and CD8 T cells, while self-reactive DP thymocytes undergo apoptosis (negative selection). Both positive and negative selection events are active processes that involve signaling through the T cell receptors ...
Takeshi Kuwata +3 more
openaire +3 more sources
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, EarlyView.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
New simplified molecular design for functional T cell receptor [PDF]
, 1993 We have produced a chimeric single-chain T cell receptor (TcR) that combines the specific antibody recognition function and TcR/CD3 signaling properties within the same polypeptide chain.
Clevers +23 more
core +1 more source
Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance T-cell activation requires the translation of antigen binding to the T-cell receptor (TCR) into intracellular signaling. However, how antigen recognition and signal transduction are mechanistically linked is poorly understood.
Sophie V. Pageon +19 more
semanticscholar +1 more source
FEBS Letters, EarlyView.LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra +7 more
wiley +1 more source
Novel chimeric antigen receptor T cells based on T-cell receptor-like antibodies
Blood Science, 2019 . The need for novel therapeutics against human cancers such as leukemias and solid tumors is well recognized. Human T cells are poised to make a fundamental change in the therapeutic approach. T-cell interaction with a tumor cell is a critical event and
Qi Zhao
doaj +1 more source
Global Stability of McKeithan's Kinetic Proofreading Model for T-Cell Receptor Signal Transduction [PDF]
arXiv, 1999 This note presents a self-contained and streamlined exposition of chemical-network results due to Feinberg, Horn, and Jackson. As an application, it shows the global asymptotic stability to equilibria of McKeithan's kinetic proofreading model for T-cell receptor signal transduction.
arxiv
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. [PDF]
, 2016 Affinity and dose of T cell receptor (TCR) interaction with antigens govern the magnitude of CD4+ T cell responses, but questions remain regarding the quantitative translation of TCR engagement into downstream signals.
Allison, Karmel A +7 more
core +1 more source
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
Science, 2016 Outsourcing cancer immunotherapy Successful cancer immunotherapy depends on a patient's T cells recognizing tumor-specific mutations and then waging a lethal attack.
E. Strønen +10 more
semanticscholar +1 more source