Results 21 to 30 of about 4,863,715 (431)

G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment. [PDF]

, 2018
The requirements for effector and memory CD8 T cell development are incompletely understood. Recent work has revealed a role for G-protein coupled receptor 18 (GPR18) in establishment of the intestinal CD8αα intraepithelial lymphocyte compartment.
Cyster, Jason G, Sumida, Hayakazu
core   +2 more sources

HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread [PDF]

, 2016
open access articleHIV-1 spreads between CD4 T cells most efficiently through virus-induced cell-cell contacts. To test whether this process potentiates viral spread by activating signaling pathways, we developed an approach to analyze the ...
Jolly, Clare, Len, Alice C.L., Shivkumar, Maitreyi, Starling, Shimona   +3 more
core   +2 more sources

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

Nature Communications, 2020
T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is shown ...
Irini Evnouchidou, Pascal Chappert, Samira Benadda, Andres Zucchetti, Mirjana Weimershaus, Marcelle Bens, Vivien Caillens, Despoina Koumantou, Sophie Lotersztajn, Peter van Endert, Jean Davoust, Pierre Guermonprez, Claire Hivroz, David A. Gross, Loredana Saveanu   +14 more
doaj   +1 more source

Axicabtagene Ciloleucel CAR T‐Cell Therapy in Refractory Large B‐Cell Lymphoma

New England Journal of Medicine, 2017
Background In a phase 1 trial, axicabtagene ciloleucel (axi‐cel), an autologous anti‐CD19 chimeric antigen receptor (CAR) T‐cell therapy, showed efficacy in patients with refractory large B‐cell lymphoma after the failure of conventional therapy. Methods
S. Neelapu, F. Locke, N. Bartlett, L. Lekakis, D. Miklos, C. Jacobson, I. Braunschweig, O. Oluwole, T. Siddiqi, Yi Lin, J. Timmerman, P. Stiff, J. Friedberg, I. Flinn, A. Goy, B. Hill, Mitchell R. Smith, A. Deol, U. Farooq, P. Mcsweeney, J. Muñoz, I. Avivi, J. Castro, J. Westin, J. Chavez, A. Ghobadi, K. Komanduri, R. Levy, E. Jacobsen, T. Witzig, P. Reagan, A. Bot, J. Rossi, L. Navale, Yi-zhou Jiang, J. Aycock, M. Elias, David D. Chang, J. Wiezorek, W. Go   +39 more
semanticscholar   +1 more source

Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene. [PDF]

, 1996
A variant of severe combined immunodeficiency syndrome (SCID) with a selective inability to produce CD8 single positive T cells and a signal transduction defect in peripheral CD4+ cells has recently been shown to be the result of mutations in the ZAP-70 ...
Bacon, KB, Gelfand, EW, Jahn, T, Kadlecek, TA, Kohn, DB, Smith, S, Taylor, N, Uribe, L, Weinberg, K, Weiss, A   +9 more
core   +1 more source

Phase separation of signaling molecules promotes T cell receptor signal transduction

Science, 2016
Phase separation organizes signaling In T cell receptors, signaling molecules reorganize into tiny phase-separated droplets—like oil in water. Su et al. used an in vitro system with artificial membranes and 12 components of the T cell receptor signaling ...
Xiaolei Su, Jonathon A. Ditlev, E. Hui, Wenmin Xing, Sudeep Banjade, Julia Okrut, D. King, J. Taunton, M. Rosen, R. Vale   +9 more
semanticscholar   +1 more source

Fluoxetine suppresses calcium signaling in human T lymphocytes through depletion of intracellular calcium stores [PDF]

, 2015
Selective serotonin reuptake inhibitors, such as fluoxetine, have recently been shown to exert anti-inflammatory and immunosuppressive effects. Although the effects on cytokine secretion, proliferation and viability of T lymphocytes have been extensively
Broeckx, Bart, De Bock, Marijke, De Spiegelaere, Ward, Deforce, Dieter, Gobin, Veerle, Kiselinova, Maja, Leybaert, Luc, Van Steendam, Katleen, Vandekerckhove, Linos   +8 more
core   +2 more sources

T cell receptor signaling for γδT cell development

Inflammation and Regeneration, 2019
T cells are central to the vertebrate immune system. Two distinct types of T cells, αβT and γδT cells, express different types of T cell antigen receptors (TCRs), αβTCR and γδTCR, respectively, that are composed of different sets of somatically ...
Ryunosuke Muro, Hiroshi Takayanagi, Takeshi Nitta   +2 more
doaj   +1 more source

altered expression of cD300a inhibitory receptor on cD4+ T cells From human immunodeficiency Virus-1-infected Patients: association With Disease Progression Markers. [PDF]

, 2018
The ability of the CD300a inhibitory receptor to modulate immune cell functions and its involvement in the pathogenesis of many diseases has aroused a great interest in this molecule.
Genebat González, Miguel, Leal Noval, Manuel, Ruiz-Mateos Carmona, Ezequiel, Tarancon Diez, Laura   +3 more
core   +1 more source

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy.

New England Journal of Medicine, 2016
A patient with recurrent multifocal glioblastoma received chimeric antigen receptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 (IL13Rα2).
Christine E. Brown, D. Alizadeh, R. Starr, L. Weng, J. Wagner, A. Naranjo, J. Ostberg, M. S. Blanchard, Julie Kilpatrick, Jennifer Simpson, Anita Kurien, J. Saul, Priceman, Xiuli Wang, T. Harshbarger, M. D’Apuzzo, J. Ressler, M. Jensen, M. Barish, M. Chen, J. Portnow, S. Forman, B. Badie   +22 more
semanticscholar   +1 more source