Results 221 to 230 of about 4,863,715 (431)

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

Nature Network Boston, 2018
J. Fraietta, S. Lacey, Elena J Orlando, Iulian Pruteanu-Malinici, M. Gohil, Stefan Lundh, A. Boesteanu, Yan Wang, Roddy S. O’Connor, W. Hwang, E. Pequignot, David E. Ambrose, Changfeng Zhang, Nicholas Wilcox, F. Bedoya, C. Dorfmeier, Fang Chen, Lifeng Tian, Harit Parakandi, Minnal Gupta, R. Young, F. B. Johnson, I. Kulikovskaya, Li Liu, Jun Xu, Sadik H. Kassim, M. Davis, B. Levine, N. Frey, D. Siegel, Alexander C. Huang, E. Wherry, H. Bitter, J. Brogdon, D. Porter, C. June, J. Melenhorst   +36 more
semanticscholar   +1 more source

A Ki-1 (CD30)-positive human cell line (Karpas 299) established from a high-grade non-Hodgkin's lymphoma, showing a 2;5 translocation and rearrangement of the T-cell receptor beta-chain gene [PDF]

, 1988
Peter Fischer, Elisabeth P. Nacheva, DY Mason, PD Sherrington, Charles H.V. Hoyle, F. G. J. Hayhoe, Abraham Karpas   +6 more
openalex   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

The T-Cell Receptor [PDF]

Journal of Clinical Pathology, 1989
openaire   +2 more sources

Rearrangement and expression of T cell antigen receptor genes in B cell chronic lymphocytic leukemia [PDF]

, 1988
JD Norton, J Pattinson, A. V. Hoffbrand, H Jani, JC Yaxley, Brian Leber   +5 more
openalex   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

In vitro alteration of receptors for vasoactive intestinal peptide changes the in vivo localization of mouse T cells. [PDF]

, 1984
C. A. Ottaway
openalex   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

TCR-GPT: Integrating Autoregressive Model and Reinforcement Learning for T-Cell Receptor Repertoires Generation [PDF]

arXiv
T-cell receptors (TCRs) play a crucial role in the immune system by recognizing and binding to specific antigens presented by infected or cancerous cells. Understanding the sequence patterns of TCRs is essential for developing targeted immune therapies and designing effective vaccines.
arxiv