Results 251 to 260 of about 2,668,255 (357)

A Biologically Informed Vision-Guided Framework for Interpretable T Cell Receptor-Epitope Binding Prediction. [PDF]

Adv Sci (Weinh)
Yuan Y, Chen J, Zhang Y, Fang Y, Fang Z, Chu Y, Li J, Zhang C, Li Y, Wei D.   +9 more
europepmc   +1 more source

T-Cell Receptor Rearrangements Determined Using Fragment Analysis in Patients With T-Acute Lymphoblastic Leukemia

, 2018
Hyerim Kim, In‐Suk Kim, Chulhun L. Chang, Sun‐Young Kong, Young Tak Lim, Seom Gim Kong, Eun‐Hae Cho, Eun-Yup Lee, Ho‐Jin Shin, Hyeon Jin Park, Hyeon‐Seok Eom, Hye Won Lee   +11 more
openalex   +2 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

T cell receptor-engineered T cells targeting the TP53R248Q neoantigen elicit antitumor effects in human cancer models. [PDF]

J Clin Invest
Shen L, Chen Z, Xu J, He Q, Zhang C, Zhou X, Ding X, Fang J, Li F, Jiao M, Yang Y, Dong B, Wan L, Ding X, Zheng Y, Zhou J, Zuo C, Min T, Zhu M, Ma B, Wan Y, Guo Q, Zhang H, Hua J, Wang P, Li Q, Long J, Song X, Zhang Y.   +28 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

T-cell receptor gamma (TRG) diversity predicts peripheral blood involvement in primary cutaneous T-cell lymphoma. [PDF]

Blood Neoplasia
Ramesh R, Colbourn R, Van Deerlin VM, Halper-Stromberg E.   +3 more
europepmc   +1 more source

A ‘sweet spot’ for complement receptor CD46 activity: CYT-1 regulates glycolytic and moonlighting functions of glycolytic enzymes during human CD4+ T cell activation

Natalia Kunz, Gaëlle Le Friec, Jack Bibby, Erin E. West, Ayden Case, Parul Singh, Nicolas S. Merle, Paul Lavender, Majid Kazemian, Christoph Hess, Claudia Kemper   +10 more
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

T cell receptor clonotypes predict human leukocyte antigen allele carriage and antigen exposure history. [PDF]

Commun Biol
ElAbd H, Mahdy AKH, Wacker EM, Gretsova M, Ellinghaus D, Dempfile A, Franke A.   +6 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source