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Cytotoxic T Lymphocytes in Resistance to Tuberculosis
1998Recent experimental evidence has suggested T cells recognizing antigens in the context of both classical MHC class I and nonclassical class I-like molecules contribute to protective responses against Mycobacterium tuberculosis (MTB) infection. Our aims were to characterize both types of T cells, and to explore the basis of communication between the ...
R J, Mazzaccaro +6 more
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CD4 cytotoxic T lymphocyte differentiation
Biochimie, 1988In vitro allostimulated CD4+ human lymphocytes were cloned by micromanipulation and expanded for a short time in IL-2 conditioned medium. In the present study we observed that proliferative noncytotoxic cloned cells were able to acquire the specific cytolytic activity under some modification of the cloned cells restimulation cycle. We demonstrated that
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Radiosensitivity of Murine T-Lymphocyte Cytotoxicity
Radiation Research, 1984A biphasic curve was observed when surviving allogeneic lytic activity was plotted as a function of irradiation delivered before sensitization. Flow cytometry analysis demonstrated that the number of cells was reduced in response to increasing dose and that subset precursors Lyt 1+2+ were proportionally more radiosensitive than the other subsets ...
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Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones
Immunity, 2022Pablo Tebas +2 more
exaly
Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen
Cell, 2023Marjan Azin +2 more
exaly
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19
Cell, 2020Alessandro Sette +2 more
exaly