Results 11 to 20 of about 564,677 (319)
Cytotoxic Responses Mediated by NK Cells and Cytotoxic T Lymphocytes in Xenotransplantation [PDF]
Transplant InternationalXenotransplantation represents a potential solution to the shortage of organs for transplantation. The recent advancements in porcine genetic modification have addressed hyperacute and acute vascular rejection; however, challenges persist with regard to ...
Viktoriia Galdina +2 more
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IL-27: overclocking cytotoxic T lymphocytes to boost cancer immunotherapy [PDF]
Signal Transduction and Targeted TherapySilvia Dusi +2 more
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Resistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes. [PDF]
Proceedings of the National Academy of Sciences, 1987 To investigate how cytotoxic T lymphocytes (CTL) avoid killing themselves when they destroy target cells, we compared 20 different cell lines as target cells, including several CTL cell lines, for their susceptibility to lysis by CTL. Variations in recognition of this diverse set of target cells was circumvented by attaching to all of them a monoclonal
David M. Kranz, Herman N. Eisen
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Cytotoxic T lymphocytes could contribute in COVID-19-induced passing anosmia
Studia Medyczne, 2021 Several clinical reports have demonstrated a spectrum of neurological manifestations of COVID-19 patients with subsequent post-mortem neuropathological findings. The aim of the case description is to show spotty inflammatory lesions in the olfactory bulb,
Marcin Zaremba +2 more
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Optimal control of an HIV model with a trilinear antibody growth function [PDF]
Discrete Contin. Dyn. Syst. Ser. S 15 (2022), no. 3, 501--518, 2021 We propose and study a new mathematical model of the human immunodeficiency virus (HIV). The main novelty is to consider that the antibody growth depends not only on the virus and on the antibodies concentration but also on the uninfected cells concentration.
arxiv +1 more source
High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity [PDF]
Frontiers in Immunology, 2021 Cytotoxic T lymphocytes (CTLs) are key players to eliminate tumorigenic or pathogen-infected cells using lytic granules (LG) and Fas ligand (FasL) pathways. Depletion of glucose leads to severely impaired cytotoxic function of CTLs. However, the impact of excessive glucose on CTL functions still remains largely unknown.
Jie Zhu +19 more
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Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes
Frontiers in Immunology, 2020 Granules of cytotoxic T lymphocytes (CTL) are derived from the lysosomal compartment. Synaptotagmin7 (Syt7) appears to be the calcium sensor triggering fusion of lysosomes in fibroblasts. Syt7 has been proposed to control cytotoxic granule (CG) fusion in
Marwa Sleiman +3 more
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Медицинская иммунология, 2020 We studied sex differences lymphocytes subpopulations of peripheral blood in adult C57Bl/6 mice during acute and chronic colitis, induced with 1% DSS. We measured subpopulations of lymphocytes with flow cytometry.
O. V. Makarova +3 more
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Healthy aging—would cytotoxic T lymphocytes stand out?
Cell Death Discovery, 2023 Senescent cells (SnCs) accumulate in multiple tissue types with the process of individual aging, hindering tissue renewal and driving multiple aging-related disorders.
Tianyu Zhang, Jinjin Zhang, Shixuan Wang
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Cytotoxicity of lymphocytes in the newborn. [PDF]
Archives of Disease in Childhood, 1981 Antibody-dependent, phytohaemagglutinin-induced, and spontaneous cytotoxicity was studied in 44 term and 60 preterm newborn babies, all of whom were healthy and of normal weight for gestational age. Twenty-seven adults were used as controls. Antibody-dependent cytotoxicity was low in term babies particularly in the preterm ones during the first 4 days ...
N Matsaniotis +3 more
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