The LCMV gp33-specific memory T cell repertoire narrows with age
Immunity & Ageing, 2012 Background The memory response to LCMV in mice persists for months to years with only a small decrease in the number of epitope specific CD8 T cells. This long persistence is associated with resistance to lethal LCMV disease.
Bunztman Adam +4 more
doaj +1 more source
TCR-T immunotherapy for the treatment of solid tumor: current status, challenges and future prospects [PDF]
Zhongguo aizheng zazhi, 2023 Engineered T cell receptor-T cell (TCR-T) therapy and chimeric antigen receptor-T cell (CAR-T) therapy are currently the two most effective ways of adoptive T cell therapy.
ZHENG Weitao, LI Hanluo, HU Kanghong
doaj +1 more source
CD155 on HIV-infected cells is not modulated by HIV-1 Vpu and Nef but synergizes with NKG2D ligands to trigger NK cell lysis of autologous primary HIV-infected cells [PDF]
, 2017 Activation of primary CD4(+) T cells induces the CD155, but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)].
Barker, Edward +5 more
core +2 more sources
Quantifying selection in immune receptor repertoires [PDF]
Proc Natl Acad Sci USA 111(27) 9875-9880 (2014), 2014 The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an initial random DNA editing process, called VDJ recombination, followed by functional selection of cells according to the interaction of their surface receptors with
arxiv +1 more source
Journal of Experimental Medicine, 2002 To identify endocytic receptors that allow dendritic cells (DCs) to capture and present antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated DEC-205, which is abundant on DCs in lymphoid tissues.
L. Bonifaz +5 more
semanticscholar +1 more source
Discovery of the first PD-1 ligand encoded by a pathogen
Frontiers in Immunology, 2022 Large double-stranded DNA viruses deploy multiple strategies to subvert host immune defenses. Some of these tactics are mediated by viral gene products acquired by horizontal gene transfer from the corresponding hosts and shaped throughout evolution. The
Pablo Martínez-Vicente +8 more
doaj +1 more source
Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones [PDF]
eLife 2020;9:e53704 (2020), 2019 The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune response to infections. Previous studies show that secondary responses to the yellow fever vaccine - the model for acute infection in humans - are weaker than primary ones, but only quantitative measurements can describe the concentration changes and lineage fates ...
arxiv +1 more source
Characterization of avian natural killer cells and their intracellular CD3 protein complex [PDF]
, 1994 Natural killer (NK) cell activity appears to be conserved throughout vertebrate development but NK cells have only been well characterized in mammals. Candidate NK cells have been identified in the chicken as cytoplasmic CD3+ and surface T cell receptor (
Anderson +48 more
core +1 more source
A Novel Approach for the Treatment of T Cell Malignancies: Targeting T Cell Receptor Vβ Families
Vaccines, 2020 Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. The lack of targeted immunotherapeutic approaches for T cell malignancies results in part from potential risks associated with targeting broadly expressed
Jie Wang +7 more
doaj +1 more source
Broad cross-reactivity of the T-cell repertoire achieves specific and sufficiently rapid target searching [PDF]
, 2017 The molecular recognition of T-cell receptors is the hallmark of the adaptive immunity. Given the finiteness of the T-cell repertoire, individual T-cell receptors are necessary to be cross-reactive to multiple antigenic peptides. In this study, we quantify the variability of the cross-reactivity by using a string model that estimates the binding ...
arxiv +1 more source